vitamin A deficiency

Summary

vitamin A deficiency (MONDO:0007016) is a disease and 55 clinical trials. Top therapeutic interventions include retinol, beta carotene, and vitamin a palmitate. A subtype of vitamin deficiency disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 55

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	vitamin A deficiency
Mondo ID	MONDO:0007016
EFO	EFO:1001237
MeSH	D014802
ICD-10-CM	E50
ICD-11	435342452
NCIT	C85220
SNOMED CT	72000004
UMLS	C0042842
MedGen	22668
MedDRA	10047586
Is cancer (heuristic)	no

Also known as: deficiencies, vitamin A · deficiency, vitamin A · vitamin A deficiencies · vitamin A deficiency · vitamin A deficiency (disease)

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of vitamin deficiency disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › nutritional disorder › nutritional deficiency disease › vitamin deficiency disorder › vitamin A deficiency

Related subtypes (7): nutritional biotin deficiency, vitamin K deficiency hemorrhagic disease, inborn vitamin metabolic disorder, scurvy, vitamin B deficiency, vitamin D deficiency, vitamin deficiency related neuropathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Retinol	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 55.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	39
PHASE3	6
PHASE2	6
PHASE2/PHASE3	2
EARLY_PHASE1	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00128557	PHASE3	COMPLETED	Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh
NCT00198822	PHASE3	COMPLETED	Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh
NCT00211341	PHASE3	COMPLETED	Trial of the Impact of Vitamin A on Maternal Mortality
NCT00742937	PHASE2/PHASE3	COMPLETED	Impact of Maternal Supplementation With Dual Megadose of Vitamin A
NCT01695148	PHASE3	COMPLETED	Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children
NCT02043223	PHASE2/PHASE3	COMPLETED	Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit
NCT02804490	PHASE3	COMPLETED	Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status
NCT03876704	PHASE3	UNKNOWN	Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants
NCT06450925	PHASE2	RECRUITING	Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.
NCT00053612	PHASE2	COMPLETED	Vitamin A to Reduce HIV in Vaginal Secretions and Prevent Viral Transmission
NCT00198718	PHASE2	COMPLETED	Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates
NCT00680212	PHASE2	COMPLETED	Vitamin A Equivalence of Plant Carotenoids in Children
NCT01381276	PHASE2	COMPLETED	Vitamin A Absorption From Cassava in Women
NCT01476358	PHASE2	UNKNOWN	Effect of Vitamin A Supplementation on Immune Responses in Human Neonates
NCT01061307	EARLY_PHASE1	COMPLETED	An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand
NCT01199445	EARLY_PHASE1	COMPLETED	Efficacy of Vitamin A in Fortified Extruded Rice in School Children
NCT04694235	Not specified	ACTIVE_NOT_RECRUITING	Egg Intervention During Pregnancy in Indonesia
NCT05323292	Not specified	ENROLLING_BY_INVITATION	Vitamin A Status in Patients With Vocal Fold Leukoplakia
NCT06759493	Not specified	RECRUITING	Validation and Simplification of the Retinol Isotope Dilution Technique in Burkinabe Schoolchildren
NCT07335991	Not specified	RECRUITING	Effect of Vitamin A Supplementation on Idiopathic Scoliosis
NCT00082420	Not specified	COMPLETED	Retinol Equivalence of Plant Carotenoids in Children
NCT00453648	Not specified	COMPLETED	Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age
NCT00674089	Not specified	COMPLETED	Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan
NCT01420406	Not specified	COMPLETED	Vitamin A Bioavailability in Lactating Women With Marginal Vitamin A Status
NCT01559766	Not specified	COMPLETED	Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment
NCT01583972	Not specified	COMPLETED	Efficacy of Newborn Vitamin A Supplementation in Improving Immune Function
NCT01614483	Not specified	COMPLETED	Efficacy of Yellow Cassava to Improve Vitamin A Status of Kenyan School Children
NCT01922713	Not specified	COMPLETED	Effect of Daily Consumption of Orange Maize on Breast Milk Retinol in Lactating Zambian Women
NCT02027610	Not specified	COMPLETED	Vitamin A, Stool Microbiota and Vaccine Response in Bangladeshi Infants
NCT02210507	Not specified	COMPLETED	Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari
NCT02276014	Not specified	COMPLETED	Effect of SNPs in the BCMO1 Enzyme
NCT02363985	Not specified	COMPLETED	Using Stable Isotope Techniques to Monitor and Assess the Vitamin A Status of Children Susceptible to Infection
NCT02627222	Not specified	COMPLETED	The Efficacy of Pro-vitamin A Biofortified Cassava on Vitamin A Status in Nigerian Preschool Children
NCT02648893	Not specified	UNKNOWN	Effect Of Multiple Biofortified Food Crops On Micronutrient Status And Immune Function Among Indian Infants and Their Mothers
NCT02702622	Not specified	COMPLETED	Vitamin A Equivalence of the Provitamin A in Biofortified Bananas
NCT02760095	Not specified	COMPLETED	Effects of EED on Zn Absorption and Retention in Children From a Standard Dose
NCT02847962	Not specified	COMPLETED	Newly Formulated, Extruded Fortified-blended Foods for Food Aid: the MFFAPP Tanzania Efficacy Study
NCT02996513	Not specified	COMPLETED	Assessing Model Parameters for Applying the Retinol Isotope Dilution (RID) Method
NCT03305042	Not specified	COMPLETED	Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death
NCT03353662	Not specified	UNKNOWN	Sub Regional Micronutrient Survey in Ethiopia

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
RETINOL	4	9
BETA CAROTENE	4	1
VITAMIN A PALMITATE	4	1
CHEMBL3774468	0	1
CHEMBL4787961	0	1
CHEMBL1201279	0	1