Vulvar disease
disease diseaseOn this page
Also known as disorder of vulvavulvar disorder
Summary
Vulvar disease (MONDO:0002187) is a disease and 15 clinical trials. Top therapeutic interventions include hydroxyzine, loperamide, and prochlorperazine. A subtype of female reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 15
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | vulvar disease |
| Mondo ID | MONDO:0002187 |
| MeSH | D014845 |
| DOID | DOID:2059 |
| NCIT | C27631 |
| SNOMED CT | 5089007 |
| UMLS | C0042994 |
| MedGen | 53055 |
| Is cancer (heuristic) | no |
Also known as: disorder of vulva · vulvar disease · vulvar disorder
Disease family
This is a subtype of female reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › vulvar disease
Related subtypes (33): ectopic pregnancy, pelvic inflammatory disease, endosalpingiosis, vaginal disorder, prolapse of female genital organ, Allen-Masters syndrome, fallopian tube disorder, uterine disorder, gynatresia, Bartholin duct cyst, ovarian disorder, hymen, imperforate, preterm premature rupture of the membranes, mammary-digital-nail syndrome, Asherman syndrome, uterine cervical aplasia and agenesis, longitudinal vaginal septum, transverse vaginal septum, polycystic ovaries-urethral sphincter dysfunction syndrome, granulomatous mastitis, vaginal atresia, mullerian aplasia, vulvovaginal gingival syndrome, isolated partial vaginal agenesis, female infertility, female reproductive system neoplasm, polyp of vulva, vulval varices, vulvodynia, menstrual cycle-dependent periodic fever, Bartholin’s gland disease, delayed puberty, self-limited, menstrual disorder
Subtypes (4): ulceration of vulva, vulvar dystrophy, vulvitis, vulvar neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 15.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 8 |
| PHASE1/PHASE2 | 3 |
| PHASE4 | 1 |
| PHASE3 | 1 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00119886 | PHASE4 | UNKNOWN | Botox on Vulvar Vestibulitis |
| NCT00496184 | PHASE3 | COMPLETED | Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis |
| NCT05592626 | PHASE1/PHASE2 | RECRUITING | A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors |
| NCT06075264 | PHASE2 | RECRUITING | Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3) |
| NCT00004316 | PHASE1/PHASE2 | COMPLETED | Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis |
| NCT02858310 | PHASE1/PHASE2 | COMPLETED | E7 TCR T Cells for Human Papillomavirus-Associated Cancers |
| NCT03792516 | PHASE1 | COMPLETED | Artesunate Ointment for the Treatment of High Grade Vulvar Intraepithelial Neoplasia (HSIL VIN2/3) |
| NCT05890092 | Not specified | RECRUITING | Vulvar Disease in Nigeria Observational Study |
| NCT06070454 | Not specified | RECRUITING | Prospective Evaluation of Infectious Vulvovaginitis on Wound Complication Rates After Vulvar Excision for Premalignant Lesions |
| NCT06495554 | Not specified | RECRUITING | Danish Vulva Cancer Recurrence Study |
| NCT07607470 | Not specified | NOT_YET_RECRUITING | Large Algorithm Setting and Validation Study |
| NCT00276068 | Not specified | COMPLETED | Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine |
| NCT02881229 | Not specified | TERMINATED | Vulvar Mucosal Specialty Clinic Chart Review |
| NCT03444727 | Not specified | TERMINATED | Treatment Prior to Injection and Biopsy of the Vulva |
| NCT05478746 | Not specified | COMPLETED | Effects of Flourish HEC on Localized Provoked Vulvodynia |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| HYDROXYZINE | 4 | 3 |
| LOPERAMIDE | 4 | 3 |
| PROCHLORPERAZINE | 4 | 3 |
| ARTESUNATE | 4 | 1 |
| ATROPINE SULFATE | 4 | 1 |
| CAPSAICIN | 4 | 1 |
| CODEINE SULFATE | 4 | 1 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 4 | 1 |
| DIPHENOXYLATE HYDROCHLORIDE | 4 | 1 |
| DROPERIDOL | 4 | 1 |
| GRANISETRON | 4 | 1 |
| INDOMETHACIN | 4 | 1 |
| MEPERIDINE | 4 | 1 |
| ONABOTULINUMTOXINA | 4 | 1 |
| ZUCAPSAICIN | 3 | 1 |
| CHEMBL284671 | 0 | 1 |
| CHEMBL399538 | 0 | 1 |
| YEAST, DRIED | -1 | 1 |