Vulvar intraepithelial neoplasia
diseaseOn this page
Also known as intraepithelial neoplasia of the vulvaintraepithelial neoplasia of vulvasquamous vulvar intraepithelial neoplasiaVINvulva intraepithelial neoplasiavulval intraepithelial neoplasiavulvar intraepithelial tumorvulvar intraepithelial tumour
Summary
Vulvar intraepithelial neoplasia (MONDO:0005198) is a disease and 20 clinical trials. Top therapeutic interventions include imiquimod, human papillomavirus, l1 protein virus like particles, and methyl aminolevulinate hydrochloride. A subtype of vulvar squamous neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-5 / 10 000 (Europe) [Orphanet-validated]
- Clinical trials: 20
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 20 | Europe | Validated |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | vulvar intraepithelial neoplasia |
| Mondo ID | MONDO:0005198 |
| EFO | EFO:0002627 |
| Orphanet | 137583 |
| NCIT | C4756 |
| UMLS | C0346210 |
| MedGen | 91093 |
| GARD | 0019876 |
| Is cancer (heuristic) | no |
Also known as: intraepithelial neoplasia of the vulva · intraepithelial neoplasia of vulva · squamous vulvar intraepithelial neoplasia · VIN · vulva intraepithelial neoplasia · vulval intraepithelial neoplasia · vulvar intraepithelial tumor · vulvar intraepithelial tumour
Data availability: 1 cell line.
Disease family
An umbrella term covering 1 Mondo subtype.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › squamous cell neoplasm › vulvar squamous neoplasm › vulvar intraepithelial neoplasia
Related subtypes (3): vestibular papilloma, vulvar seborrheic keratosis, vulvar squamous cell carcinoma
Subtypes (1): low grade vulvar intraepithelial neoplasia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Imiquimod | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Omiganan.
Clinical trials & evidence
Clinical trials
Clinical trials: 20.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 10 |
| PHASE3 | 4 |
| PHASE2 | 3 |
| PHASE4 | 1 |
| EARLY_PHASE1 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05426148 | PHASE4 | COMPLETED | Lot Consistency Clinical Trial of of Recombinant HPV Bivalent Vaccine in 9 to14 Years Old Healthy Female |
| NCT01735006 | PHASE3 | COMPLETED | Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent（Type 16/18 ）Vaccine |
| NCT01861535 | PHASE3 | COMPLETED | Primary Imiquimod Treatment Versus Surgery for Vulvar Intraepithelial Neoplasia |
| NCT02562508 | PHASE3 | COMPLETED | A Bridging Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls |
| NCT05580341 | PHASE3 | UNKNOWN | Phase III Study Comparing the Immunogenicity of 9-valent HPV Recombinant Vaccine and Gardasil-9 |
| NCT01986725 | PHASE2 | COMPLETED | The Impact of the WOMAN-PRO II Program on Patients With Vulvar Neoplasia to Minimize Post-surgical Symptom Prevalence |
| NCT03180684 | PHASE2 | COMPLETED | Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and/or HPV-18 Related Vulvar HSIL (Also Referred as: VIN 2 or VIN 3) |
| NCT05104099 | PHASE2 | COMPLETED | Evaluation of New Diagnostic Tool Using Fluorescence to Detect High-grade Vulvar Intraepithelial Neoplasia |
| NCT03792516 | PHASE1 | COMPLETED | Artesunate Ointment for the Treatment of High Grade Vulvar Intraepithelial Neoplasia (HSIL VIN2/3) |
| NCT01676792 | EARLY_PHASE1 | COMPLETED | SR-T100 Gel Efficacy & Safety Study for Vulva Pre-cancerous Lesions & Cutaneous Condyloma |
| NCT05463796 | Not specified | RECRUITING | InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer |
| NCT02140021 | Not specified | TERMINATED | Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer |
| NCT02735109 | Not specified | TERMINATED | Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors |
| NCT02875561 | Not specified | COMPLETED | Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia |
| NCT03206255 | Not specified | COMPLETED | Immuno-persistence Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls |
| NCT04704908 | Not specified | UNKNOWN | Immuno-persistence Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls (54m) |
| NCT04952961 | Not specified | COMPLETED | Early Detection of Vulval CAncer Through Self-Examination (EDuCATE): Intervention Study |
| NCT04969445 | Not specified | UNKNOWN | The Durability of Protection Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female |
| NCT05045755 | Not specified | UNKNOWN | The Durability of Protection and Immuno-persistence Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female |
| NCT06297187 | Not specified | COMPLETED | Cavitronic Ultrasonic Surgical Aspiration (CUSA) Women’s Health Study |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| IMIQUIMOD | 4 | 2 |
| HUMAN PAPILLOMAVIRUS, L1 PROTEIN VIRUS LIKE PARTICLES | 4 | 1 |
| METHYL AMINOLEVULINATE HYDROCHLORIDE | 4 | 1 |
| BIZALIMOGENE RALAPLASMID | 3 | 1 |