Vulvar lichen sclerosus
diseaseOn this page
Also known as lichen sclerosus et atrophicus of mammalian vulvamammalian vulva lichen sclerosus et atrophicus
Summary
Vulvar lichen sclerosus (MONDO:0006491) is a disease and 26 clinical trials. Top therapeutic interventions include clobetasol propionate, cortisone acetate, and tacrolimus anhydrous. A subtype of vulvar dystrophy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 26
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | vulvar lichen sclerosus |
| Mondo ID | MONDO:0006491 |
| EFO | EFO:1000623 |
| MeSH | D007724 |
| NCIT | C27723 |
| UMLS | C0022783 |
| MedGen | 7228 |
| Anatomy (UBERON) | UBERON:0000997 |
| Is cancer (heuristic) | no |
Also known as: lichen sclerosus et atrophicus of mammalian vulva · mammalian vulva lichen sclerosus et atrophicus · vulvar lichen sclerosus
Data availability: 1 cell line.
Disease family
This is a subtype of vulvar dystrophy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › vulvar disease › vulvar dystrophy › vulvar lichen sclerosus
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Clobetasol Propionate | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Clobetasol, Progesterone, Tacrolimus Anhydrous.
Clinical trials & evidence
Clinical trials
Clinical trials: 26.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 15 |
| PHASE2 | 5 |
| PHASE1/PHASE2 | 2 |
| PHASE4 | 1 |
| PHASE3 | 1 |
| PHASE2/PHASE3 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04951206 | PHASE4 | COMPLETED | Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus |
| NCT02573883 | PHASE3 | COMPLETED | Clobetasol Propionate Versus Fractionated Carbon Dioxide Laser for the Treatment of Lichen Sclerosus |
| NCT05243563 | PHASE2/PHASE3 | TERMINATED | Does Steroid Plus CO2 Laser Improve Lichen Sclerosus Symptoms Compared to Steroids Alone? |
| NCT04967170 | PHASE1/PHASE2 | ACTIVE_NOT_RECRUITING | A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen Sclerosus |
| NCT06661382 | PHASE1/PHASE2 | RECRUITING | Use of Platelet Rich Plasma from Cord Blood Vs Placebo in the Treatment of Vulvar Lichen Sclerosus |
| NCT07352917 | PHASE2 | RECRUITING | Methotrexate for Severe Vulvar Lichen Sclerosus |
| NCT00757874 | PHASE2 | COMPLETED | Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus |
| NCT01126255 | PHASE2 | TERMINATED | Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus |
| NCT03961126 | PHASE2 | COMPLETED | Evaluation of Vulvar Lichen Sclerosus Treatment Using Adipose Tissue Associated With Autologous Platelet-rich Plasma. |
| NCT06132919 | PHASE2 | COMPLETED | Efficacy and Safety of MC2-25 Cream & Vehicle in Women With Vulvar Lichen Sclerosus (VLS) |
| NCT06662942 | PHASE1 | RECRUITING | StrataMGT in the Reduction of Vulvar Lichen Sclerosus (LS) Symptoms |
| NCT07240389 | Not specified | NOT_YET_RECRUITING | Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy. |
| NCT07240519 | Not specified | RECRUITING | To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment. |
| NCT07363733 | Not specified | RECRUITING | Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus |
| NCT07450625 | Not specified | NOT_YET_RECRUITING | Efficacy of Collagendep in Reducing Vulvar Dryness in Patients With Lichen Sclerosus Treated With Fat Grafting |
| NCT01400022 | Not specified | COMPLETED | Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus |
| NCT02416531 | Not specified | COMPLETED | Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser |
| NCT03686800 | Not specified | COMPLETED | The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients |
| NCT03926299 | Not specified | COMPLETED | Clinical Trial to Demonstrate That the Dual Laser Therapy is Effective for the Treatment of Vulvar Lichen Sclerosus |
| NCT04134494 | Not specified | TERMINATED | Laser Treatment for Vulvar Lichen Sclerosus |
| NCT04148651 | Not specified | COMPLETED | The CO2RE® System for Vulvar Lichen Sclerosus |
| NCT04952961 | Not specified | COMPLETED | Early Detection of Vulval CAncer Through Self-Examination (EDuCATE): Intervention Study |
| NCT05147129 | Not specified | COMPLETED | Characterizing the Microbiome in Postmenopausal Women With Vulvar Lichen Sclerosus |
| NCT05250466 | Not specified | UNKNOWN | A Comparative Study on the Efficacy of AI Temperature-controlled Radiofrequency Technology and Electrical Stimulation in the Treatment of Vulvar Leukoplakia |
| NCT05251220 | Not specified | COMPLETED | Efficacy and Safety of the Neodymium Laser in Treatment of Urogenital Tract Diseases in Women |
| NCT06360705 | Not specified | COMPLETED | StrataMGT for the Treatment of Vulvar Lichen Sclerosus |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CLOBETASOL PROPIONATE | 4 | 7 |
| CORTISONE ACETATE | 4 | 1 |
| TACROLIMUS ANHYDROUS | 4 | 1 |
| CLOBETASOL | 3 | 1 |
| CORTISONE | 3 | 1 |
| CHEMBL1497313 | 0 | 1 |