Vulvar neoplasm
disease diseaseOn this page
Also known as mammalian vulva neoplasmmammalian vulva neoplasm (disease)mammalian vulva tumormammalian vulva tumourneoplasm of mammalian vulvaneoplasm of the vulvaneoplasm of vulvatumor of mammalian vulvatumor of the vulvatumor of vulvatumour of mammalian vulvatumour of the vulvatumour of vulvavulva neoplasmvulva tumorvulva tumourvulval neoplasmvulvar tumorvulvar tumour
Summary
Vulvar neoplasm (MONDO:0021049) is a cancer (an umbrella term covering 9 Mondo subtypes) and 18 clinical trials. Top therapeutic interventions include hydroxyzine, loperamide, and prochlorperazine. A subtype of vulvar disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 9 Mondo subtypes
- Clinical trials: 18
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | vulvar neoplasm |
| Mondo ID | MONDO:0021049 |
| NCIT | C3443 |
| SNOMED CT | 126922007 |
| UMLS | C0042995 |
| MedGen | 22689 |
| Anatomy (UBERON) | UBERON:0000997 |
| Is cancer (heuristic) | yes |
Also known as: mammalian vulva neoplasm · mammalian vulva neoplasm (disease) · mammalian vulva tumor · mammalian vulva tumour · neoplasm of mammalian vulva · neoplasm of the vulva · neoplasm of vulva · tumor of mammalian vulva · tumor of the vulva · tumor of vulva · tumour of mammalian vulva · tumour of the vulva · tumour of vulva · vulva neoplasm · vulva tumor · vulva tumour · vulval neoplasm · vulvar neoplasm · vulvar tumor · vulvar tumour
Disease family
This is a subtype of vulvar disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › vulvar disease › vulvar neoplasm
Related subtypes (3): ulceration of vulva, vulvar dystrophy, vulvitis
Subtypes (9): vulvar benign neoplasm, vulva cancer, vulvar squamous neoplasm, vulvar glandular neoplasm, paraurethral gland neoplasm, vulvar granular cell tumor, germ cell tumor of the vulva, Bartholin gland neoplasm, clitoris neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 18.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 11 |
| PHASE3 | 2 |
| PHASE1/PHASE2 | 2 |
| PHASE2 | 2 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00224744 | PHASE3 | COMPLETED | Prospective and Randomized Study to Evaluate Interest of Ultracision Use in Inguinal Lymph Nodes Curage |
| NCT03546842 | PHASE3 | COMPLETED | Safety and Immunogenicity Study of V503 (GARDASIL™9, 9vHPV Vaccine) Administered to 9- to 26-Year-Old Females and Males in Vietnam (V503-017) |
| NCT05592626 | PHASE1/PHASE2 | RECRUITING | A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors |
| NCT06638931 | PHASE2 | RECRUITING | Agnostic Therapy in Rare Solid Tumors |
| NCT02858310 | PHASE1/PHASE2 | COMPLETED | E7 TCR T Cells for Human Papillomavirus-Associated Cancers |
| NCT05761132 | PHASE2 | UNKNOWN | Neo-adjuvant Pembrolizumab in Vulvar Squamous Cell Carcinoma: a Clinical Proof-of-concept Study |
| NCT05578820 | PHASE1 | COMPLETED | Safety, Tolerability and Pharmacokinetics Investigation of Stimotimagene Copolymerplasmid |
| NCT05934851 | Not specified | ACTIVE_NOT_RECRUITING | A Study Evaluating the Effect of Frozen-Section Directed Excision Surgery on Vulvar Dysplasia |
| NCT06132321 | Not specified | RECRUITING | Quality of Life in Patients Undergone Vulvar Reconstruction After Vulvar Cancer Resection (3233) |
| NCT06495554 | Not specified | RECRUITING | Danish Vulva Cancer Recurrence Study |
| NCT00112307 | Not specified | COMPLETED | Magnetic Resonance Imaging Guided Gynecologic Brachytherapy |
| NCT00288821 | Not specified | COMPLETED | Diagnostic Imaging of Lymph Nodes in Gynaecologic Oncology |
| NCT00391664 | Not specified | UNKNOWN | Questionnaire Study for Gynecological Cancer Survivors |
| NCT02067052 | Not specified | UNKNOWN | New Strategy for the Treatment of Vulvar Cancer |
| NCT02786524 | Not specified | COMPLETED | Effect of Outpatient Symptom Management on Gynecologic Oncology Patients Receiving Chemotherapy |
| NCT03000192 | Not specified | UNKNOWN | HORIZONS: Understanding the Impact of Cancer Diagnosis and Treatment on Everyday Life |
| NCT04351139 | Not specified | COMPLETED | Impact of the COVID-19 Pandemic in Gynecological Oncology |
| NCT04541784 | Not specified | COMPLETED | Effectiveness of an App Intervention to Reduce Postsurgical Symptom Distress in Patients With Vulvar Neoplasia |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| HYDROXYZINE | 4 | 3 |
| LOPERAMIDE | 4 | 3 |
| PROCHLORPERAZINE | 4 | 3 |
| ATROPINE SULFATE | 4 | 1 |
| CODEINE SULFATE | 4 | 1 |
| DIPHENHYDRAMINE HYDROCHLORIDE | 4 | 1 |
| DIPHENOXYLATE HYDROCHLORIDE | 4 | 1 |
| DROPERIDOL | 4 | 1 |
| FLUDARABINE PHOSPHATE | 4 | 1 |
| GANCICLOVIR | 4 | 1 |
| GRANISETRON | 4 | 1 |
| INDOMETHACIN | 4 | 1 |
| MEPERIDINE | 4 | 1 |
| CHEMBL284671 | 0 | 1 |
| CHEMBL399538 | 0 | 1 |