Vulvodynia
disease diseaseOn this page
Summary
Vulvodynia (MONDO:0021722) is a disease and 70 clinical trials. Top therapeutic interventions include amitriptyline, sodium chloride, and apremilast. A subtype of female reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 70
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | vulvodynia |
| Mondo ID | MONDO:0021722 |
| MeSH | D056650 |
| ICD-10-CM | N94.81 |
| ICD-11 | 1539507119 |
| SNOMED CT | 238968009 |
| UMLS | C0406670 |
| MedGen | 96066 |
| Anatomy (UBERON) | UBERON:0000997 |
| Is cancer (heuristic) | no |
Also known as: vulvodynia
Disease family
This is a subtype of female reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › vulvodynia
Related subtypes (33): ectopic pregnancy, pelvic inflammatory disease, endosalpingiosis, vaginal disorder, prolapse of female genital organ, Allen-Masters syndrome, fallopian tube disorder, vulvar disease, uterine disorder, gynatresia, Bartholin duct cyst, ovarian disorder, hymen, imperforate, preterm premature rupture of the membranes, mammary-digital-nail syndrome, Asherman syndrome, uterine cervical aplasia and agenesis, longitudinal vaginal septum, transverse vaginal septum, polycystic ovaries-urethral sphincter dysfunction syndrome, granulomatous mastitis, vaginal atresia, mullerian aplasia, vulvovaginal gingival syndrome, isolated partial vaginal agenesis, female infertility, female reproductive system neoplasm, polyp of vulva, vulval varices, menstrual cycle-dependent periodic fever, Bartholin’s gland disease, delayed puberty, self-limited, menstrual disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 70.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 51 |
| PHASE2 | 10 |
| PHASE3 | 7 |
| PHASE2/PHASE3 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07260825 | PHASE2/PHASE3 | NOT_YET_RECRUITING | Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial |
| NCT00496184 | PHASE3 | COMPLETED | Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis |
| NCT01304589 | PHASE3 | COMPLETED | Savella in Treatment for Provoked Vestibulodynia |
| NCT01539317 | PHASE3 | COMPLETED | Therapy to Prevent Sexual Pain in Breast Cancer Survivors |
| NCT02393911 | PHASE3 | UNKNOWN | Dysbiosis in Localized Provoked Vulvodynia (LPV) |
| NCT02773641 | PHASE3 | COMPLETED | Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia |
| NCT02871661 | PHASE3 | UNKNOWN | Physical Therapy as Adjuvant Treatment of Vulvodynia: a Randomized Controled Trial |
| NCT04057755 | PHASE3 | COMPLETED | Botulinum Toxin A as a Treatment for Provoked Vestibulodynia |
| NCT05955313 | PHASE2 | RECRUITING | Effectiveness of Low-dose Naltrexone in Patients With Different Types of Vulvodynia |
| NCT07257029 | PHASE2 | RECRUITING | Topical Ketotifen 0.25% for Secondary Vestibulodynia |
| NCT07391241 | PHASE2 | RECRUITING | A Phase 2 Study to Evaluate the Efficacy and Safety of Pudafensine in Vulvodynia (Provoked Vestibulodynia) |
| NCT00590590 | PHASE2 | COMPLETED | Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort |
| NCT00814632 | PHASE2 | COMPLETED | CC-10004 For The Treatment Of Vulvodynia |
| NCT00853229 | PHASE2 | TERMINATED | Pregabalin for the Treatment of Vulvodynia |
| NCT00874484 | PHASE2 | COMPLETED | Enoxaparin as Treatment for Vulvodynia |
| NCT01048177 | PHASE2 | WITHDRAWN | A Trial of Intravesical Therapy for Interstitial Cystitis in Patients With Generalized Vulvodynia |
| NCT03598777 | PHASE2 | TERMINATED | Dysport in Vulvodynia Phase II Study |
| NCT03682601 | PHASE2 | TERMINATED | Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment |
| NCT01996384 | PHASE1 | COMPLETED | Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study |
| NCT01829204 | Not specified | RECRUITING | Prospective Data Bank Creation to Study Vaginal Conditions |
| NCT03640624 | Not specified | ACTIVE_NOT_RECRUITING | Multidisciplinary Treatment of Chronic Vulvar Pain |
| NCT04711369 | Not specified | RECRUITING | Lasertherapy for Vulvodynia |
| NCT05324280 | Not specified | RECRUITING | Acupuncture in a Multidisciplinary Approach for Vulvodynia and Chronic Pelvic Pain |
| NCT05343182 | Not specified | RECRUITING | Vestibulectomy Surgical Techniques Comparison Study |
| NCT05597358 | Not specified | ACTIVE_NOT_RECRUITING | Efficacy of High Intensity Laser for Provoked Vestibulodynia |
| NCT06337448 | Not specified | NOT_YET_RECRUITING | Light Emitting Diode in the Treatment of Vulvodynia |
| NCT06472765 | Not specified | ENROLLING_BY_INVITATION | Vaginal Ecosystem and Network in the United States Study |
| NCT06660212 | Not specified | RECRUITING | Biomodulation and Rehabilitation Interventions to tarGet Pelvic Health |
| NCT06840314 | Not specified | RECRUITING | VIBRating vs Traditional Therapy for Treatment of ENTry Dyspareunia |
| NCT06865963 | Not specified | RECRUITING | Vestibulodynia At High Resolution: Omics Approach to Improve Diagnosis |
| NCT06981611 | Not specified | RECRUITING | Vulvodynia Intervention: the Effect of Multimodal Treatment for Provoked Vulvodynia |
| NCT06999395 | Not specified | RECRUITING | Does a Virtual Program for Pelvic Pain Improve Pain and Sexual Outcomes in Individuals With Provoked Vestibulodynia? |
| NCT07092332 | Not specified | RECRUITING | Young Vulvodynia: Effect and Efficacy of Multimodal Treatment. |
| NCT07553715 | Not specified | NOT_YET_RECRUITING | Effectiveness of a Four-Session Focal Shock Wave Therapy Protocol in Women With Vulvodynia |
| NCT00390013 | Not specified | TERMINATED | To Evaluate if the Medication Gabapentin Lessens Vulvar Pain |
| NCT00501774 | Not specified | COMPLETED | A Search for Helicobacter Pylori in Localized Vulvodynia |
| NCT00607490 | Not specified | COMPLETED | A Randomized Clinical Trial for Women With Vulvodynia |
| NCT00751010 | Not specified | COMPLETED | Relationship: Interstitial Cystitis & Vulvodynia-Part 2 |
| NCT00873301 | Not specified | COMPLETED | The Effectiveness of Vestibulectomy |
| NCT01295268 | Not specified | TERMINATED | Study of Emu Oil vs. Placebo for Vulvar Pain in Women. |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| AMITRIPTYLINE | 4 | 3 |
| SODIUM CHLORIDE | 4 | 2 |
| APREMILAST | 4 | 1 |
| DIPHENHYDRAMINE | 4 | 1 |
| KETOTIFEN FUMARATE | 4 | 1 |
| MILNACIPRAN | 4 | 1 |
| TESTOSTERONE | 4 | 1 |
| PUDAFENSINE | 2 | 1 |
| CHEMBL4746472 | 0 | 1 |
| 1R,2S-MILNACIPRAN | 0 | 1 |