Xerophthalmia

Summary

Xerophthalmia (MONDO:0000948) is a disease and 10 clinical trials. A subtype of dry eye syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 10

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	xerophthalmia
Mondo ID	MONDO:0000948
MeSH	D014985
DOID	DOID:10138
NCIT	C34503
SNOMED CT	363677007
UMLS	C0022575
MedGen	9620
GARD	0027564
Is cancer (heuristic)	no

Also known as: conjunctival xerosis

Disease family

This is a subtype of dry eye syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye adnexa disorder › lacrimal apparatus disorder › dry eye syndrome › xerophthalmia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7
PHASE1	2
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00796926	PHASE3	COMPLETED	Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes
NCT06263998	PHASE1	RECRUITING	Clinical Study for the Evaluation of Safety and Tolerability of NCP112 Eye Drops
NCT01089985	PHASE1	COMPLETED	Use of Autologous Serum Eye-drops as Tears in Patients With Recalcitrant Dry Eye
NCT06475027	Not specified	NOT_YET_RECRUITING	Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren’s Syndrome
NCT06771427	Not specified	RECRUITING	Exosomes Proteomic for Sjogren’s Syndrome and Dry Eye Syndrome
NCT02655432	Not specified	WITHDRAWN	Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population
NCT03753893	Not specified	COMPLETED	Ocular Manifestations in Rheumatic Diseases
NCT04636372	Not specified	WITHDRAWN	Effect of Meibomian Gland Related Therapy on the Morphology of Meibomian Gland
NCT04877483	Not specified	UNKNOWN	To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome
NCT05656196	Not specified	COMPLETED	VGH-DESJS-1 in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome and Sjögren’s Syndrome