Yaws

Summary

Yaws (MONDO:0006019) is a disease and 14 clinical trials. Top therapeutic interventions include ivermectin, albendazole, and azithromycin. A subtype of syphilis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 14

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	yaws
Mondo ID	MONDO:0006019
MeSH	D015001
DOID	DOID:10371
ICD-10-CM	A66
ICD-11	840525023
NCIT	C41353
SNOMED CT	70647001
UMLS	C0043388
MedGen	12186
GARD	0007913
NORD	1872
Is cancer (heuristic)	no

Also known as: Bouba · endemic treponematoses · frambesia · frambesia tropica · Treponema pallidum subsp. pertenue caused disease or disorder · Treponema pallidum subsp. pertenue disease or disorder · Treponema pallidum subsp. pertenue infectious disease · Treponema pertenue infection

Disease family

This is a subtype of syphilis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › syphilis › yaws

Related subtypes (9): bejel, primary syphilis, secondary syphilis, tertiary syphilis, congenital syphilis, latent syphilis, cutaneous syphilis, syphilitic aortitis, chancre

Subtypes (4): late yaws, early yaws, latent yaws, tertiary lesion of yaws

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Azithromycin	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	5
Not specified	5
PHASE4	2
PHASE2	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02775617	PHASE4	COMPLETED	Azithromycin - Ivermectin Mass Drug Administration for Skin Disease
NCT03490123	PHASE4	COMPLETED	Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication
NCT01382004	PHASE3	COMPLETED	Single-dose Azithromycin for the Treatment of Yaws
NCT01955252	PHASE3	COMPLETED	Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea
NCT02344628	PHASE3	COMPLETED	Comparison of Two Different Doses of Azithromycin for Treatment of Yaws
NCT03676140	PHASE3	COMPLETED	Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )
NCT05764876	PHASE3	COMPLETED	Repurposing Clinically Approved Drugs for Yaws with an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws)
NCT03664063	PHASE2	COMPLETED	PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs )
NCT04453124	PHASE2	COMPLETED	An Accessible Low-cost Plant Treatment for Cutaneous Ulcers
NCT07248462	Not specified	NOT_YET_RECRUITING	Integrating Mental Health Into Neglected Tropical Disease Care in Ghana
NCT07506967	Not specified	NOT_YET_RECRUITING	Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
NCT01841203	Not specified	COMPLETED	Dual Point-of-care Test for the Diagnosis of Yaws
NCT03683745	Not specified	COMPLETED	Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia
NCT04753788	Not specified	COMPLETED	Evaluation of a LAMP Assay for T. Pallidum. Pertenue

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
IVERMECTIN	4	2
ALBENDAZOLE	4	1
AZITHROMYCIN	4	1
DIETHYLCARBAMAZINE	4	1
LINEZOLID	4	1
PERMETHRIN	4	1
CHEMBL263291	0	2
CHEMBL4082099	0	2
CHEMBL4788951	0	2
CHEMBL4299381	0	1