Zika virus infectious disease
diseaseOn this page
Also known as congenital Zika syndromecongenital Zika virus infectionfever, ZikaZikaZika feverZika virus caused disease or disorderZika virus diseaseZika virus disease or disorderZika virus infectionZikV infection
Summary
Zika virus infectious disease (MONDO:0018661) is a disease and 47 clinical trials. Top therapeutic interventions include sodium chloride and japanese encephalitis virus, inactivated. A subtype of Flaviviridae infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide) [Orphanet-validated]
- Phenotypes (HPO): 34
- Clinical trials: 47
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | 1-5 / 10 000 | 58.8 | Brazil | Validated |
Signs & symptoms
Clinical features (HPO)
34 HPO clinical features (Orphanet curated; top 34 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000988 | Skin rash | Very frequent (80-99%) |
| HP:0040186 | Maculopapular exanthema | Very frequent (80-99%) |
| HP:0000509 | Conjunctivitis | Frequent (30-79%) |
| HP:0000989 | Pruritus | Frequent (30-79%) |
| HP:0001369 | Arthritis | Frequent (30-79%) |
| HP:0001945 | Fever | Frequent (30-79%) |
| HP:0002315 | Headache | Frequent (30-79%) |
| HP:0002829 | Arthralgia | Frequent (30-79%) |
| HP:0002921 | Abnormality of the cerebrospinal fluid | Frequent (30-79%) |
| HP:0003326 | Myalgia | Frequent (30-79%) |
| HP:0003496 | Increased circulating IgM level | Frequent (30-79%) |
| HP:0000969 | Edema | Occasional (5-29%) |
| HP:0001225 | Wrist swelling | Occasional (5-29%) |
| HP:0001785 | Ankle swelling | Occasional (5-29%) |
| HP:0002013 | Vomiting | Occasional (5-29%) |
| HP:0012779 | Transient hearing impairment | Occasional (5-29%) |
| HP:0000252 | Microcephaly | Very rare (<1-4%) |
| HP:0000533 | Chorioretinal atrophy | Very rare (<1-4%) |
| HP:0000612 | Iris coloboma | Very rare (<1-4%) |
| HP:0001132 | Lens subluxation | Very rare (<1-4%) |
| HP:0001287 | Meningitis | Very rare (<1-4%) |
| HP:0001511 | Intrauterine growth retardation | Very rare (<1-4%) |
| HP:0001873 | Thrombocytopenia | Very rare (<1-4%) |
| HP:0001933 | Subcutaneous hemorrhage | Very rare (<1-4%) |
| HP:0002383 | Infectious encephalitis | Very rare (<1-4%) |
| HP:0005268 | Spontaneous abortion | Very rare (<1-4%) |
| HP:0006906 | Congenital intracerebral calcification | Very rare (<1-4%) |
| HP:0007131 | Acute demyelinating polyneuropathy | Very rare (<1-4%) |
| HP:0007401 | Macular atrophy | Very rare (<1-4%) |
| HP:0007766 | Optic disc hypoplasia | Very rare (<1-4%) |
| HP:0007814 | Retinal pigment epithelial mottling | Very rare (<1-4%) |
| HP:0012486 | Myelitis | Very rare (<1-4%) |
| HP:0012795 | Abnormality of the optic disc | Very rare (<1-4%) |
| HP:0030825 | Absent foveal reflex | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | Zika virus infectious disease |
| Mondo ID | MONDO:0018661 |
| MeSH | D000071243 |
| Orphanet | 448237 |
| DOID | DOID:0060478 |
| ICD-10-CM | A92.5 |
| ICD-11 | 1401438580 |
| NCIT | C128423 |
| SNOMED CT | 3928002 |
| UMLS | C0276289 |
| MedGen | 547236 |
| GARD | 0012894 |
| Is cancer (heuristic) | no |
Also known as: congenital Zika syndrome · congenital Zika virus infection · fever, Zika · Zika · Zika fever · Zika virus caused disease or disorder · Zika virus disease · Zika virus disease or disorder · Zika virus infection · Zika virus infectious disease · ZikV infection
Disease family
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Flaviviridae infectious disease › Zika virus infectious disease
Related subtypes (9): Powassan encephalitis, Murray valley encephalitis, West Nile fever, dengue disease, pestivirus infectious disease, st. Louis encephalitis, Kyasanur forest disease, Omsk hemorrhagic fever, yellow fever
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 47.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 33 |
| PHASE1 | 13 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03110770 | PHASE2 | COMPLETED | VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents |
| NCT02887482 | PHASE1 | COMPLETED | GLS-5700 in Dengue Virus Seropositive Adults |
| NCT02937233 | PHASE1 | COMPLETED | Zika Virus Purified Inactivated Vaccine (ZPIV) Accelerated Vaccination Schedule Study |
| NCT02952833 | PHASE1 | COMPLETED | ZIKA Vaccine in Naive Subjects |
| NCT02963909 | PHASE1 | COMPLETED | A Phase 1, First-in-human, Double-blinded, Randomized, Placebo-controlled Trial of a Zika Virus Purified Inactivated Vaccine (ZPIV) With Alum Adjuvant in Healthy Flavivirus-naive and Flavivirus-Primed Subjects. |
| NCT03008122 | PHASE1 | COMPLETED | Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) in Adults in a Flavivirus Endemic Area |
| NCT03343626 | PHASE1 | COMPLETED | Safety, Immunogenicity, and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Participants |
| NCT03425149 | PHASE1 | COMPLETED | Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults |
| NCT03624946 | PHASE1 | COMPLETED | Study in Healthy Volunteers Evaluating Safety and Pharmacokinetics of Zika Virus Immune Globulin (ZIKV-IG) |
| NCT04015648 | PHASE1 | COMPLETED | Safety and Immunogenicity of a Candidate ZIKV Vaccine (ZIKA001) |
| NCT04033068 | PHASE1 | COMPLETED | Safety and Immunogenicity of a Novel Vaccine Formulation MV-ZIKA-RSP (V187-001) |
| NCT04440774 | PHASE1 | COMPLETED | Research Study to Assess New Chikungunya and Zika Vaccines in Healthy Adults in Mexico. |
| NCT04478656 | PHASE1 | COMPLETED | Safety and Immunogenicity of BBV121 |
| NCT06334393 | PHASE1 | COMPLETED | Phase 1 Trial to Assess the Safety and Immunogenicity of an Inactivated, Adjuvanted Whole Zika Virus Vaccine Candidate (VLA1601) in Healthy Adults |
| NCT01386424 | Not specified | RECRUITING | Screening for LID Clinical Studies Unit Healthy Volunteer Protocols |
| NCT04398901 | Not specified | ENROLLING_BY_INVITATION | Neurodevelopmental Outcomes in ZIKV-Exposed Children |
| NCT04615364 | Not specified | RECRUITING | Genetic Evolution of Arboviruses in New Caledonia Between 1995 and 2024 and Impact of Wolbachia |
| NCT04619823 | Not specified | RECRUITING | Virological and Immunological Determinants of Arbovirus Infection in New Caledonia |
| NCT07358910 | Not specified | RECRUITING | Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective |
| NCT07520279 | Not specified | ENROLLING_BY_INVITATION | Xpert® Tropical Fever Test on GeneXpert® Edge X System |
| NCT02733796 | Not specified | COMPLETED | Persistence of Zika Virus in Semen After Acute Infection |
| NCT02831699 | Not specified | COMPLETED | The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico |
| NCT02856984 | Not specified | COMPLETED | Zika in Infants and Pregnancy (ZIP) |
| NCT03055585 | Not specified | TERMINATED | Applying Wolbachia to Eliminate Dengue |
| NCT03158233 | Not specified | COMPLETED | Zika Case Definition and Surveillance Study |
| NCT03161444 | Not specified | TERMINATED | Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. |
| NCT03204409 | Not specified | WITHDRAWN | ZIKAlliance Natural History Study |
| NCT03206541 | Not specified | COMPLETED | Neurologic Manifestations of the Arbovirus Infection in Colombia |
| NCT03255369 | Not specified | UNKNOWN | Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) |
| NCT03330600 | Not specified | COMPLETED | Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome |
| NCT03631719 | Not specified | COMPLETED | Impact of Wolbachia Deployment on Arboviral Disease Incidence in Medellin and Bello, Colombia |
| NCT03641339 | Not specified | COMPLETED | Defining Skin Immunity of a Bite of Key Insect Vectors in Humans |
| NCT03679728 | Not specified | COMPLETED | Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection |
| NCT03776903 | Not specified | COMPLETED | Evaluation of the Clinical Performance of the ZIKV Detect™ 2.0 IgM Capture ELISA |
| NCT04118738 | Not specified | COMPLETED | International Cohort Study of Children Born to Women Infected With Zika Virus During Pregnancy |
| NCT04343521 | Not specified | COMPLETED | Quantifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases |
| NCT04434846 | Not specified | COMPLETED | Sylvatic Transmission of Zika, Dengue, and Chikungunya Viruses in Thailand and Cambodia |
| NCT04672577 | Not specified | UNKNOWN | Infection Tracking in Travellers. The Project Aims to Identify Profiles of Travel-associated Illness and to Follow up on Long-term Sequelae of Arboviral Infections and Malaria |
| NCT04697147 | Not specified | COMPLETED | Zika and Neurodevelopment Among Infants in Grenada |
| NCT05041439 | Not specified | COMPLETED | Adherence to Care for Children With Congenital Zika Virus Infection in Puerto Rico |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| SODIUM CHLORIDE | 4 | 2 |
| JAPANESE ENCEPHALITIS VIRUS, INACTIVATED | 4 | 1 |
| CHEMBL283807 | 0 | 1 |