Benzoyl Peroxide
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Also known as Acetoxyl 2.5Acetoxyl 5AcnecideAcnecide 10AcnegelAcnegel fteAcnidazilAnhydrous benzoyl peroxideBenoxyl 10Benoxyl 20Benoxyl 5Benzagel 10Benzagel 5BenzamycinBenzoyl peroxide anhydrousBenzoyl peroxide component of acanyaBenzoyl peroxide component of aktipakBenzoyl peroxide component of benzaclinBenzoyl peroxide component of benzamycin
Summary
Benzoyl Peroxide (CHEMBL1200370) is an approved small molecule (ATC D10AE01); indicated across 5 conditions including acne and molluscum contagiosum.
At a glance
- Status: Approved (max clinical phase 4)
- Modality: Small molecule
- ATC class: D10AE01 (+1 more)
- Indications: 5 conditions
- Clinical trials: 33
- Chemistry: 242.23 Da · C14H10O4
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL1200370 |
| Name | Benzoyl Peroxide |
| Type | Small molecule |
| Max phase | 4 |
| FDA approved | yes |
| PubChem CID | 7187 |
| ATC | D10AE01, D10AE51 |
| Molecular formula | C14H10O4 |
| Molecular weight | 242.23 |
| InChIKey | OMPJBNCRMGITSC-UHFFFAOYSA-N |
SMILES: C1=CC=C(C=C1)C(=O)OOC(=O)C2=CC=CC=C2
IUPAC name: benzoyl benzenecarboperoxoate
Also known as: Acetoxyl 2.5, Acetoxyl 5, Acnecide, Acnecide 10, Acnegel, Acnegel fte, Acnidazil, Anhydrous benzoyl peroxide, Benoxyl 10, Benoxyl 20, Benoxyl 5, Benzagel 10
Patent coverage: 143,917 distinct patent families (354,767 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.
Targets
Targets
Broader ChEMBL bioactivity targets: 2 (assay-derived). Sample: Prelamin-A/C, Prothrombin.
Bioactivity
ChEMBL activities: 2 potent at pChembl ≥ 5 of 2 total. Top 30 by potency (10 = 0.1 nM, 6 = 1 µM):
| Target | pChembl | Type | Value | Unit | Activity ID |
|---|---|---|---|---|---|
| LMNA | 8.2 | Potency | 6.3 | nM | CHEMBL_ACT_3643999 |
| F2 | 5.04 | AC50 | 9020 | nM | CHEMBL_ACT_25196869 |
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
5 indications (1 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| acne | 4 | MONDO:0011438 | EFO:0003894 |
| molluscum contagiosum | 3 | MONDO:0005855 | EFO:0007375 |
| actinic keratosis | 2 | MONDO:0005173 | EFO:0002496 |
| rosacea | 1 | MONDO:0006604 | EFO:1000760 |
1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 33.
Phase distribution
| Phase | Trials |
|---|---|
| PHASE4 | 15 |
| PHASE3 | 10 |
| Not specified | 5 |
| PHASE2 | 2 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00658112 | PHASE4 | COMPLETED | Measuring Adherence in Subjects With Acne Vulgaris in a Clinic Population Subtitle: Topical Benzoyl Peroxide for Acne |
| NCT00887484 | PHASE4 | COMPLETED | A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne |
| NCT00919191 | PHASE4 | COMPLETED | Evaluation of Irritation by Two Facial Gels Applied to Opposite Sides of the Face |
| NCT00926367 | PHASE4 | COMPLETED | Two-week Study to Compare the Tolerance and Irritation Potential of Two Combination Topical Gel Acne Medications |
| NCT00964223 | PHASE4 | COMPLETED | A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne |
| NCT00964366 | PHASE4 | COMPLETED | Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications |
| NCT01138735 | PHASE4 | COMPLETED | Epiduo Pediatric Acne Study |
| NCT01206348 | PHASE4 | COMPLETED | Combination Treatment for Moderate to Severe Acne |
| NCT01260571 | PHASE4 | UNKNOWN | Clinical Study to Evaluate the Efficacy of Topical Medications Containing Benzoyl Peroxide and Sulfur in the Regression in the Short Time (24 Hours) of Moderate Acne Vulgaris Grade II (Pimples) |
| NCT01448733 | PHASE4 | UNKNOWN | Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne Vulgaris |
| NCT01613924 | PHASE4 | WITHDRAWN | Efficacy of Handheld Acne Heat Device |
| NCT02589405 | PHASE4 | COMPLETED | Benzac 5% Gel in Combination With Cosmetic Products in Acne Vulgaris |
| NCT04021524 | PHASE4 | COMPLETED | BPO vs Hibiclens Soap for Surgical Preparation |
| NCT04548349 | PHASE4 | COMPLETED | Profiling the Skin Microbiome in Response to Altreno in Acne Patients |
| NCT05676411 | PHASE4 | WITHDRAWN | Benzoyl Peroxide and Electrocautery Skin Incision to Eradicate Cutibacterium Acnes |
| NCT00421993 | PHASE3 | COMPLETED | A Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris |
| NCT00422240 | PHASE3 | COMPLETED | Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris |
| NCT00446043 | PHASE3 | COMPLETED | Long-term Study of Efficacy/Safety of Adapalene/Benzoyl Peroxide Topical Gel in Acne Vulgaris Subjects |
| NCT00663286 | PHASE3 | COMPLETED | A Clinical Trial Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris |
| NCT00664248 | PHASE3 | COMPLETED | A Clinical Study Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris |
| NCT00869492 | PHASE3 | UNKNOWN | Comparison of Nadifloxacin Cream Alone and With Benzoyl Peroxide Solution in the Treatment of Acne |
| NCT00877409 | PHASE3 | UNKNOWN | Safety and Efficacy Study of Acnase Creme in the Treatment of Acne Vulgaris I and II |
| NCT02465632 | PHASE3 | COMPLETED | To Study Generic Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Glenmark Generics, Ltd) in the Treatment of Acne Vulgaris. |
| NCT05536882 | PHASE3 | WITHDRAWN | MC RCT - BPO vs Adapalene |
| NCT05629468 | PHASE3 | COMPLETED | Comparing Efficacy of Azithromycin and Probiotics for Treatment of Acne Vulgaris |
| NCT07032649 | PHASE2 | NOT_YET_RECRUITING | Evaluating Benzoyl Peroxide for Preventing Recurrence of HSV-1 Outbreaks With Rescue Crossover Option |
| NCT03257202 | PHASE2 | COMPLETED | Topical Treatment and Prevalence of P. Acnes |
| NCT01428466 | PHASE1 | COMPLETED | Japanese Phase 1 Study of GSK2585823 |
| NCT00558831 | Not specified | COMPLETED | Study of Benzoyl Peroxide Cream for Mild to Moderate Acne Vulgaris |
| NCT00787943 | Not specified | COMPLETED | Study of Two Different 10.0% Benzoyl Peroxide Creams for Mild to Moderate Acne Vulgaris |
| NCT01052246 | Not specified | COMPLETED | Pulsed Dye Laser Treatment of Acne Vulgaris |
| NCT01176955 | Not specified | COMPLETED | A Novel Method to Improve Acne Outcomes |
| NCT05355844 | Not specified | UNKNOWN | Cutibacterium Acnes in Deep Tissues in Primary Spine and Shoulder Surgery |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No CPIC/DPWG dosing guideline or drug-level clinical/variant annotations in PharmGKB for this molecule.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: acne, molluscum contagiosum