Calcium Carbonate

Summary

Calcium Carbonate (CHEMBL1200539) is an approved small-molecule antacid (ATC A02AC01); indicated across 31 conditions including anemia and osteoporosis.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: A02AC01 (+1 more)
• Indications: 31 conditions
• Clinical trials: 109
• Chemistry: 100.09 Da · CCaO3

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1200539
Name	Calcium Carbonate
Type	Small molecule
Max phase	4
FDA approved	yes
PubChem CID	10112
ChEBI	CHEBI:3311
ATC	A02AC01, A12AA04
Molecular formula	CCaO3
Molecular weight	100.09
InChIKey	VTYYLEPIZMXCLO-UHFFFAOYSA-L

SMILES: C(=O)([O-])[O-].[Ca+2]

IUPAC name: calcium carbonate

ChEBI definition: A calcium salt with formula CCaO3.

Pharmacological roles (ChEBI): antacid.

Other ChEBI roles (chemical / environmental): food colouring, food firming agent, fertilizer.

Also known as: Adcal, Albacar, Cacit, Calc 500, Calcette, Calcichew, Calcichew fte, Calcidrink, Calcii carbonas, Calcite, Calcite (ca(co3)), Calcitum

Patent coverage: 515,563 distinct patent families (1,186,534 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

2 approved indications. FDA phase 4, plus an anticancer drug’s labelled cancer uses (which ChEMBL often logs at phase 3).

Indication	Phase	MONDO	EFO
anemia	4	MONDO:0002280	EFO:0004272
osteoporosis	4	MONDO:0005298	EFO:0003882

21 diseases in clinical trials (phase 1–3, investigational — not approved indications). Highest ChEMBL trial phase per disease; a non-cancer approved use is occasionally logged at phase 3 here.

Disease (in trials)	Phase	MONDO	EFO
cirrhosis of liver	3	MONDO:0005155	EFO:0001422
vitamin D deficiency	3	MONDO:0100471	EFO:0003762
postmenopausal osteoporosis	3	MONDO:0008159	EFO:0003854
non-Hodgkin lymphoma	3	MONDO:0018908	EFO:0005952
diarrheal disease	3	MONDO:0001673	HP:0002014
alcohol abuse	3	MONDO:0002046	MONDO:0007079
lymphoma	3	MONDO:0005062	EFO:0000574
hyperphosphatemia	3	MONDO:0000328	MONDO:0000328
diabetic kidney disease	2	MONDO:0005016	EFO:0000401
chronic kidney disease	2	MONDO:0005300	EFO:0003884
HIV infectious disease	2	MONDO:0005109	EFO:0000180
juvenile idiopathic arthritis	2	MONDO:0011429	EFO:0002609
breast neoplasm	2	MONDO:0021100	EFO:0003869
obesity disorder	2	MONDO:0011122	EFO:0001073
renal osteodystrophy	2	MONDO:0006946	EFO:1001152
neoplasm	2	MONDO:0005070	MONDO:0004992
secondary hyperparathyroidism	2	MONDO:0006964	EFO:1001173
colonic neoplasm	1	MONDO:0005401	EFO:0004288
radius fracture	1	MONDO:0005325	EFO:0003957
hypoparathyroidism	1	MONDO:0001220	EFO:0009451
gastroesophageal reflux disease	1	MONDO:0007186	EFO:0003948

6 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 109.

Phase distribution

Phase	Trials
Not specified	36
PHASE2	22
PHASE4	19
PHASE3	18
PHASE1	9
PHASE2/PHASE3	3
EARLY_PHASE1	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06580782	PHASE4	RECRUITING	Calcium Carbonate to Augment Labor Contractions
NCT06660524	PHASE4	RECRUITING	Calcium-Phosphorus Regulation Therapy on Heart Valve Disease
NCT00592917	PHASE4	COMPLETED	OSTPRE-Fracture Prevention Study
NCT00785473	PHASE4	COMPLETED	Can Vitamin D Supplementation Prevent Bone Loss in Persons With Multiple Sclerosis
NCT01067898	PHASE4	COMPLETED	A Study on Oral Vitamin D Megadoses
NCT01447433	PHASE4	COMPLETED	Effect of Calcium + Vitamin D Supplementation on Weight Management in Very-low Calcium Consumers
NCT01578434	PHASE4	COMPLETED	Role of Calcium And Vitamin D In Nutritional Rickets And It’s Management
NCT01748396	PHASE4	COMPLETED	Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol
NCT01845090	PHASE4	UNKNOWN	The Effect of Lanthanum Carbonate on Fibroblast Growth Factor 23
NCT02237534	PHASE4	UNKNOWN	Lanthanum Versus Calcium Carbonate for Vascular Abnormalities in Patients With CKD and Hyperphosphatemia
NCT02322099	PHASE4	TERMINATED	Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss
NCT02836184	PHASE4	UNKNOWN	Nicotinic Acid in Hemodialysis Patients With Hyperphosphatemia
NCT03089216	PHASE4	COMPLETED	Combined Bleaching Technique: Efficacy and Tooth Sensitivity
NCT03425747	PHASE4	COMPLETED	Efficacy of Calcium Citrate Versus Calcium Carbonate for the Management of Chronic Hypoparathyroidism
NCT04479566	PHASE4	COMPLETED	Effect of Lithium Carbonate on Postoperative Sleep in Patients Undergoing Videoassisted Thoracic Surgery
NCT04609189	PHASE4	COMPLETED	Pearlium®/Effecti-Cal®, a Novel Formulation of Calcium, Vitamin D and Minerals for Prevention of Postmenopausal Bone Loss
NCT05313477	PHASE4	COMPLETED	The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF
NCT06042985	PHASE4	UNKNOWN	Comparison of the Absorption of Calcium Citrate and Calcium Carbonate in Patients With an RYGB, LSG, and OAGB
NCT06385093	PHASE4	UNKNOWN	A Study on the Prevention and Treatment of GIOP With Eldecalcitol
NCT00043069	PHASE3	COMPLETED	Calcium With or Without Estrogen and/or Risedronate in Preventing Osteoporosis in Patients With Prostate Cancer
NCT00054418	PHASE3	COMPLETED	Risedronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy for Primary Breast Cancer
NCT00153816	PHASE2/PHASE3	COMPLETED	Vitamin D/Calcium Polyp Prevention Study
NCT00352846	PHASE3	COMPLETED	Effect of Zoledronic Acid on Chemotherapy Induced Bone Loss
NCT00354302	PHASE3	COMPLETED	Bone Mineral Density in Postmenopausal Women With Primary Breast Cancer Who Are Receiving Treatment on Clinical Trial
NCT00529373	PHASE3	TERMINATED	A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018)
NCT00650637	PHASE3	TERMINATED	A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated Diarrhea
NCT01052051	PHASE2/PHASE3	COMPLETED	Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
NCT01072188	PHASE3	COMPLETED	Clinical Efficacy of 10% Arginine Bicarbonate Prophylaxis Paste
NCT01120600	PHASE3	COMPLETED	A Study to Assess Safety and Efficacy of Odanacatib (MK-0822) in Men With Osteoporosis (MK-0822-053)
NCT01190683	PHASE3	COMPLETED	Vitamin D and Muscle Strength and Surface (Electromyography) EMG
NCT01514851	PHASE3	COMPLETED	Phase III Double-blind Comparative Study of BAY77-1931 (Lanthanum Carbonate) With Calcium Carbonate
NCT01552122	PHASE3	WITHDRAWN	Efficacy and Safety of Odanacatib in Postmenopausal Women Previously Treated With Alendronate (MK-0822-050)
NCT01578200	PHASE3	COMPLETED	Outcome Study of Lanthanum Carbonate Compared With Calcium Carbonate in Hemodialysis Patients : Landmark Study
NCT02186600	PHASE3	COMPLETED	Heartland Osteoporosis Prevention Study
NCT02642484	PHASE3	UNKNOWN	Gabapentin in Treatment of Muscle Cramps in Patients With Liver Cirrhosis
NCT02642861	PHASE3	UNKNOWN	Cyclobenzaprine in Muscle Cramps With Liver Cirrhosis
NCT02642874	PHASE3	UNKNOWN	Methocarbamol in Treatment of Muscle Cramps in Cirrhotic Patients
NCT03634917	PHASE3	COMPLETED	Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence
NCT03792984	PHASE3	COMPLETED	The Effect of Calcium and Vitamin D Supplements on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients
NCT07056062	PHASE2/PHASE3	COMPLETED	Oral Calcium Supplementation in Labor
NCT06306131	PHASE2	RECRUITING	Phase II Study of Ovulation in Obese Women
NCT00000429	PHASE2	COMPLETED	Calcium Supplements for Bone Health in Juvenile Rheumatoid Arthritis
NCT00004488	PHASE2	COMPLETED	Phase II Randomized Study of Alendronate Sodium for Osteopenia in Patients With Gaucher’s Disease
NCT00061256	PHASE2	COMPLETED	The Effect of Alendronate, Calcium, and Vitamin D on Bone Mineral Density in HIV Infected Patients
NCT00073073	PHASE2	COMPLETED	Exemestane and Celecoxib in Postmenopausal Women at High Risk for Breast Cancer
NCT00074711	PHASE2	COMPLETED	Adding Phosphorus to Osteoporosis Drug Treatment
NCT00112437	PHASE2	COMPLETED	A Study to Examine the Effects of an Experimental Drug on Postmenopausal Osteoporosis (MK-0822-004)
NCT00416715	PHASE2	COMPLETED	Vitamin D Deficiency, Muscle Pain, Joint Pain, and Joint Stiffness in Postmenopausal Women Receiving Letrozole For Stage I-III Breast Cancer
NCT00560300	PHASE2	COMPLETED	Regulation of Bone Formation in Renal Osteodystrophy
NCT00620113	PHASE2	COMPLETED	Efficacy and Safety of Odanacatib (MK-0822) in Participants With Involutional Osteoporosis (MK-0822-022)
NCT00921557	PHASE2	COMPLETED	Safety and Effectiveness of Alendronate for Bone Mineral Density in HIV-infected Children and Adolescents
NCT00960934	PHASE2	TERMINATED	A Dose-Ranging Study of MK-5442 in Postmenopausal Women With Osteoporosis (MK-5442-001)
NCT00996801	PHASE2	COMPLETED	MK-5442 in the Treatment of Osteoporosis in Postmenopausal Women Previously Treated With an Oral Bisphosphonate (MK-5442-012)
NCT01037452	PHASE2	COMPLETED	Proof of Concept Study Efficacy of an Antacid/Lansoprazole Combination for Relief of Heartburn
NCT01403051	PHASE2	COMPLETED	High Dose Vitamin D and Calcium for Bone Health in Individuals Initiating HAART
NCT01493050	PHASE2	COMPLETED	The Effects of Sevelamer Carbonate on Diabetic Nephropathy
NCT01696279	PHASE2	COMPLETED	A Study to Assess the Pharmacokinetics of Lanthanum Carbonate, Investigate and Compare the Efficacy, Safety and Tolerability of Lanthanum Carbonate With Calcium Carbonate in Hyperphosphataemic Children and Adolescents With Chronic Kidney Disease on Dialysis
NCT01739855	PHASE2	COMPLETED	Bone Metabolism After Laparoscopic Gastric Bypass Surgery (BABS)
NCT01867697	PHASE2	COMPLETED	Nordic 8 - A Phase II Trial
NCT03113994	PHASE2	TERMINATED	Statin Monotherapy for Treatment of Endocrine Metabolic Disease Risk
NCT03198767	PHASE2	COMPLETED	Effects of Carbohydrate in Diet and Supplements on the Gastrointestinal Tolerability of LIK066
NCT03208582	PHASE2	COMPLETED	Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta?
NCT00732784	PHASE1	COMPLETED	Effect of Calcium on Gleevec Pharmacokinetics (PK) in Healthy Volunteers
NCT00732888	PHASE1	COMPLETED	Effect of Calcium on Tasigna Pharmacokinetics (PK) in Healthy Volunteers
NCT00967629	PHASE1	COMPLETED	Effect of Sevelamer Carbonate on Oxidative Stress in Patients With Diabetic Nephropathy
NCT01762995	PHASE1	COMPLETED	A Study to Evaluate the Effects of Calcium Carbonate and Ferrous Fumarate on Pharmacokinetics of Dolutegravir in Healthy Adult Subjects
NCT02473367	PHASE1	COMPLETED	The Effect of Antacids on the Pharmacokinetics (PK) of Raltegravir in Human Immunodeficiency Virus (HIV)-Infected Participants (MK-0518-824)
NCT02647671	PHASE1	COMPLETED	Aquamin and Prevention of Colon Cancer
NCT03612466	PHASE1	WITHDRAWN	A Dose Finding Study of CycloSam® Combined With External Beam Radiotherapy
NCT04914936	PHASE1	COMPLETED	A Study to Evaluate the One-way Interaction of Calcium Carbonate, Omeprazole, or Rifampin on ACP-196
NCT05109390	PHASE1	COMPLETED	A Study of the Drug Interactions Between Danicopan and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adults
NCT06650930	EARLY_PHASE1	NOT_YET_RECRUITING	Pharmacokinetics of Oral Calcium Carbonate in Parturients
NCT00263185	EARLY_PHASE1	COMPLETED	High Dose Vit D Musculoskeletal Symptoms & Bone Density in Anastrozole-Treated Breast Cancer With Marginal Vit D Status
NCT05571514	Not specified	RECRUITING	Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal Osteoporosis
NCT06352775	Not specified	ACTIVE_NOT_RECRUITING	Calcium Carbonate on Labor Induction
NCT00004489	Not specified	COMPLETED	Randomized Study of Alendronate in Adult Patients With Cystic Fibrosis Related Osteoporosis
NCT00302627	Not specified	COMPLETED	Pamidronate, Vitamin D, and Calcium for the Bone Disease of Kidney and Heart Transplantation
NCT00470353	Not specified	TERMINATED	Cholecalciferol and Calcium Carbonate in Treating Patients With Colon Cancer That Has Been Removed by Surgery
NCT00558623	Not specified	COMPLETED	Dietary Calcium Supplementation to Reduce Blood Lead in Pregnancy
NCT00686192	Not specified	COMPLETED	Calcium and Lipid Metabolism
NCT00710788	Not specified	COMPLETED	Reduce Cardiovascular Calcifications to Reduce QT Interval in Dialysis
NCT00837655	Not specified	WITHDRAWN	Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD)
NCT00982722	Not specified	COMPLETED	Vitamin D Supplementation After Parathyroid Surgery
NCT01040169	Not specified	COMPLETED	Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction
NCT01049815	Not specified	COMPLETED	Sevelamer Hydrochloride and Femoral and Carotid Intima Media Thickness Progression in End Stage Renal Disease
NCT01183910	Not specified	UNKNOWN	A Novel Oral Natural Extract for the Treatment of Senile Purpura
NCT01655810	Not specified	COMPLETED	Vitamin D, Cardiovascular Disease, and African Americans
NCT01735461	Not specified	UNKNOWN	Calcium Supplements Strategy for Kidney Stones Prevention in Crohn’s Patients
NCT01855009	Not specified	UNKNOWN	Study of Parental Ratings of Quality of Life and Body Composition in 5-19 Year Olds While Participating in the Good NEWS 4 Kids Program
NCT01928134	Not specified	COMPLETED	The Efficacy of Vitamin K2 n Human Osteoporosis, Blood-vessel Calcification and Sclerosis
NCT02474628	Not specified	COMPLETED	Consistencies in Responses to Sodium Bicarbonate?
NCT02731820	Not specified	COMPLETED	Efficacy of Potassium Citrate in the Treatment of Postmenopausal Osteopenia
NCT02830789	Not specified	COMPLETED	Investigation of the Optimal Calcium Supplement Following Roux-en-Y Gastric Bypass
NCT03286673	Not specified	COMPLETED	Comparison of Three Calcium Supplements
NCT03550534	Not specified	COMPLETED	The Effectiveness and Safety of Calcium Carbonate in Chronic Kidney Disease With Normophosphatemia
NCT03837886	Not specified	UNKNOWN	Effects of Sodium Bicarbonate Supplementation on Intermittent and Intense Task
NCT03869398	Not specified	COMPLETED	Does Preoperative Calcium and Calcitriol Decrease Rates of Post Thyroidectomy Hypocalcemia?
NCT03878667	Not specified	COMPLETED	Effects of Calcium Supplementation on Women in the Curves for Women Program
NCT04120922	Not specified	UNKNOWN	Assessing Bone Calcium Content in Children With Kidney Disease Treated With Two Different Medicines
NCT04146259	Not specified	COMPLETED	Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).