Cinnamon
drugOn this page
Also known as Ae-cinnamonB1472Ceylon cinnamonCeylon cinnamon barkCinnamomi ceylanici cortexCinnamomumCinnamomum s wholeCinnamomum verumCinnamomum verum barkCinnamomum verum inner barkCinnamomum verum powderCinnamomum verum stem barkCinnamomum verum wholeCinnamomum zeylanicum barkCinnamomum zeylanicum bark powderCinnamomum zeylanicum inner barkCinnamon (cinnamomum zeylanicum)Cinnamon barkCinnamon ceylon
Summary
Cinnamon (CHEMBL2108924) is a phase-3 clinical-stage unknown; indicated across 6 conditions including polycystic ovary syndrome and diabetes mellitus.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Unknown
- Indications: 6 conditions
- Clinical trials: 34
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL2108924 |
| Name | Cinnamon |
| Type | Unknown |
| Max phase | 3 |
Also known as: Ae-cinnamon, B1472, Ceylon cinnamon, Ceylon cinnamon bark, Cinnamomi ceylanici cortex, Cinnamomum, Cinnamomum s whole, Cinnamomum verum, Cinnamomum verum bark, Cinnamomum verum inner bark, Cinnamomum verum powder, Cinnamomum verum stem bark
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
6 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| polycystic ovary syndrome | 3 | MONDO:0008487 | EFO:0000660 |
| diabetes mellitus | 3 | MONDO:0005015 | EFO:0000400 |
| dental caries | 3 | MONDO:0005276 | EFO:0003819 |
| obesity disorder | 2 | MONDO:0011122 | EFO:0001073 |
| type 1 diabetes mellitus | 2 | MONDO:0005147 | MONDO:0005147 |
| type 2 diabetes mellitus | 2 | MONDO:0005148 | MONDO:0005148 |
Clinical trials
Total trials: 34.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 18 |
| PHASE3 | 4 |
| PHASE2 | 4 |
| PHASE2/PHASE3 | 2 |
| PHASE1 | 2 |
| EARLY_PHASE1 | 2 |
| PHASE4 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07518394 | PHASE4 | COMPLETED | Oral Essential Oils Efficacy in Acute Respiratory Symptoms |
| NCT00371800 | PHASE2/PHASE3 | COMPLETED | The Effect of Cinnamon on HbA1c Among Adolescents With Type I Diabetes |
| NCT00445354 | PHASE3 | COMPLETED | Randomized Controlled Clinical Trial of Cinnamon to Lower Hemoglobin A1c |
| NCT01483118 | PHASE3 | COMPLETED | Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS) |
| NCT03061916 | PHASE3 | UNKNOWN | Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus Mutans |
| NCT03610412 | PHASE3 | COMPLETED | Cinnamomum Cassia Effect on IGF1 and Metabolic Control in Patients With DM2 Without Glycemic Control Metformin Treated |
| NCT03711682 | PHASE2/PHASE3 | COMPLETED | Reducing Plasma Glucose Effect of Cinnamon in Type 2 Diabetic Patients in the Municipality of Comasagua |
| NCT00846898 | PHASE2 | COMPLETED | Is There a Metabolic Effect of Cinnamon on HbA1c, Blood Pressure and Serum Lipids in Type 2 Diabetes Mellitus? |
| NCT01847053 | PHASE1/PHASE2 | COMPLETED | Bioavailability Study of Cinnamon in Healthy Subjects |
| NCT02942056 | PHASE2 | WITHDRAWN | The Effect of Cinnamon Cassia on Diabetes Control and Cardiometabolic Risk Factors in Adults With Type 2 Diabetes Mellitus |
| NCT03219411 | PHASE2 | COMPLETED | Effects of Cinnamon Supplementation on Glucose Metabolism in Patients With Pre-diabetes |
| NCT04846231 | PHASE2 | COMPLETED | Supplements, Placebo, or Rosuvastatin Study |
| NCT00331279 | PHASE1 | COMPLETED | The Effect of Cinnamon Extract on Insulin Resistance Parameters in Polycystic Ovary Syndrome: A Pilot Study |
| NCT00970541 | PHASE1 | TERMINATED | Effect of Cinnamon Extract on Insulin Resistance in Polycystic Ovary Syndrome |
| NCT03946163 | EARLY_PHASE1 | COMPLETED | The Effect of Cinnamon on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome; a Pilot Study |
| NCT05157672 | EARLY_PHASE1 | UNKNOWN | Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon |
| NCT05685628 | Not specified | RECRUITING | Evaluation of the Quality of Life Induced by the Cinnamon Anti-odor Dressing in Patients With Malodorous Wounds |
| NCT06286735 | Not specified | ACTIVE_NOT_RECRUITING | Effects of Cinnamomum Supplementation in Chronic Kidney Disease Patients |
| NCT00951639 | Not specified | COMPLETED | Cassia Cinnamon for Glucose Uptake in Young Women |
| NCT01085019 | Not specified | COMPLETED | Impact of Spices and Herbs on Endothelial Function |
| NCT01350284 | Not specified | COMPLETED | The Effect of Natural Food Flavourings on Gastrointestinal and Cardiovascular Physiological Responses. |
| NCT02404701 | Not specified | COMPLETED | Effect of Over-the-counter Dietary Supplements on Kidney Stone Risk |
| NCT02422576 | Not specified | COMPLETED | Efficacy of Natural Ingredient to Improve the Swallowing Response of Patients With Oropharyngeal Dysphagia |
| NCT02455778 | Not specified | COMPLETED | Effect of Oral Cinnamon Intervention in Metabolic Syndrome |
| NCT03926442 | Not specified | COMPLETED | Spices, Inflammation and Vascular Response in Humans |
| NCT04023539 | Not specified | COMPLETED | Effect of Cinnamomum Zeylanicum on Glycemic Levels of Adult Patients With Type 2 Diabetes |
| NCT04259606 | Not specified | UNKNOWN | Effect of Cassia Cinnamon on Arterial Stiffness Parameters in Patients With Type 2 Diabetes Mellitus |
| NCT04342624 | Not specified | COMPLETED | Investigation of Cinnamon Spice on Glucose Tolerance in Subjects With Pre-diabetes |
| NCT04476160 | Not specified | COMPLETED | Effectiveness of Cinnamon on Insulin Resistance ( ECIRCCOS ) December 1, 2019 |
| NCT04686552 | Not specified | COMPLETED | Effect Cinnamon Spice on Postprandial Glucose and Insulin Responses |
| NCT06119555 | Not specified | UNKNOWN | Effect of Cinnamon Powder Capsules on Body Composition |
| NCT06199024 | Not specified | UNKNOWN | Cinnamon and COH in PCOS Women Underdoing IVF/ICSI Cycles |
| NCT06423248 | Not specified | COMPLETED | Culinary Spices in Metabolic Syndrome. |
| NCT06976255 | Not specified | COMPLETED | The Effect of Dark Chocolate and Cinnamon Sugars on Pain and Anxiety in University Students With Primary Dysmenorrhea |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: polycystic ovary syndrome, diabetes mellitus, dental caries