Cisatracurium

Summary

Cisatracurium (CHEMBL1201248) is an approved small-molecule nicotinic antagonist (ATC M03AC11).

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: M03AC11
• Clinical trials: 40
• Chemistry: 929.1 Da · C53H72N2O12+2

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1201248
Name	Cisatracurium
Type	Small molecule
Max phase	4
FDA approved	yes
PubChem CID	62887
ChEBI	CHEBI:140621
ATC	M03AC11
Molecular formula	C53H72N2O12+2
Molecular weight	929.1
InChIKey	YXSLJKQTIDHPOT-LJCJQEJUSA-N

SMILES: C[N@@+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N@+]4(CCC5=CC(=C(C=C5[C@H]4CC6=CC(=C(C=C6)OC)OC)OC)OC)C

IUPAC name: 5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate

ChEBI definition: A diester that is the (1R,1’R,2R,2’R)-diastereoisomer of atracurium, a quaternary ammonium ion consisting of pentane-1,5-diol with both hydroxy functions bearing 3-[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl groups. The active species in the skeletal muscle relaxant cisatracurium besylate.

Pharmacological roles (ChEBI): muscle relaxant, nicotinic antagonist.

Also known as: Cisatracurium, Cisatracurium cation, Cisatracurium ion, Nimbex, cisatracurium, CISATRACURIUM, ATRACURIUM BESYLATE

Parent form; salt/anhydrous children: CHEMBL1200641

Patent coverage: 24 distinct patent families (43 SureChEMBL compound mentions), from 2 matched compound structure(s). One matched structure accounts for 34 (79%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

0 indication records carry no mapped disease name (EFO/MeSH-only); none shown.

Clinical trials

Total trials: 40.

Phase distribution

Phase	Trials
Not specified	21
PHASE4	14
PHASE3	2
PHASE2	2
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07203287	PHASE4	RECRUITING	Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease
NCT00299650	PHASE4	COMPLETED	Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients
NCT01573715	PHASE4	UNKNOWN	Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS)
NCT01651572	PHASE4	COMPLETED	Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia
NCT01690338	PHASE4	UNKNOWN	A Study of Residual Curarization Incidence in China
NCT02111265	PHASE4	UNKNOWN	THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients
NCT02143362	PHASE4	UNKNOWN	Dexmedetomidine Combined With the Closed Loop of Target Controlled Infusion of Propofol for Anesthesia With Intraoperative Wake up
NCT02194855	PHASE4	COMPLETED	Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis
NCT02410590	PHASE4	WITHDRAWN	Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104)
NCT02483611	PHASE4	COMPLETED	Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block
NCT02503826	PHASE4	UNKNOWN	The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery
NCT02635542	PHASE4	COMPLETED	Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery
NCT03337373	PHASE4	COMPLETED	The Study of Pharmacokinetics and Pharmacodynamics of Cisatracurium
NCT07185074	PHASE4	COMPLETED	Intubation Conditions During ERCP With Lidocaine Aerosol Plus Low-dose Cisatracurium or Conventional-dose Cisatracurium
NCT02481193	PHASE3	COMPLETED	Effects of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia
NCT02502032	PHASE3	COMPLETED	Effects of Cisatracurium on Sccinylcholine-induced Fasciculations
NCT01273831	PHASE2	COMPLETED	Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia
NCT03904550	PHASE2	COMPLETED	Neuromuscular Blockade in Patients With Severe Renal Impairment
NCT05097508	EARLY_PHASE1	COMPLETED	Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia
NCT04524585	Not specified	RECRUITING	Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure
NCT06203405	Not specified	RECRUITING	The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
NCT06514209	Not specified	RECRUITING	Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome
NCT07143799	Not specified	RECRUITING	Scalp Block Versus General Anesthesia in Patients Undergoing Evacuation of Subdural Hematoma Via Burr Hole
NCT00912990	Not specified	TERMINATED	Pediatric Elective Intubation With and Without Muscle Relaxation Utilizing the Shikani Optical Stylet
NCT02033733	Not specified	UNKNOWN	When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier?
NCT02462915	Not specified	UNKNOWN	A Study Comparing the Supraglottic Airway Devices and Endotracheal Tube During Controlled Ventilation for Laparoscopic Surgery
NCT02546843	Not specified	COMPLETED	Depth of Neuromuscular Blockade and the Perioperative Conditions in Laparoscopic Surgery in Pediatric Population
NCT02588118	Not specified	COMPLETED	Gender and PK-PD of Propofol and Cisatracurium
NCT02840526	Not specified	COMPLETED	Thoracic Paravertebral Block in Pain Management After Renal Surgery
NCT02910206	Not specified	COMPLETED	Etomidate to Improve Outcome in Elderly Patients
NCT02914119	Not specified	COMPLETED	Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals
NCT03005860	Not specified	WITHDRAWN	Effect of TIVA Propofol vs Sevoflurane Anaesthetic on Serum Biomarkers and on PBMCs in Breast Cancer Surgery
NCT03112564	Not specified	COMPLETED	Endotracheal Intubation Without Muscle Relaxants
NCT03806374	Not specified	COMPLETED	Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?
NCT03831815	Not specified	COMPLETED	Evaluation of Residual Neuromuscular Blockade and of Late Recurarization in the Post Anesthesia Care Unit in Patients Undergoing Videolaparoscopic Cholecystectomy
NCT04921735	Not specified	COMPLETED	An Observational Study of Cisatracurium 0.15 mg/kg in Young and Elderly (≥ 80 Years) Patients.
NCT05241054	Not specified	UNKNOWN	Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation
NCT05310110	Not specified	COMPLETED	Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly
NCT05442905	Not specified	UNKNOWN	Quadratus Lumborum Versus Transversus Abdominis Plane Block Versus Caudal Block for Postoperative Analgesia After Pediatric Inguinal Hernia : Double-Blinded Randomized Trial
NCT05760976	Not specified	UNKNOWN	Median Effective Dose of Cisatracurium for the Prevention of Fasciculation Caused by the Injection of Succinylcholine

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).