Cocoa
drugOn this page
Also known as Cacao minar wholeCacao wholeChocolateTheobroma cacaoTheobroma cacao wholeTheobroma caribaea wholeTheobroma integerrima wholeTheobroma kalagua wholeTheobroma saltzmanniana whole
Summary
Cocoa (CHEMBL2108233) is a phase-3 clinical-stage unknown; indicated across 5 conditions including sleep disorder and peripheral arterial disease.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Unknown
- Indications: 5 conditions
- Clinical trials: 101
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL2108233 |
| Name | Cocoa |
| Type | Unknown |
| Max phase | 3 |
Also known as: Cacao minar whole, Cacao whole, Chocolate, Cocoa, Theobroma cacao, Theobroma cacao whole, Theobroma caribaea whole, Theobroma integerrima whole, Theobroma kalagua whole, Theobroma saltzmanniana whole, COCOA
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
5 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| sleep disorder | 3 | MONDO:0100081 | EFO:0008568 |
| peripheral arterial disease | 3 | MONDO:0005386 | EFO:0004265 |
| coronary artery disorder | 1 | MONDO:0005010 | EFO:0001645 |
| hypertensive disorder | 1 | MONDO:0005044 | EFO:0000537 |
1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 101.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 84 |
| PHASE4 | 5 |
| PHASE1 | 5 |
| PHASE1/PHASE2 | 3 |
| PHASE2 | 3 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01314924 | PHASE4 | COMPLETED | Effects of Acute Ingestion of Dark Chocolate on Endothelial Function in Hypertensive Patients |
| NCT02062710 | PHASE4 | COMPLETED | Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo |
| NCT02422745 | PHASE4 | COMPLETED | COcoa Supplement and Multivitamin Outcomes Study |
| NCT03205202 | PHASE4 | UNKNOWN | Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract |
| NCT05510375 | PHASE4 | UNKNOWN | Cocoa Supplementation, Inflammaging, and Epigenetic Aging |
| NCT04794530 | PHASE3 | RECRUITING | The COCOA-PAD II Trial |
| NCT00790465 | PHASE1/PHASE2 | UNKNOWN | Efficacy of Dark Chocolate in Achalasia Patients |
| NCT01064583 | PHASE1/PHASE2 | COMPLETED | Cocoa Flavanols and Painfree Walking Distance |
| NCT01412320 | PHASE1/PHASE2 | COMPLETED | Cocoa Flavanols in Renal Disease |
| NCT01431443 | PHASE2 | COMPLETED | Consumption of Chocolate in Pregnant Women. |
| NCT01444625 | PHASE2 | COMPLETED | Flavanols and Skin Photo Protection: a Clinical Trial |
| NCT01659060 | PHASE2 | COMPLETED | Chocolate Consumption in Healthy Pregnant Women Trial |
| NCT00421499 | PHASE1 | COMPLETED | Effects of Cocoa Intake on Blood Pressure in Elderly Individuals With Mild Hypertension |
| NCT00521573 | PHASE1 | COMPLETED | Effects of Chocolate on Coronary Vasomotion in Patients After Heart Transplantation |
| NCT00538083 | PHASE1 | COMPLETED | Cocoa and Endothelial Function in Adults With Elevated BMI |
| NCT00553774 | PHASE1 | COMPLETED | Effect of Cocoa Flavanols on Vascular Function |
| NCT00654862 | PHASE1 | COMPLETED | Acute Hemodynamic Effects of Cocoa Polyphenols in Subjects With Hypertension and Optimal Blood Pressure |
| NCT02924857 | Not specified | ACTIVE_NOT_RECRUITING | The Chocolate Touch Study |
| NCT05017051 | Not specified | RECRUITING | Study for the Quantification in Ecological Conditions of Sensorimotor and Dysexecutive Disorders in Cerebral Palsy Patients |
| NCT05232669 | Not specified | ACTIVE_NOT_RECRUITING | COcoa Supplement and Multivitamin Outcomes Study: Effects on Falls and Physical Performance |
| NCT05755217 | Not specified | RECRUITING | Renal Ultrasound Response After Chocolate Consumption |
| NCT06513052 | Not specified | ACTIVE_NOT_RECRUITING | Flavanol-rich Cocoa on Digestive and Cerebrovascular Health in the Colombian Adults |
| NCT06769035 | Not specified | ACTIVE_NOT_RECRUITING | Effect of a Food Supplement with Natural Extracts of Cocoa, Amaranth Seed and Ginger in Overweight or Obese Patients |
| NCT06808230 | Not specified | RECRUITING | Cocoa Extract for Migraine Trial |
| NCT06808282 | Not specified | ACTIVE_NOT_RECRUITING | Effects of Dark Chocolate on the Risk Factors of Cardiovascular Diseases |
| NCT07093346 | Not specified | RECRUITING | The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) |
| NCT07418151 | Not specified | RECRUITING | Effect of Maternal Chocolate Consumption on Fetal Non-Stress Test (NST) Reactivity. |
| NCT07556627 | Not specified | RECRUITING | Effect of Chocolate Consumption Prior to Prolonged Sitting on Cardiovascular Health in Adults |
| NCT00492713 | Not specified | COMPLETED | Polyphenol Bioavailability From Chocolate |
| NCT00493519 | Not specified | UNKNOWN | Cephalic Phase in Anorexia Nervosa,Bulimia Nervosa and Obese Binge Eaters |
| NCT00493740 | Not specified | UNKNOWN | Cephalic Phase of Oncology Patients Before and After Chemotherapy as Compared to Healthy Controls |
| NCT00513344 | Not specified | COMPLETED | Efficacy of Polyphenols From Milk and Dark Chocolate |
| NCT00639665 | Not specified | COMPLETED | Cocoa, Polyphenols, and the Kidney in Healthy Subjects and in Subjects With Hypertension and Diabetes Mellitus |
| NCT00825695 | Not specified | COMPLETED | Flavanol-Rich Cocoa and Cerebral Blood Flow |
| NCT00906763 | Not specified | UNKNOWN | Effects of Chocolate on Motor Symptoms of Parkinson’s Disease |
| NCT01099150 | Not specified | COMPLETED | Dark Chocolate and Platelet Function in Humans |
| NCT01259739 | Not specified | COMPLETED | Cocoa Flavanols and Exercise Capacity |
| NCT01344551 | Not specified | COMPLETED | Effects of Cocoa Flavanols on Human Cognitive Function |
| NCT01481389 | Not specified | COMPLETED | The Effect of Theobromine on Blood Lipid Parameters in Healthy Subjects |
| NCT01496235 | Not specified | TERMINATED | Effect of Cocoa Consumption in Cardiovascular and Immune Parameters |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: sleep disorder, peripheral arterial disease