Collagenase Clostridium Histolyticum

Summary

Collagenase Clostridium Histolyticum (CHEMBL2108709) is an approved enzyme (ATC M09AB02); indicated across 15 conditions including palmar fibromatosis and ulcer disease.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Enzyme
• ATC class: M09AB02 (+2 more)
• Indications: 15 conditions
• Clinical trials: 73

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL2108709
Name	Collagenase Clostridium Histolyticum
Type	Enzyme
Max phase	4
ATC	M09AB02, D03BA52, D03BA02

Also known as: AA-4500, AA4500, Clostridial collagenase, Clostridium histolyticum enzymes, Collagenase, Collagenase (clostridium histolyticum), Collagenase clostridium histolyticum, Cordase, Iruxol, MZ-004, Plaquase, Qwo

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

15 indications (7 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
palmar fibromatosis	4	MONDO:0006345	EFO:0004229
ulcer disease	4	MONDO:0043839	MONDO:0043839
decubitus ulcer	3	MONDO:0004646	EFO:0007067
lipoma	2	MONDO:0005106	EFO:0000759
frozen shoulder	2	MONDO:0006763	EFO:1000941
urethral stricture	2	MONDO:0002127	HP:0012227
disease of the tendon	1	MONDO:0100010	EFO:1001434

8 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 73.

Phase distribution

Phase	Trials
PHASE4	18
PHASE3	17
PHASE2	16
Not specified	13
PHASE1	6
PHASE2/PHASE3	1
PHASE1/PHASE2	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03406338	PHASE4	ACTIVE_NOT_RECRUITING	Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease
NCT06649539	PHASE4	RECRUITING	Delayed Dose Collagenase Clostridium Histolyticum (CCH) Protocol for Men With Peyronie’s Disease
NCT00651820	PHASE4	COMPLETED	Effect of Collagenase on Healing and Scarring
NCT01056198	PHASE4	COMPLETED	Santyl vs. Sharp Debridement of Diabetic Foot Wounds
NCT01143714	PHASE4	COMPLETED	A Study to Look at the Effects of Four Weeks of Treatment on the Healing of Diabetic Foot Ulcers
NCT01143727	PHASE4	COMPLETED	Enzymatic Versus (vs) Autolytic Debridement of Diabetic Foot Ulcers
NCT01408277	PHASE4	COMPLETED	Using Santyl on Diabetic Foot Ulcers
NCT01450397	PHASE4	COMPLETED	MRI Results in Dupuytren’s Contracture Before and After Injection With Xiaflex
NCT01498640	PHASE4	COMPLETED	Retreatment of Recurrent Dupuytren’s Contractures
NCT01516463	PHASE4	WITHDRAWN	Using Santyl or Bacitracin on Second Degree Burns
NCT02476461	PHASE4	UNKNOWN	Prospective Randomized Trial Between Needle Fasciotomy and Xiapex for Dupuytrens Contracture
NCT02581488	PHASE4	COMPLETED	Use of Santyl in Diabetic Foot Ulcers
NCT02647619	PHASE4	COMPLETED	Dupuytren´s Disease Study. Primary Disease, MCP Joint, Xiapex, PNF
NCT02673229	PHASE4	TERMINATED	Comparison of Collagenase With Antibiotic Ointment of Minor Partial Thickness Burns
NCT02716519	PHASE4	WITHDRAWN	Use of Santyl Within an Accountable Care Organization
NCT02718625	PHASE4	TERMINATED	Study of SANTYL® vs Hydrogel (SoloSite®) for Pressure Ulcers
NCT03000114	PHASE4	UNKNOWN	Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren’s Disease
NCT05026216	PHASE4	COMPLETED	To Assess the Effectiveness of Multiple Dose, Multiple Concentrations of Qwo, for the Treatment of Mild to Moderate Cellulite.
NCT00014742	PHASE3	COMPLETED	Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren’s Disease
NCT00260429	PHASE3	COMPLETED	Collagenase in the Treatment of Dupuytrens Disease
NCT00528424	PHASE3	COMPLETED	AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren’s Disease
NCT00528606	PHASE3	COMPLETED	AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren’s Contracture
NCT00528840	PHASE3	COMPLETED	Safety and Efficacy Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren’s Disease
NCT00533273	PHASE3	COMPLETED	Non-US Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren’s Disease
NCT00701974	PHASE2/PHASE3	SUSPENDED	Non-inferiority Clinic of Kollagenase® Compared Iruxol® in Treatment of Cutaneous Ulcers
NCT01221597	PHASE3	COMPLETED	Study of AA4500 in the Treatment of Peyronie’s Disease
NCT01221623	PHASE3	COMPLETED	Study of AA4500 in the Treatment of Peyronie’s Disease
NCT01229436	PHASE3	COMPLETED	Treatment Of Dupuytren’s Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex)
NCT01243411	PHASE3	COMPLETED	A Study of AA4500 in Men With Peyronie’s Disease
NCT01588353	PHASE3	COMPLETED	Collagenase Option for Reduction of Dupuytren’s Contracture in Japan
NCT01674634	PHASE3	COMPLETED	Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects With Multiple Dupuytren’s Contractures
NCT01685437	PHASE3	COMPLETED	A Phase 3, Open-label Study of the Safety and Effectiveness of AA4500 Administered Twice Per Treatment Cycle for up to Four Treatment Cycles (2 x 4) in Men With Peyronie’s Disease
NCT02004626	PHASE3	WITHDRAWN	Evaluate the Noninferiority of Medicines Treating Uninfected Pressure Ulcers.
NCT02267460	PHASE3	COMPLETED	An Open-label Study to Assess the Safety and Effectiveness of AA4500 in Combination With the ErecAid® Esteem® Manual Vacuum Therapy System in Treating Men With Peyronie’s Disease
NCT02725528	PHASE3	COMPLETED	Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren’s
NCT04874870	PHASE3	COMPLETED	Effectiveness of Splinting After Collagenase Injection
NCT00004409	PHASE2	COMPLETED	Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren’s Disease
NCT00261144	PHASE2	UNKNOWN	Collagenase in the Treatment of Cellulite
NCT00261196	PHASE2	WITHDRAWN	Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder)
NCT00261209	PHASE1/PHASE2	COMPLETED	Collagenase in the Treatment of Zone II Flexor Tendon Adhesions in the Hand

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).