Desflurane

Summary

Desflurane (CHEMBL1200733) is an approved small-molecule inhalation anaesthetic (ATC N01AB07); indicated across 2 conditions including kidney failure.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: N01AB07
• Indications: 2 conditions
• Clinical trials: 152
• Chemistry: 168.04 Da · C3H2F6O

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1200733
Name	Desflurane
Type	Small molecule
Max phase	4
FDA approved	yes
PubChem CID	42113
ChEBI	CHEBI:4445
ATC	N01AB07
Molecular formula	C3H2F6O
Molecular weight	168.04
InChIKey	DPYMFVXJLLWWEU-UHFFFAOYSA-N

SMILES: C(C(F)(F)F)(OC(F)F)F

IUPAC name: 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane

Pharmacological roles (ChEBI): inhalation anaesthetic.

Also known as: Desflurane, Desflurano, I-653, Suprane, DESFLURANE, desflurane, [18F]-Desflurane

Patent coverage: 1,810 distinct patent families (5,818 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

2 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
kidney failure	2	MONDO:0001106	EFO:1002048

1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 152.

Phase distribution

Phase	Trials
Not specified	89
PHASE4	47
PHASE3	8
PHASE2	4
PHASE1/PHASE2	2
PHASE2/PHASE3	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05990790	PHASE4	RECRUITING	The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
NCT06779890	PHASE4	RECRUITING	Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome
NCT07123870	PHASE4	RECRUITING	Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.
NCT00244517	PHASE4	TERMINATED	DIAFAX I+II-Effects of Inhalative Anesthetics on Left Ventricular Diastolic Function
NCT00446212	PHASE4	COMPLETED	Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
NCT01125982	PHASE4	COMPLETED	Postoperative Fatigue and Nausea Related to Choice of Anaesthetic Regimens
NCT01132157	PHASE4	COMPLETED	Comparison of the Protective Effect of Desflurane and Propofol in Patients With Renal Transplantation
NCT01167803	PHASE4	COMPLETED	Anesthesia for Obese Patients: Desflurane Versus Xenon
NCT01199237	PHASE4	COMPLETED	Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
NCT01270620	PHASE4	COMPLETED	Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement
NCT01310582	PHASE4	COMPLETED	Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females
NCT01452256	PHASE4	COMPLETED	Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery
NCT01486953	PHASE4	UNKNOWN	Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum
NCT01833676	PHASE4	COMPLETED	To Compare Effect of Sevoflurane Versus Desflurane on the Return of Swallowing Reflexes in the Elderly
NCT01878656	PHASE4	COMPLETED	Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery
NCT01886664	PHASE4	COMPLETED	Comparison of PRS According to Inhalation Agent During LDLT
NCT01924871	PHASE4	COMPLETED	Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia
NCT01985854	PHASE4	UNKNOWN	Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery
NCT02019797	PHASE4	UNKNOWN	Desflurane-induced Myocardial Protection
NCT02048475	PHASE4	WITHDRAWN	Electroencephalogram During Desflurane Anaesthesia
NCT02105610	PHASE4	COMPLETED	Volatile Anesthetics to Reduce Mortality in Cardiac Surgery
NCT02149628	PHASE4	COMPLETED	The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide
NCT02174575	PHASE4	WITHDRAWN	Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery
NCT02213718	PHASE4	UNKNOWN	The Effect of Desflurane on Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting
NCT02335151	PHASE4	COMPLETED	CTC Pancreatic Adenocarcinoma
NCT02379546	PHASE4	COMPLETED	The Effect of Anaesthesia Depth on Oculo-cardiac Reflex
NCT02379715	PHASE4	COMPLETED	Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane
NCT02631525	PHASE4	COMPLETED	Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index.
NCT02717780	PHASE4	COMPLETED	Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome
NCT02834845	PHASE4	COMPLETED	Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension
NCT02925611	PHASE4	COMPLETED	Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery
NCT02987218	PHASE4	COMPLETED	Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery
NCT03006250	PHASE4	UNKNOWN	The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia
NCT03099616	PHASE4	COMPLETED	Automated Closed Loop Propofol Anaesthesia Versus Desflurane Inhalation Anaesthesia In Bariatric Surgery
NCT03194074	PHASE4	UNKNOWN	Early Cognitive Function in Elderly Patients After Laser Laryngeal Surgery: Des vs Prop
NCT03209193	PHASE4	COMPLETED	Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
NCT03435003	PHASE4	COMPLETED	Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy
NCT03504033	PHASE4	WITHDRAWN	Xenon-anesthesia on Patients Undergoing Major Liver-resection
NCT03540030	PHASE4	COMPLETED	Opioid-Free Shoulder Arthroplasty
NCT03917186	PHASE4	COMPLETED	Desflurane vs. Sevoflurane in Endovascular Aortic Repair

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

PharmGKB dosing guidelines (1) — CPIC / DPWG genotype-guided dosing for this drug (drug × pharmacogene):

Guideline	Source	Gene(s)	Dosing	Recommendation
Annotation of CPIC Guideline for desflurane, enflurane, halothane, iso	CPIC	CACNA1S;RYR1		yes

PharmGKB also curates 47 clinical and 18 variant annotation(s) for this drug (gene-keyed; see PharmGKB).

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).