Dexketoprofen

Summary

Dexketoprofen (CHEMBL75435) is an approved small-molecule non-steroidal anti-inflammatory drug (ATC M01AE17); indicated across 6 conditions including rheumatic disorder and injury.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: M01AE17 (+1 more)
• Indications: 6 conditions
• Clinical trials: 49
• Chemistry: 254.28 Da · C16H14O3

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL75435
Name	Dexketoprofen
Type	Small molecule
Max phase	4
FDA approved	no
PubChem CID	667550
ChEBI	CHEBI:76128
ATC	M01AE17, M02AA27
Molecular formula	C16H14O3
Molecular weight	254.28
InChIKey	DKYWVDODHFEZIM-NSHDSACASA-N

SMILES: C[C@@H](C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O

IUPAC name: (2S)-2-(3-benzoylphenyl)propanoic acid

ChEBI definition: A monocarboxylic acid that is (S)-hydratropic acid substituted at position 3 on the phenyl ring by a benzoyl group. A cyclooxygenase inhibitor, it is used to relieve short-term pain, such as muscular pain, dental pain and dysmenorrhoea.

Pharmacological roles (ChEBI): non-steroidal anti-inflammatory drug, cyclooxygenase 1 inhibitor, cyclooxygenase 2 inhibitor, non-narcotic analgesic.

Also known as: (s)-ketoprofen, Arveles, Dexketoprofen, Dexketoprofene, Dexketoprofeno, Keral, Ketoprofen, (s)-, SID26754382, SID26754383, SID56320640, DEXKETOPROFEN, dexketoprofen

Patent coverage: 1,462 distinct patent families (5,327 SureChEMBL compound mentions), from 2 matched compound structure(s). One matched structure accounts for 5,288 (99%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

Broader ChEMBL bioactivity targets: 9 (assay-derived). Sample: Microtubule-associated protein tau, Nuclear receptor ROR-gamma, Survival motor neuron protein, Fructose-bisphosphate aldolase, ATP-dependent DNA helicase Q1, Beta-lactamase, Interleukin-8 receptors, CXCR1/CXCR2, Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2.

Bioactivity

ChEMBL activities: 7 potent at pChembl ≥ 5 of 14 total. Top 100 by potency (10 = 0.1 nM, 6 = 1 µM):

Target	pChembl	Type	Value	Unit	Activity ID
PTGS1	8.72	IC50	1.9	nM	CHEMBL_ACT_195657
PTGS1	8.43	AC50	3.7	nM	CHEMBL_ACT_25205123
PTGS1	8.35	IC50	4.48	nM	CHEMBL_ACT_7689650
PTGS2	7.57	IC50	27	nM	CHEMBL_ACT_195656
PTGS1	7.57	AC50	26.7	nM	CHEMBL_ACT_25206056
CXCR1	7.3	IC50	50	nM	CHEMBL_ACT_1492263
PTGS2	6.64	IC50	230	nM	CHEMBL_ACT_7689652

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

1 approved indication. FDA phase 4, plus an anticancer drug’s labelled cancer uses (which ChEMBL often logs at phase 3).

Indication	Phase	MONDO	EFO
rheumatic disorder	4	MONDO:0005554	EFO:0005755

1 disease in clinical trials (phase 1–3, investigational — not approved indications). Highest ChEMBL trial phase per disease; a non-cancer approved use is occasionally logged at phase 3 here.

Disease (in trials)	Phase	MONDO	EFO
injury	3	MONDO:0021178	EFO:0000546

4 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 49.

Phase distribution

Phase	Trials
PHASE4	24
Not specified	13
PHASE3	6
PHASE2	3
PHASE2/PHASE3	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07176572	PHASE4	NOT_YET_RECRUITING	Analgesic Efficacy of Transcutaneous Electrical Nerve Stimulation and Dexketoprofen in Renal Colic
NCT01422291	PHASE4	COMPLETED	IV Paracetamol, Dexketoprofen or Morphine for the Treatment of Low Back Pain
NCT01558622	PHASE4	UNKNOWN	Intraoperative Use of Dexketoprofen Trometamol, Pethidine Hcl, Tramadol Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication
NCT01730326	PHASE4	COMPLETED	Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack
NCT02018601	PHASE4	UNKNOWN	Intercostal Nerves Block in the Midaxillary Line Versus Paravertebral Block for no Reconstructive Breast Surgery
NCT02086097	PHASE4	COMPLETED	Dexketoprofen Trometamol in Postoperative Endodontic Pain
NCT02092012	PHASE4	UNKNOWN	Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on Abdominal Hysterectomy Patients
NCT02159547	PHASE4	COMPLETED	IV Dexketoprofen vs Placebo in Migranie Attack
NCT02160236	PHASE4	UNKNOWN	Comparison of Postoperative Analgesic Efficacy of Intravenous Dexketoprofen Trometamol With Tenoxicam
NCT02285972	PHASE4	COMPLETED	Efficacy of Intravenous Dexketoprofen and Tenoxicam on Propofol Associated Injection Pain
NCT02373514	PHASE4	UNKNOWN	IV Paracetamol Versus IV Dexketoprofen in Dysmenorrhea
NCT02380001	PHASE4	COMPLETED	Analgesic Preoperative/Postoperative Dexketoprofen Trometamol in Third Molar Surgery
NCT02568735	PHASE4	COMPLETED	Dexketoprofen and Etoricoxib in Patients Undergoing Hip Arthroplasty
NCT02929147	PHASE4	UNKNOWN	Comparison of Efficacy and Safety of the Postoperative Analgesia Methods
NCT03107338	PHASE4	COMPLETED	Preventive Treatment of Pain After Dental Implant Surgery
NCT03122314	PHASE4	COMPLETED	Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Nontraumatic Musculoskeletal Pain
NCT03428503	PHASE4	COMPLETED	Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Traumatic Musculoskeletal Pain
NCT03768882	PHASE4	COMPLETED	Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Sore Throat
NCT04200885	PHASE4	COMPLETED	Is Therapeutic Elastic Bandage As Effective As Corticosteroids Following Third Molar Surgery?
NCT04372264	PHASE4	UNKNOWN	Intravenous Paracetamol, Dexketoprofen and Ibuprofen in the Treatment of Acute Migraine Attack Headache
NCT04533568	PHASE4	COMPLETED	Ibuprofen in Migraine Patients
NCT04609254	PHASE4	COMPLETED	Paracetamol, Dexketoprofen and Ibuprofen In Non-Traumatic Acute Low Back Pain
NCT06060236	PHASE4	UNKNOWN	Dexketoprofen and Ibuprofen in Long Bone Fractures
NCT06558916	PHASE4	COMPLETED	Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic
NCT06404177	PHASE3	RECRUITING	Enantyum® IV Versus Piroxen® IM in Emergency Pain Management
NCT01902134	PHASE3	COMPLETED	Oral Treatment for Orthopaedic Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride
NCT01904149	PHASE3	COMPLETED	Oral Treatment for Gynaecological Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride
NCT02602197	PHASE3	UNKNOWN	Intravenous Paracetamol Compared Dexketoprofen for Postoperative Analgesia After Septoplasty
NCT03585036	PHASE3	UNKNOWN	Oral Tramadol Versus Oral Dexketoprofen for Reducing Pain During Office Hysteroscopy
NCT05001555	PHASE3	COMPLETED	Efficacy and Safety of Dexketoprofen/Vitamin B Vs Dexketoprofen for Post-traumatic Cervical Sprain Grade I-II
NCT07057752	PHASE2/PHASE3	COMPLETED	Virtual Reality for Pain and Anxiety Relief During Peripheral Angioplasty
NCT07098962	PHASE2/PHASE3	COMPLETED	KinesioTaping for Thoracic Drain Support
NCT01307020	PHASE2	COMPLETED	Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain
NCT04161690	PHASE2	UNKNOWN	Evaluation of Dexketoprofen in Total Knee Arthroplasty
NCT04178109	PHASE2	COMPLETED	Oral Use of Dexketoprofen/Tramadol for Acute Postoperative Pain in Total Hip Replacement With a Direct Anterior Approach.
NCT05027126	PHASE1	COMPLETED	Comparison of Bioavailability of Dexketoprofen-Vit B vs Dexketoprofen, in Healthy Subjects, Under Fasting Conditions
NCT07248540	Not specified	RECRUITING	IV Magnesium in the Treatment of Acute Dysmenorrhea
NCT01947205	Not specified	COMPLETED	Pain and Suction Curettage
NCT03170713	Not specified	UNKNOWN	Impact of Preemptive Intravenous Ibuprofen on Postoperative Edema and Trismus in the Third Molar Teeth
NCT03170726	Not specified	UNKNOWN	Impact of Preemptive Intravenous Ibuprofen on Intraoperative Analgesia in Third Molar Teeth
NCT03420911	Not specified	COMPLETED	Determination of the Effects of Change in Anxiety Level on Pain Perception in Patients Who Present to Emergency Department
NCT03697746	Not specified	UNKNOWN	Comparison of Dexketoprofen, Paracetamol and Ibuprofen in the Treatment of Primary Dysmenorrhea
NCT04213287	Not specified	UNKNOWN	Multimodal Analgesia Methods in Patients Undergoing IPACK Block in Knee Arthroplasty
NCT04227912	Not specified	COMPLETED	Transversus Abdominis Plane(TAP) Block, Local Infiltration and Intravenous Dexketoprofen in Inguinal Hernia Repair
NCT04252521	Not specified	COMPLETED	Intravenous Metoclopramide Versus Dexketoprofen Trometamol Versus Metoclopramide+ Dexketoprofen Trometamol in Migraine
NCT04847024	Not specified	COMPLETED	Parecoxib vs. Dexketoprofen for the Management of Pain After Cesarean Section.
NCT05125796	Not specified	COMPLETED	Analgesic Use for Pain Relief in Scorpion Sting
NCT05176158	Not specified	COMPLETED	Dexketoprofen Dosage According to Chronotherapy
NCT07386288	Not specified	COMPLETED	Short-term Perfusion Effects: Dexketoprofen/Tramadol

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No CPIC/DPWG dosing guideline or drug-level clinical/variant annotations in PharmGKB for this molecule.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).