Enbucrilate

Summary

Enbucrilate (CHEMBL2104251) is a phase-3 clinical-stage small molecule; indicated across 2 conditions including esophageal varices and atopic eczema.

At a glance

• Status: Max clinical phase 3 (not approved)
• Modality: Small molecule
• Indications: 2 conditions
• Clinical trials: 8
• Chemistry: 153.18 Da · C8H11NO2

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL2104251
Name	Enbucrilate
Type	Small molecule
Max phase	3
FDA approved	no
PubChem CID	23087
Molecular formula	C8H11NO2
Molecular weight	153.18
InChIKey	JJJFUHOGVZWXNQ-UHFFFAOYSA-N

SMILES: CCCCOC(=O)C(=C)C#N

IUPAC name: butyl 2-cyanoprop-2-enoate

Also known as: Enbucrilate, Enbucrilato, Glustitch, Histoacryl, Indermil, Medibond, Medicryl, N-butyl cyanoacrylate, Periacryl, Vetbond, ENBUCRILATE

Patent coverage: 2,294 distinct patent families (5,773 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

2 diseases in clinical trials (phase 1–3, investigational — not approved indications). Highest ChEMBL trial phase per disease; a non-cancer approved use is occasionally logged at phase 3 here.

Disease (in trials)	Phase	MONDO	EFO
esophageal varices	3	MONDO:0001221	EFO:0009545
atopic eczema	3	MONDO:0004980	EFO:0000274

Clinical trials

Total trials: 8.

Phase distribution

Phase	Trials
Not specified	6
PHASE3	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01717612	PHASE3	UNKNOWN	A Prospective, Randomized Trial of Histoacryl Injection Versus Thrombin in the Control of Acute Gastric Variceal Bleeding
NCT03388125	PHASE3	UNKNOWN	Endoscopic Injection Sclerotherapy Versus N-butyl-2-cyanoacrylate Injection
NCT07221695	Not specified	ENROLLING_BY_INVITATION	Embolization Strategies for Pelvic Venous Disorders: Foam + Glue vs Foam + Coils
NCT01592942	Not specified	UNKNOWN	Mesh Fixation in Lichtenstein Hernioplasty
NCT02468167	Not specified	UNKNOWN	Acute Gastric Variceal Bleeding: Endoscopic Treatment Versus BRTO
NCT02468180	Not specified	UNKNOWN	Primary Prophylaxis of Gastric Variceal Bleed
NCT02468206	Not specified	COMPLETED	Secondary Prophylaxis of Gastric Variceal Bleed
NCT02935426	Not specified	UNKNOWN	Comparison of Cyanoacrylate Adhesives to Sutures in the Palate After Connective Tissue Graft

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).