Enflurane

Summary

Enflurane (CHEMBL1257) is an approved small-molecule anaesthetic (ATC N01AB04).

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: N01AB04
• Clinical trials: 1
• Chemistry: 184.49 Da · C3H2ClF5O

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1257
Name	Enflurane
Type	Small molecule
Max phase	4
FDA approved	no
PubChem CID	3226
ChEBI	CHEBI:4792
ATC	N01AB04
Molecular formula	C3H2ClF5O
Molecular weight	184.49
InChIKey	JPGQOUSTVILISH-UHFFFAOYSA-N

SMILES: C(C(OC(F)F)(F)F)(F)Cl

IUPAC name: 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane

ChEBI definition: An ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups.

Pharmacological roles (ChEBI): anaesthetic.

Also known as: Alyrane, ANESTHETIC COMPOUND NO. 347, Compound 347, Efrane, Enflurane, Enflurano, Ethrane, Methylflurether, NSC-115944, Ohio 347, R-E-235CA2, ENFLURANE

Patent coverage: 1,954 distinct patent families (6,124 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

0 indication records carry no mapped disease name (EFO/MeSH-only); none shown.

Clinical trials

Total trials: 1.

Phase distribution

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00815269	Not specified	COMPLETED	Vasodilation Effect of Inhalational Anesthetics

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

PharmGKB dosing guidelines (1) — CPIC / DPWG genotype-guided dosing for this drug (drug × pharmacogene):

Guideline	Source	Gene(s)	Dosing	Recommendation
Annotation of CPIC Guideline for desflurane, enflurane, halothane, iso	CPIC	CACNA1S;RYR1		yes

PharmGKB also curates 47 clinical and 14 variant annotation(s) for this drug (gene-keyed; see PharmGKB).

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).