Ethyl Chloride

Summary

Ethyl Chloride (CHEMBL46058) is an approved small-molecule inhalation anaesthetic (ATC N01BX01); indicated across 1 condition.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: N01BX01
• Indications: 1 condition
• Clinical trials: 10
• Chemistry: 64.51 Da · C2H5Cl

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL46058
Name	Ethyl Chloride
Type	Small molecule
Max phase	4
FDA approved	no
PubChem CID	6337
ChEBI	CHEBI:47554
ATC	N01BX01
Molecular formula	C2H5Cl
Molecular weight	64.51
InChIKey	HRYZWHHZPQKTII-UHFFFAOYSA-N

SMILES: CCCl

IUPAC name: chloroethane

ChEBI definition: The simplest and least toxic member of the class of chloroethanes, that is ethane in which a single hydrogen is substituted by a chlorine. A colourless gas at room temperature and pressure (boiling point 12°C), it is used as a mild topical anaesthetic to numb the skin prior to ear piercing, skin biopsies, etc., and is also used in the treatment of sports injuries. It was formerly used in the production of tetraethyllead.

Pharmacological roles (ChEBI): inhalation anaesthetic, local anaesthetic, antipruritic drug.

Also known as: Ethyl chloride, Gebauer’s ethyl chloride, Chloro-ethane, chloroethane, Ethylchloride, ETHYL CHLORIDE

Patent coverage: 23,537 distinct patent families (58,134 SureChEMBL compound mentions), from 2 matched compound structure(s). One matched structure accounts for 57,977 (100%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

1 indication record carries no mapped disease name (EFO/MeSH-only); none shown.

Clinical trials

Total trials: 10.

Phase distribution

Phase	Trials
Not specified	6
PHASE4	4

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01576770	PHASE4	UNKNOWN	In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?
NCT02592629	PHASE4	TERMINATED	The Efficacy of Local Anesthetics to Reduce Shoulder Pain Post-Steroid Injections
NCT04207710	PHASE4	COMPLETED	Safety of Gebauer’s Pain Ease and Gebauer’s Ethyl Chloride
NCT04635696	PHASE4	COMPLETED	Ethyl Chloride for NPWT
NCT06651788	Not specified	RECRUITING	Does Ethyl Chloride Spray Work?
NCT02587143	Not specified	COMPLETED	Ethyl Chloride Vapocoolant as Anesthesia for Arterial Punctures
NCT05306470	Not specified	COMPLETED	Ethyl Chloride Versus 5% Lidocaine for Topical Anesthesia of Oral Mucosa
NCT05568563	Not specified	COMPLETED	Comparison of Effectiveness of Pre-cooling With Ethyl Chloride Versus Honey
NCT06274905	Not specified	COMPLETED	Topical Anaesthesia in Cutaneous Head and Neck Surgery
NCT06596486	Not specified	COMPLETED	A Comparison of CoolStick With Ethyl Chloride for the Assessment of Light Touch

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).