Fibrin
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Also known as Factor 1aFibrinaFibrineHuman fibrin
Summary
Fibrin (CHEMBL2108390) is a phase-3 clinical-stage unknown; indicated across 24 conditions including thyroid gland carcinoma and injury.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Unknown
- Indications: 24 conditions
- Clinical trials: 43
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL2108390 |
| Name | Fibrin |
| Type | Unknown |
| Max phase | 3 |
Also known as: Factor 1a, Fibrin, Fibrina, Fibrine, Human fibrin, FIBRIN
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
24 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| thyroid gland carcinoma | 3 | MONDO:0015075 | EFO:0002892 |
| injury | 3 | MONDO:0021178 | EFO:0000546 |
| pterygium | 3 | MONDO:0005085 | EFO:0000678 |
| peripheral vascular disease | 3 | MONDO:0005294 | EFO:0003875 |
| anus disorder | 3 | MONDO:0002519 | EFO:0009660 |
| arthropathy | 3 | MONDO:0006816 | HP:0003040 |
| breast neoplasm | 3 | MONDO:0021100 | MONDO:0007254 |
| endometrium neoplasm | 3 | MONDO:0021251 | MONDO:0011962 |
| lymphedema | 3 | MONDO:0019297 | MONDO:0019297 |
| Crohn disease | 3 | MONDO:0005011 | EFO:0000384 |
| periodontitis | 2 | MONDO:0005076 | EFO:0000649 |
| epicondylitis | 2 | MONDO:0001875 | EFO:1001896 |
| rotator cuff syndrome | 2 | MONDO:0007028 | EFO:1001250 |
| burn | 1 | MONDO:0043519 | EFO:0009516 |
10 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 43.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 24 |
| PHASE3 | 9 |
| PHASE4 | 5 |
| PHASE2 | 2 |
| PHASE1 | 2 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01022164 | PHASE4 | TERMINATED | Use of Fibrin Glue in Vitreoretinalsurgery |
| NCT01306851 | PHASE4 | UNKNOWN | Prevention of Anastomotic Leak in Gastrointestinal (GI) Anastomosis With the Application of Tisseal in the Anastomotic Line |
| NCT01472913 | PHASE4 | COMPLETED | Fibrin Sealant in Bilateral Simultaneous Total Knee Arthroplasty With Focus on Blood Loss, Pain, Swelling and Strength |
| NCT01538927 | PHASE4 | COMPLETED | Effect of Fibrin Sealant on Early Wound Healing |
| NCT07455591 | PHASE4 | COMPLETED | A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement |
| NCT00028951 | PHASE3 | COMPLETED | Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva |
| NCT00161915 | PHASE3 | COMPLETED | Efficacy and Safety of Endoscopic Injection of Fibrin Sealant Versus Endoscopic Ligature for Bleeding Esophageal Varices |
| NCT00475410 | PHASE3 | COMPLETED | Efficacy and Safety of Adipose Stem Cells to Treat Complex Perianal Fistulas Not Associated to Crohn´s Disease |
| NCT01306370 | PHASE3 | COMPLETED | Fibrin Glue or Tranexamic Acid for Total Knee Arthroplasty |
| NCT01631448 | PHASE3 | COMPLETED | Fibrin Based Adhesive for the Prevention of Surgical Complications in the Kidney Transplantation |
| NCT01803347 | PHASE3 | COMPLETED | Clinical Trial to Evaluate the Efficacy and Safety of Stem Cells |
| NCT02120651 | PHASE3 | COMPLETED | Fibrin Monomer Compared With Hemostatic Sponge in the Integrity of the Graft During Tympanoplasty |
| NCT02150720 | PHASE3 | COMPLETED | Prevention of Postoperative Bleeding in Subcapital Femoral Fractures |
| NCT02153593 | PHASE3 | TERMINATED | Postoperative Bleeding Prevention in Massive Bone Tumour Resection |
| NCT04621799 | PHASE2/PHASE3 | UNKNOWN | Fibrin for Chronic Multi-level Discogenic Low Back Pain |
| NCT02343263 | PHASE2 | TERMINATED | Effect of Bupivacaine-infused Fibrin Sealant Application on Post-tonsillectomy Pain & Hemorrhage |
| NCT03449082 | PHASE2 | COMPLETED | Treatment of Intractable Common Extensor Tendon Injury Using Mesenchymal Stem Cells (Allo-ASC) |
| NCT01253135 | PHASE1 | COMPLETED | Study to Determine if Fibrin Affects the Ability of a Wound to Heal |
| NCT02584153 | PHASE1 | WITHDRAWN | A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery |
| NCT03321201 | Not specified | RECRUITING | Cauterization Versus fibrin Glue for Conjunctival Autografting in Primary Pterygium Surgery |
| NCT06281483 | Not specified | RECRUITING | PRP Versus PRF Versus Conventional Treatment in Chronic Non-healing Skin Ulcers |
| NCT07596758 | Not specified | NOT_YET_RECRUITING | Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics |
| NCT00504582 | Not specified | COMPLETED | Fibrin Melanoma Axillary Node Study in Patients With Melanoma |
| NCT00506311 | Not specified | COMPLETED | Evaluating the Use of Fibrin Tissue Adhesive in Melanoma Patients |
| NCT01000116 | Not specified | COMPLETED | Fibrin Glue Versus Tacked Fixation in Groin Hernia Repair (TAPP) |
| NCT01020825 | Not specified | COMPLETED | Long-term Safety and Efficacy of Adipose-derived Stem Cells to Treat Complex Perianal Fistulas in Patients Participating in the FATT-1 Randomized Controlled Trial |
| NCT01597011 | Not specified | COMPLETED | Long-term Follow-up After Laparoscopic Inguinal Hernia Repair Using Tisseel for Mesh Fixation |
| NCT02138019 | Not specified | COMPLETED | The Application of Fibrin Glue (Tissucol Duo Quick) in External Eye Surgeries |
| NCT02300246 | Not specified | WITHDRAWN | Clinical, Histological and Micro-computed Tomographic Evaluation of Neoformed Tissue in Post-extraction Sockets Covered With Platelet-rich Fibrin (PRF) Membrane: a Randomized Controlled Trial |
| NCT02397122 | Not specified | COMPLETED | Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment |
| NCT02438462 | Not specified | COMPLETED | Soluble Fibrin for Diagnosing Pulmonary Embolism |
| NCT02523937 | Not specified | COMPLETED | Evaluation of Soluble Fibrin in Thrombosis Exclusion |
| NCT02552381 | Not specified | COMPLETED | Evaluation of Fibrin Structure Marker in Cancer Patients Treated and Not Treated With LMWH |
| NCT02890680 | Not specified | COMPLETED | Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery |
| NCT03408418 | Not specified | COMPLETED | L-PRF in Alveolar Ridge Preservation |
| NCT04144829 | Not specified | UNKNOWN | Platelet-rich Fibrin Versus HIFU in Management of Stress Urinary Incontinence |
| NCT05422196 | Not specified | COMPLETED | Evaluation of Computer-Guided Secondary Alveolar Cleft Bone Grafting With and Without Platelet-Rich Fibrin |
| NCT05831267 | Not specified | COMPLETED | Fibrin Glue Versus Titanium Platelet-rich Fibrin in Lateral Sinus Lifting |
| NCT06071455 | Not specified | UNKNOWN | The Effect of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Canine Retraction |
| NCT06198322 | Not specified | UNKNOWN | Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Root Resorption |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).