Fluoride Ion

Summary

Fluoride Ion (CHEMBL1362) is an approved small molecule.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• Clinical trials: 131
• Chemistry: 18.99840316 Da · F-

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1362
Name	Fluoride Ion
Type	Small molecule
Max phase	3
FDA approved	yes
PubChem CID	28179
ChEBI	CHEBI:17051
Molecular formula	F-
Molecular weight	18.99840316
InChIKey	KRHYYFGTRYWZRS-UHFFFAOYSA-M

SMILES: [F-]

IUPAC name: fluoride

Also known as: Fluoride ion, Fluoride anion, fluoride, fluoride ion, Fluoride

Parent form; salt/anhydrous children: CHEMBL1248

Targets

Targets

Broader ChEMBL bioactivity targets: 2 (assay-derived). Sample: Carbonic anhydrase 13, Carbonic anhydrase 4.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

0 indications (0 at ChEMBL trial phase 4).

Clinical trials

Total trials: 131.

Phase distribution

Phase	Trials
Not specified	58
PHASE3	43
PHASE4	8
PHASE2	8
PHASE1	7
EARLY_PHASE1	6
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02360995	PHASE4	COMPLETED	The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US
NCT02490592	PHASE4	COMPLETED	Comparison of the Effect of Fluoride Remineralizer Gel and Foam
NCT02592278	PHASE4	COMPLETED	Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars
NCT03315312	PHASE4	UNKNOWN	Occlusal Caries Management in First Permanent Molars in Child Dental Care
NCT04561960	PHASE4	COMPLETED	Efficacy of Miswak in Oral Hygiene Maintenance
NCT05810389	PHASE4	COMPLETED	EVALUATION OF AN ALTERNATIVE TECHNIQUE FOR THE APPLICATION OF SODIUM FLUOROPHOSPHATE: A 2-YEARS DOUBLE-BLIND RCT
NCT06426108	PHASE4	COMPLETED	Interventions to Control Hypersensitivity Pain in Teeth With Insisive Molar Hypomineralization
NCT07579403	PHASE4	COMPLETED	Fluoride vs Probiotic Toothpaste for Caries Prevention
NCT05542667	PHASE3	NOT_YET_RECRUITING	Comparative Evaluation of Giomer Varnish vs Fluoride Varnish as Desensitizing Agents in Teeth With MIH
NCT07265830	PHASE3	NOT_YET_RECRUITING	Building Adaptive School-based Interventions for Caries
NCT07442136	PHASE3	ACTIVE_NOT_RECRUITING	Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion
NCT00066950	PHASE3	COMPLETED	Prevention Management Model for Early Childhood Caries (MAYA Project)
NCT00066963	PHASE3	COMPLETED	Fluoride Varnish Randomized Clinical Trial
NCT00067353	PHASE3	COMPLETED	Yakima Head Start Fluoride Varnish Study
NCT00435500	PHASE3	UNKNOWN	Fluoride Varnish in the Prevention of Dental Caries in Aboriginal and Non-aboriginal Children
NCT00758290	PHASE3	COMPLETED	Clinical Study to Evaluate Dental Plaque
NCT00758394	PHASE3	COMPLETED	Clinical Study to Compare Dental Plaque Control
NCT00758563	PHASE3	COMPLETED	Train New Examiners Via Modified Gingival Margin Plaque
NCT00759031	PHASE3	COMPLETED	Investigation of Dental Plaque and Gingival Index
NCT00759187	PHASE3	COMPLETED	Evaluate Clinical Research From Commerical Oral Care Products
NCT00761930	PHASE3	COMPLETED	Compare the Clinical Efficacy of Prototype Toothpastes.
NCT00762177	PHASE3	COMPLETED	Investigate Oral Bacteria in Adult Population
NCT00762450	PHASE3	COMPLETED	Effect on Bacterial Glycolytic Acid Formation on Plaque
NCT00762515	PHASE3	COMPLETED	Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes
NCT00762619	PHASE3	COMPLETED	Clinical Study to Examine Brushing on Dental Implants
NCT00762762	PHASE3	COMPLETED	Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population
NCT00762853	PHASE3	COMPLETED	Development of Clinical Method to Triclosan Retention in Plaque Following Brushing
NCT00763048	PHASE3	COMPLETED	Collection of Gingival Crevicular Fluid From Periodontitis Patients
NCT00763165	PHASE3	UNKNOWN	Periodontal Disease and Cardiovascular Disease
NCT00763256	PHASE3	COMPLETED	The Effect of Periodontal Treatment and the Use of Dentifrice on Glycaemic Control in Diabetics
NCT00763269	PHASE3	COMPLETED	The Efficacy of a Toothpaste to Reduce Sensitivity
NCT00765167	PHASE3	COMPLETED	Training and Calibration of Dental Examiners
NCT00926029	PHASE3	COMPLETED	Compare the Clinical Efficacy of Prototype Toothpastes
NCT00926328	PHASE3	COMPLETED	Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis
NCT00966953	PHASE3	COMPLETED	Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.
NCT00981825	PHASE3	COMPLETED	Efficacy of Salivary Bacteria and Post Brushing
NCT01024738	PHASE3	COMPLETED	Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse
NCT01072201	PHASE3	COMPLETED	To Access the Effects of Mucositis in Adults With Dental Implants
NCT01116739	PHASE3	COMPLETED	Preventing Caries in Preschoolers: Testing a Unique Service Delivery Model in American Indian Head Start Programs
NCT01607411	PHASE3	COMPLETED	A Clinical Study to Evaluate Experimental Children’s Toothpastes in an In-Situ Caries Model

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No CPIC/DPWG dosing guideline or drug-level clinical/variant annotations in PharmGKB for this molecule.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).