Ginkgo
drugOn this page
Also known as B1260Common ginkgo leafCommon ginkgo wholeEGB 761EGB-761Ginkgo bilobaGinkgo biloba extractGinkgo biloba leafGinkgo biloba leaf dry extractGinkgo biloba leaf extractGinkgo biloba leaf powderGinkgo biloba leaf tinctureGinkgo biloba wholeext.Ginkgo foliumGinkgo folium (ginkgo biloba l.)Ginkgo leafGinkgo leaf (ginkgo biloba l.)Ginkgo macrophylla leaf
Summary
Ginkgo (CHEMBL2108466) is an approved unknown (ATC N06DX02); indicated across 17 conditions including dementia and vestibular neuronitis.
At a glance
- Status: Approved (max clinical phase 4)
- Modality: Unknown
- ATC class: N06DX02
- Indications: 17 conditions
- Clinical trials: 39
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL2108466 |
| Name | Ginkgo |
| Type | Unknown |
| Max phase | 4 |
| ATC | N06DX02 |
Also known as: B1260, Common ginkgo leaf, Common ginkgo whole, EGB 761, EGB-761, Ginkgo, Ginkgo biloba, Ginkgo biloba extract, Ginkgo biloba leaf, Ginkgo biloba leaf dry extract, Ginkgo biloba leaf extract, Ginkgo biloba leaf powder
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
17 indications (1 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| dementia | 4 | MONDO:0001627 | HP:0000726 |
| vestibular neuronitis | 3 | MONDO:0006008 | EFO:0007537 |
| sleep disorder | 3 | MONDO:0100081 | EFO:0008568 |
| open-angle glaucoma | 2 | MONDO:0005338 | EFO:0004190 |
| physiological sexual disorder | 2 | MONDO:0002134 | EFO:0004714 |
| Alzheimer disease | 2 | MONDO:0004975 | MONDO:0004975 |
| Parkinson disease | 2 | MONDO:0005180 | MONDO:0005180 |
| Friedreich ataxia | 2 | MONDO:0100339 | MONDO:0100339 |
| vitiligo | 1 | MONDO:0008661 | EFO:0004208 |
| skin disorder | 1 | MONDO:0005093 | EFO:0000701 |
| type 2 diabetes mellitus | 1 | MONDO:0005148 | MONDO:0005148 |
| multiple sclerosis | 1 | MONDO:0005301 | MONDO:0005301 |
| retinitis pigmentosa | 0 | MONDO:0019200 | MONDO:0019200 |
4 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 39.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 11 |
| PHASE2 | 10 |
| PHASE4 | 6 |
| PHASE3 | 5 |
| PHASE1/PHASE2 | 3 |
| PHASE1 | 2 |
| PHASE2/PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06495476 | PHASE4 | NOT_YET_RECRUITING | Study on Ginkgo Biolba Extract Fifty and Mild Cognitive Impairment Associated With CSVD |
| NCT07579689 | PHASE4 | NOT_YET_RECRUITING | Effects of Ginkgo Biloba on Blood Biomarkers in Mild Cognitive Impairment |
| NCT00042172 | PHASE4 | COMPLETED | Treatment for Early Memory Loss |
| NCT01046292 | PHASE4 | COMPLETED | Effect of Ginkgo Biloba Special Extract LI 1370 on Dual-tasking in Patients With MCI |
| NCT02982603 | PHASE4 | COMPLETED | Efficacy and Safety of Qinggongshoutao Bolus in aMnestic Mild Cognitive Impairment |
| NCT04846179 | PHASE4 | COMPLETED | To Evaluate the Effect of Ginkgo Biloba Extract on Optic Nerve Head Perfusion Examined Using OCTA |
| NCT00010803 | PHASE3 | COMPLETED | Ginkgo Biloba Prevention Trial in Older Individuals |
| NCT00010920 | PHASE3 | COMPLETED | Preventing Cognitive Decline With Alternative Therapies |
| NCT00046891 | PHASE3 | COMPLETED | EGb761 in Maintaining Mental Clarity in Women Receiving Chemotherapy for Newly Diagnosed Breast Cancer |
| NCT01637168 | PHASE3 | WITHDRAWN | Comparison of the Panax Ginseng + Associations to Ginkgo Biloba in the Treatment of Cognitive Function Disorders |
| NCT02098330 | PHASE3 | COMPLETED | The Efficacy of Steroid Therapy in Vestibular Neuritis |
| NCT06403787 | PHASE2/PHASE3 | COMPLETED | Effect of Aerobic Training and Ginkgo Biloba on Lipids Levels in HIV-positive Patients Undergoing Antiretroviral Treatment |
| NCT04525144 | PHASE2 | RECRUITING | EGb 761 in the Syndrome of MCI With Concomitant CVD |
| NCT06813274 | PHASE2 | NOT_YET_RECRUITING | Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling |
| NCT07287852 | PHASE2 | ENROLLING_BY_INVITATION | A Pilot Study to Examine the Effect of Egb761 on Plasma Biomarker Levels and on Cognitive Function in Patients With MCI |
| NCT00010842 | PHASE1/PHASE2 | COMPLETED | Natural Antioxidants in the Treatment of Multiple Sclerosis |
| NCT00029692 | PHASE2 | COMPLETED | Effects of Ginseng and Ginkgo on Drug Disposition in Man |
| NCT00032474 | PHASE1/PHASE2 | COMPLETED | Ginkgo Biloba Extract and the Insulin Resistance Syndrome |
| NCT00034021 | PHASE2 | COMPLETED | Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction |
| NCT00070954 | PHASE1/PHASE2 | TERMINATED | Ginkgo Biloba to Improve Short-Term Memory Losses Associated With Electroconvulsive Therapy (ECT) |
| NCT00841321 | PHASE2 | COMPLETED | Trial of Ginkgo as a Treatment for Cognitive Problems in Multiple Sclerosis |
| NCT01139281 | PHASE2 | COMPLETED | The Protective Effect of Ginkgo Biloba Extract on Cisplatin-induced Ototoxicity in Humans |
| NCT01416818 | PHASE2 | UNKNOWN | Treatment of Depression in Parkinson’s Disease |
| NCT02376114 | PHASE2 | COMPLETED | Ginkgo Biloba and Ocular Blood Flow in Primary Open-angle Glaucoma |
| NCT02425436 | PHASE2 | COMPLETED | Role of Ginkgo Biloba Extract in IUGR |
| NCT00011063 | PHASE1 | COMPLETED | Effect of Ginkgo Biloba on Phenytoin Elimination |
| NCT00907062 | PHASE1 | COMPLETED | Ginkgo Biloba for the Treatment of Vitiligo Vulgaris in Adolescents |
| NCT02386852 | EARLY_PHASE1 | COMPLETED | Ginseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity |
| NCT06140888 | Not specified | NOT_YET_RECRUITING | Effect of Ginkgo Biloba Extract on Cognitive Function in Acute Ischemic Stroke |
| NCT01524380 | Not specified | COMPLETED | Ginkgo Biloba Extract for Schizophrenia |
| NCT01663467 | Not specified | WITHDRAWN | Efficacy of Internet and Smartphone Application-delivered Tinnitus Retraining Therapy |
| NCT03125551 | Not specified | WITHDRAWN | ROTEM and Dietary Supplements |
| NCT03216681 | Not specified | COMPLETED | Hoat Huyet Nhat Nhat Versus Tanakan for Treatment of Symptoms Related to the Insufficient Blood Supply to the Brain |
| NCT03425045 | Not specified | COMPLETED | Repetitive Transcranial Magnetic Stimulation for Chronic Subjective Tinnitus |
| NCT03475823 | Not specified | COMPLETED | Cognitive and Blood Flow Effects of Mountain Tea |
| NCT04121728 | Not specified | UNKNOWN | Modulation of Attention in Event Related Potential (ERPs) as a Marker of Early Cognitive Decline by Ginkgo Biloba |
| NCT05258123 | Not specified | COMPLETED | Ginkgo Biloba Extract in the Treatment of Schizophrenia |
| NCT05591144 | Not specified | COMPLETED | Short-term Oral Prednisone for Acute Subjective Tinnitus |
| NCT06124703 | Not specified | UNKNOWN | Different Dosing Regimens of STOP-AST |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: dementia, vestibular neuronitis, sleep disorder