Hetastarch

Summary

Hetastarch (CHEMBL2108448) is a phase-3 clinical-stage unknown (ATC B05AA07); indicated across 4 conditions including peripheral vascular disease and infertility disorder.

At a glance

• Status: Max clinical phase 3 (not approved)
• Modality: Unknown
• ATC class: B05AA07
• Indications: 4 conditions
• Clinical trials: 28

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL2108448
Name	Hetastarch
Type	Unknown
Max phase	3
ATC	B05AA07

Also known as: Hespan, Hetastarch, Hydroxyethyl starch, Hydroxyethylstarch, HETASTARCH

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

4 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
peripheral vascular disease	2	MONDO:0005294	EFO:0003875
infertility disorder	0	MONDO:0005047	EFO:0000545
pulmonary edema	0	MONDO:0006932	EFO:1001134

1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 28.

Phase distribution

Phase	Trials
Not specified	12
PHASE4	11
PHASE3	2
PHASE2	2
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00308100	PHASE4	TERMINATED	Hydroxyethyl Starch (130/0.4) for Intravascular Volume Therapy in Liver Transplantation
NCT00308126	PHASE4	COMPLETED	Study to Evaluate the Effect of Hydroxyethyl Starch (HES) in Complications of Patients After Abdominal Surgery
NCT00431743	PHASE4	UNKNOWN	Fluid Infusion During Breast Surgery
NCT00517127	PHASE4	COMPLETED	Crystalloids Versus Colloids During Surgery
NCT00542516	PHASE4	COMPLETED	Comparison Between Two Techniques of Volemic Expansion in Hip Replacement Arthroplasty
NCT01348659	PHASE4	COMPLETED	Effects of Hypertonic Saline-HES Solution on Extracellular Water in Cardiac Surgery Patients
NCT01415284	PHASE4	UNKNOWN	ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia
NCT02009033	PHASE4	COMPLETED	Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery
NCT02064075	PHASE4	COMPLETED	The Mortality and Changes in Quality of Life of Patients Suffering From SAH With Different Hydration Strategies
NCT02393196	PHASE4	UNKNOWN	Colloid Preload Versus Colloid Coload During Cesarean Deliveries
NCT03350217	PHASE4	COMPLETED	A Comparison of Eleview Versus Hetastarch as Injectate for EMR
NCT00307138	PHASE3	COMPLETED	Hetastarch and Bleeding Complications After Off-Pump Coronary Bypass Surgery
NCT02584868	PHASE3	COMPLETED	Colloids in Pediatric Cardiac Surgery: Comparison Between a Balanced and a Non-balanced Colloid
NCT01192581	PHASE2	UNKNOWN	Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection as Adjunctive Therapy in Subjects With Internal Carotid Artery Hypoperfusion
NCT02622126	PHASE2	COMPLETED	Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia
NCT01530490	EARLY_PHASE1	COMPLETED	Cabergoline and Hydroxyethyl Starch in Ovarian Hyperstimulation Syndrome Prevention
NCT05728645	Not specified	ACTIVE_NOT_RECRUITING	Colloid Infusion for Optimal Outcomes In Non-cardiac Surgery (COIN Trial)
NCT01826253	Not specified	COMPLETED	Observational Study of Oxygen Delivery During a Fractional Fluid Expansion
NCT02306213	Not specified	COMPLETED	Effect of Hydroxyethylstarch 6% 130/0.4 Administration on Renal Function After Cardiac Surgery
NCT02361736	Not specified	COMPLETED	Evaluate the Nephrotoxicity by 6% Hydroxyethyl Starch 130/0.4 in Old Patients During Orthopaedic Surgery
NCT02882074	Not specified	COMPLETED	Endothelial Function After Cardiac Surgery
NCT03048162	Not specified	COMPLETED	The Effects of Intravenous Fluids on Perfusion Index and Pleth Variability Index
NCT03306914	Not specified	COMPLETED	Comparing Human Albumin Versus Hydroxyethylstarch in Renal Transplant Recipients
NCT03674684	Not specified	COMPLETED	ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation
NCT03681847	Not specified	COMPLETED	Crystalloids Versus Colloids Versus Hypertonic Saline as a Co-load During Spinal Anesthesia.
NCT04465539	Not specified	COMPLETED	The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning
NCT04567433	Not specified	COMPLETED	Days Alive and Out of Hospital for Patients With Sepsis
NCT05475990	Not specified	COMPLETED	Comparison of Hydroxyethyl Starch and Crystalloid Coload Combined With Norepinephrine Infusion for Hypotension

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).