Hyaluronic Acid (Non-Animal Stabilized)
drugOn this page
Also known as DurolaneHyaluronan (non animal)Hyaluronic acid (nasha)NashaPerlaneRestylane
Summary
Hyaluronic Acid (Non-Animal Stabilized) (CHEMBL4594585) is a phase-3 clinical-stage unknown; indicated across 3 conditions including osteoarthritis, knee and alopecia areata.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Unknown
- Indications: 3 conditions
- Clinical trials: 72
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL4594585 |
| Name | Hyaluronic Acid (Non-Animal Stabilized) |
| Type | Unknown |
| Max phase | 3 |
Also known as: Durolane, Hyaluronan (non animal), Hyaluronic acid (nasha), Hyaluronic acid (non-animal stabilized), Nasha, Perlane, Restylane, HYALURONIC ACID (NON-ANIMAL STABILIZED)
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
3 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| osteoarthritis, knee | 3 | MONDO:0005416 | EFO:0004616 |
| alopecia areata | 2 | MONDO:0005340 | EFO:0004192 |
| osteoarthritis | 2 | MONDO:0005178 | MONDO:0005178 |
Clinical trials
Total trials: 72.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 50 |
| PHASE4 | 11 |
| PHASE3 | 6 |
| PHASE2 | 5 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00765583 | PHASE4 | COMPLETED | A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules. |
| NCT00852241 | PHASE4 | COMPLETED | Rejuvenation of the Lower Eyelid Using a Combination of Two Hyaluronic Acid Fillers - a Pilot Study |
| NCT00977704 | PHASE4 | COMPLETED | Study of Restylane and Perlane in the Correction of Peri-Oral Wrinkles |
| NCT01806207 | PHASE4 | COMPLETED | Durolane Compared to Saline in Patients With Unilateral Knee Osteoarthritis |
| NCT02297503 | PHASE4 | COMPLETED | Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster |
| NCT02297516 | PHASE4 | COMPLETED | Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment |
| NCT02312154 | PHASE4 | COMPLETED | Changing in Skin Physiology After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces |
| NCT03127384 | PHASE4 | COMPLETED | Performance and Safety of Restylane Lidocaine for Treatment of Depressed Facial Acne Scars |
| NCT03381040 | PHASE4 | COMPLETED | Midfacial Product Selection |
| NCT03460158 | PHASE4 | COMPLETED | Prospective Evaluation of Facial Cosmetic Procedures |
| NCT03746834 | PHASE4 | COMPLETED | NASHA/Dx as a Perianal Implant for the Treatment of Persistent Fecal Incontience After Anorectal Malformation |
| NCT00444626 | PHASE3 | COMPLETED | A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs) |
| NCT00764257 | PHASE3 | COMPLETED | PREVELLE Shape (CX002) Dermal Filler Protocol |
| NCT01529203 | PHASE3 | COMPLETED | Subjects’ Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range |
| NCT02179606 | PHASE3 | COMPLETED | Clinical Study to Evaluate the Efficacy and Safety of Dermalax Implant Plus |
| NCT02179619 | PHASE3 | COMPLETED | Clinical Study to Evaluate the Efficacy and Safety of Dermalax(Deep) in Correction of Nasolabial Folds |
| NCT04174131 | PHASE3 | COMPLETED | Restylane + Lidocaine and Restylane Lyft for the Treatment of Nasolabial Folds |
| NCT00414544 | PHASE2 | COMPLETED | Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds |
| NCT01265459 | PHASE2 | COMPLETED | Different Volumes of Durolane in Knee OA |
| NCT01697423 | PHASE2 | COMPLETED | Comparative Assessment of Intra-articular Knee Injections of Platelet-rich Plasma (PRP) and Hyaluronic Acid in the Treatment of Knee Osteoarthritis |
| NCT01797432 | PHASE2 | COMPLETED | Combined Restylane and Triamcinolone Acetonide Injections for the Treatment of Alopecia Areata |
| NCT03324997 | PHASE2 | WITHDRAWN | Restylane Silk for Treatment of Chest Wrinkles |
| NCT04162496 | Not specified | ACTIVE_NOT_RECRUITING | Restylane Refyne for Correction of Horizontal Neck Rhytides |
| NCT06665477 | Not specified | RECRUITING | Evaluate the Effectiveness and Safety of Restylane Volyme in the Treatment of Temple Hollowing |
| NCT07063511 | Not specified | RECRUITING | Pan-Facial Layering of Hyaluronic Acid Filler |
| NCT07079397 | Not specified | RECRUITING | Hyaluronic Acid Filler Migration |
| NCT07359079 | Not specified | ACTIVE_NOT_RECRUITING | The Correction of Midface Volume Deficiency and/or Midface Contour Deficiency |
| NCT07367204 | Not specified | ACTIVE_NOT_RECRUITING | Randomized Masked Trial of Injectable Cross-Linked Hyaluronic Acid for Moderate-to-Severe Nasolabial Folds |
| NCT00407914 | Not specified | COMPLETED | Safety and Effectiveness of Aquamid as Compared to Restylane for the Aesthetic Treatment of Nasolabial Folds |
| NCT00605826 | Not specified | COMPLETED | A Randomized, Blinded, Multicenter Study to Evaluate NASHA/Dx for the Treatment of Fecal Incontinence |
| NCT00797459 | Not specified | COMPLETED | Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds |
| NCT00823069 | Not specified | COMPLETED | Safety Study That Compares Perlane to Perlane With Lidocaine (Perlane-L) While Correcting Wrinkles in the Area Around Your Nose |
| NCT01295580 | Not specified | COMPLETED | Comparative Study of Safety and Efficacy of Two Hyaluronic Acids for the Treatment of Knee Osteoarthritis Pain |
| NCT01431755 | Not specified | COMPLETED | A Study of Treatment Preference During Cheek Contouring Comparing Restylane® SubQ With and Without the Addition of Lidocaine Hydrochloride |
| NCT01753830 | Not specified | TERMINATED | Durolane Versus Phosphate Buffered Saline (PBS) in Knee Osteoarthritis |
| NCT02119780 | Not specified | UNKNOWN | Clinical Study to Evaluate the Efficacy and Safety of YVOIRE® Contour Compared With Restylane SubQ™ Injected Into the Anteromedial Malar Region |
| NCT02179736 | Not specified | COMPLETED | A Post Market Evaluation After Treatment of Nasolabial Folds |
| NCT02216851 | Not specified | COMPLETED | Restylane Perlane to Shape the Nasal Dorsum and/or Nasal Root |
| NCT02432742 | Not specified | COMPLETED | Efficacy and Safety of Restylane Perlane Compared to Restylane for Correction of Moderate and Severe Nasolabial Folds |
| NCT02545608 | Not specified | COMPLETED | Safety and Efficacy of Restylane Vital for Skin Rejuvenation of Dorsal Hands |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: osteoarthritis, knee