Hyaluronic Acid

Summary

Hyaluronic Acid (CHEMBL5314376) is an approved unknown (ATC S01KA51); indicated across 15 conditions including osteoarthritis, knee and oral submucous fibrosis.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Unknown
• ATC class: S01KA51
• Indications: 15 conditions
• Clinical trials: 185

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL5314376
Name	Hyaluronic Acid
Type	Unknown
Max phase	4
ATC	S01KA51

Also known as: Hyaluronan, Hyaluronate, Hyaluronic acid, HYALURONIC ACID, HYALURONIC-ACID, hyaluronic-acid

Parent form; salt/anhydrous children: CHEMBL4594244

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

9 diseases in clinical trials (phase 1–3, investigational — not approved indications). Highest ChEMBL trial phase per disease; a non-cancer approved use is occasionally logged at phase 3 here.

Disease (in trials)	Phase	MONDO	EFO
osteoarthritis, knee	3	MONDO:0005416	EFO:0004616
oral submucous fibrosis	3	MONDO:0018166	EFO:1001818
osteoarthritis	3	MONDO:0005178	MONDO:0005178
premature ejaculation	3	MONDO:0001780	EFO:0803321
disease of the tendon	3	MONDO:0100010	MONDO:0004857
periodontitis	2	MONDO:0005076	EFO:0000649
injury	2	MONDO:0021178	EFO:0000546
rotator cuff syndrome	1	MONDO:0007028	EFO:1001250
presbyopia	1	MONDO:0001330	MONDO:0001330

6 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 185.

Phase distribution

Phase	Trials
Not specified	84
PHASE4	40
PHASE3	20
PHASE1/PHASE2	16
PHASE2	11
PHASE1	6
PHASE2/PHASE3	5
EARLY_PHASE1	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04671914	PHASE4	RECRUITING	Prevalence of Intrauterine Adhesions After D&C With or Without Antiadhesion Gel After Abortion in Second Trimester.
NCT00429520	PHASE4	COMPLETED	Hyaluronic Acid Filler IMD1 Basic for Correction of Nasolabial Folds
NCT00731289	PHASE4	COMPLETED	Gait Patterns After Intraarticular Treatment of Patients With Osteoarthritis of the Knee
NCT00778076	PHASE4	UNKNOWN	The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics
NCT01290497	PHASE4	COMPLETED	Efficacy and Safety of 3 Different Dosage Regimens of Hyaluronic Acid in Patients With Knee Osteoarthritis (OA)
NCT01387620	PHASE4	COMPLETED	Comparison of DisCoVisc and Hydroxypropylmethylcellulose 2%
NCT01524913	PHASE4	COMPLETED	A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint (TMJ) Dysfunction
NCT01670578	PHASE4	COMPLETED	Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology
NCT01838252	PHASE4	WITHDRAWN	Hyaluronic Acid Gels for Lower Lid Retraction
NCT01948583	PHASE4	COMPLETED	Humectant Activity of a New Formulation of Gynomunal® Vaginalgel
NCT02014428	PHASE4	COMPLETED	Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis
NCT02034890	PHASE4	WITHDRAWN	Intravesical Instillation of Hyaluronic Acid to Decrease Incidence of Urinary Tract Infection
NCT02086474	PHASE4	COMPLETED	Daily Activity and Gait Analysis After Viscosupplement Injection Among Hip Osteoarthritis Patients
NCT02366676	PHASE4	COMPLETED	Efficacy of IARULIL® in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract
NCT02625727	PHASE4	UNKNOWN	Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis
NCT02629380	PHASE4	COMPLETED	Early Viscosupplementation After Partial Meniscectomy: a Randomized Controlled Trial
NCT02949466	PHASE4	UNKNOWN	Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis
NCT02984228	PHASE4	COMPLETED	Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis
NCT03077009	PHASE4	UNKNOWN	Functional Improvement and UTC of the Achilles Tendon After Sodium Hyaluronate Injection for Plantaris Syndrome
NCT03157193	PHASE4	COMPLETED	Effect of Hyaluronic Acid on Perimplantitis
NCT03186755	PHASE4	UNKNOWN	Clinical Evaluation of Hylo-Dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis
NCT03211650	PHASE4	COMPLETED	Efficacy of Hyaluronic Acid and Platelet-rich Plasma Combination in Knee Osteoarthritis
NCT03238183	PHASE4	UNKNOWN	Effects of Dextrose on Knee Osteoarthritis
NCT03245463	PHASE4	COMPLETED	Evaluation of Methods of Teaching Self-management Strategies to Patients With Symptomatic Knee Osteoarthritis
NCT03431584	PHASE4	COMPLETED	Effects on the Pain of an Infiltration by Acid Hyaluronic Association and Corticoids Versus Only Corticoids in the Rhizarthrosis.
NCT03691467	PHASE4	COMPLETED	the Effect of Topical Application of Hyaluronic Acid on Immediate Dental Implant
NCT03692026	PHASE4	UNKNOWN	Assessment of Immediate Implant Stability When Adding Mixture of Hyaluronic Acid and Melatonin
NCT03825133	PHASE4	COMPLETED	The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid
NCT04110587	PHASE4	COMPLETED	Hyaluronic Acid Evaluation as Adjuvant to Temporomandibular Joint Arthroscopy
NCT04117893	PHASE4	COMPLETED	Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients
NCT04373603	PHASE4	WITHDRAWN	Use of Tranexamic Acid in Facial Fillers
NCT04586361	PHASE4	UNKNOWN	Prospective Analysis of Introperative RegenLab PRP and Hyaluronic Acid in Patients With Knee ACL Tear
NCT04692558	PHASE4	UNKNOWN	Effect of Hyaluronic Acid on Gingival Recession Treatment
NCT05291650	PHASE4	COMPLETED	Ultrasound-guided Injection of Glucocorticoid Into Infrapatellar Fat Pad in Patients With Knee Osteoarthritis
NCT05768243	PHASE4	COMPLETED	Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis
NCT05818007	PHASE4	COMPLETED	Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy
NCT05834517	PHASE4	COMPLETED	‘‘Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis
NCT06176937	PHASE4	COMPLETED	Hyaluronic Acid Gel in Ridge Preservation
NCT06426199	PHASE4	UNKNOWN	Chitosan-Hyaluronate Gel Mixture Vs Hyaluronic for Internal Derangement
NCT06872151	PHASE4	COMPLETED	Evaluation of the Effectiveness of a Topical Medical Device in Wound Healing and Symptom Relief in the Postoperative Period of Open Excisional Hemorrhoidectomy (The Emor Study)
NCT05086939	PHASE3	ACTIVE_NOT_RECRUITING	Multicenter Clinical Trial Comparing Treatment with Allogeneic Mesenchymal Cells Versus Autologous Mesenchymal Cells and Versus Active Control with Hyaluronic Acid in Patients with Knee Osteoarthritis.
NCT05824806	PHASE3	NOT_YET_RECRUITING	Knee Osteoarthritis Treatment With Platelet-rich Plasma
NCT06238934	PHASE3	NOT_YET_RECRUITING	Treatment of Knee Osteoarthritis With Bone Marrow Aspirate Matrix: Prospective, Randomized Trial
NCT00728611	PHASE2/PHASE3	COMPLETED	Preparation Rich in Growth Factors (PRGF) Treatment for Osteoarthritis of the Knee
NCT01270412	PHASE2/PHASE3	UNKNOWN	Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis
NCT01787630	PHASE2/PHASE3	UNKNOWN	To Evaluate the Technique and Effects of Separating the Prostate and Rectum With Hyaluronic Acid During Radiotherapy
NCT02039531	PHASE3	COMPLETED	Effect Of Plasma Rich In Growth Factors In Knee Osteoarthritis
NCT02039804	PHASE3	UNKNOWN	Sodium Hyaluronate Injection and Corticosteroids in Trochanteric Bursitis: a Randomized Controlled Study.
NCT02063373	PHASE3	COMPLETED	Gait, Stair Climbing and Postural Stability in Knee Osteoarthritis Patients After Hyaluronic Acid Injection
NCT02211521	PHASE3	COMPLETED	Comparison of Autologous Platelet-rich Plasma With Hyaluronic Acid for the Treatment of Osteoarthritis of the Knee Joint
NCT02448407	PHASE3	COMPLETED	Intraarticular Injections of Platelet-rich Plasma in Pain’s Treatment of the Osteoarthritic Knee
NCT02714543	PHASE3	COMPLETED	Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study
NCT02790177	PHASE3	UNKNOWN	Role of Hyaluronic Acid in the Prevention of Post-operative Adhesions: a RCT
NCT02931357	PHASE3	COMPLETED	Study of a New Medical Device in Gel Formulation Versus Calgel® for the Topical Treatment of Teething in Infants
NCT03131882	PHASE2/PHASE3	UNKNOWN	Efficacy of Ultrasound Guided Hyaluronic Injection in Treatment of Trigger Finger
NCT03459833	PHASE3	COMPLETED	Glans Penis Augmentation by Hyaluronic Acid for Treatment of Premature Ejaculation
NCT03477630	PHASE3	COMPLETED	Treatment of Osteoarthrosis of the Knee With Platelet Rich Plasma, Comparative Study With Hyaluronic Acid
NCT03889925	PHASE2/PHASE3	COMPLETED	Effect of Different Injection Regimens of Autologous Conditioned Plasma for Knee Osteoarthritis
NCT04426721	PHASE3	UNKNOWN	Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis Compared With Hyaluronic Acid
NCT04438421	PHASE3	UNKNOWN	Efficacy of Hyaluronic-acid and Hydrogen-Peroxide Mouthwash in Gingivitis Treatment
NCT04438434	PHASE3	UNKNOWN	Evaluation of Hydrogen Peroxide and Hyaluronic Acid (BMG0703) in the Healing of Post-extraction Sites
NCT04972383	PHASE3	COMPLETED	Comparing Effect of Autologous Platelet-Rich Plasma Versus Hyaluronic Acid Treatment on Knee Osteoarthritis
NCT04980105	PHASE3	UNKNOWN	Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis
NCT05116306	PHASE3	UNKNOWN	Clinical and Radiographic Evaluation of Hyaluronic Acid Compared to Propylene Glycol as Vehicle for Double Antibiotic Paste in Lesion Sterilization and Tissue Repair Technique for Non-Vital Primary Molars
NCT05746676	PHASE3	UNKNOWN	Insulin Versus Hyaluronic Acid in Management of Periodontal Defects
NCT04711304	PHASE1/PHASE2	NOT_YET_RECRUITING	Evaluation of Safety and Efficacy of Wharton’s Jelly Compared to Hyaluronic Acid and Saline for Knee Osteoarthritis.
NCT06572904	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING	Effect of Intraarticular Injection of Tenoxicam and Hyaluronic Acid Versus Platelet-Rich Plasma and Hyaluronic Acid in Temporomandibular Joint Internal Derangement
NCT06694532	PHASE1/PHASE2	RECRUITING	EffIcacy Between Arthrocentesis With High Versus Low Molecular Weight Hyaluronic Acid in Treatment of TMJ Disorders
NCT00225095	PHASE1/PHASE2	COMPLETED	A Phase I/II Study of Chondrogen Delivered by Intra-Articular Injection Following Meniscectomy
NCT01076673	PHASE2	COMPLETED	Effect of Autologous Peripheral Blood Stem Cell Treatment on Articular Cartilage Regeneration
NCT01088191	PHASE1/PHASE2	COMPLETED	Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction
NCT01459640	PHASE2	UNKNOWN	Intra-Articular Autologous Bone Marrow Mesenchymal Stem Cells Transplantation to Treat Mild to Moderate Osteoarthritis
NCT01586312	PHASE1/PHASE2	COMPLETED	Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells
NCT01588925	PHASE2	COMPLETED	Hearing Preservation Using Dexamethasone and Hyaluronic Acid for Cochlear Implantation
NCT02091674	PHASE2	COMPLETED	Management of Acute Ankle Sprain With Sodium Hyaluronate
NCT02123368	PHASE1/PHASE2	COMPLETED	Treatment of Knee Osteoarthritis by Intra-articular Injection of Bone Marrow Mesenchymal Stem Cells
NCT02207608	PHASE2	COMPLETED	Influence of Hyaluronic Acid on Bacillus Calmette-Guérin Local Side Effects
NCT02265575	PHASE2	COMPLETED	Hylenex-Assisted Resuscitation in Kenya (HARK) Trial for the Management of Dehydration
NCT02580695	PHASE1/PHASE2	COMPLETED	A Study to Assess Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stromal Cells in Knee Osteoarthritis
NCT02709525	PHASE1/PHASE2	COMPLETED	Use of Hyaluronic Acid as a Therapeutic Strategy for Bone Repair in Human
NCT02776943	PHASE1/PHASE2	UNKNOWN	UCMSC Transplantation in the Treatment of Cartilage Damage
NCT02958761	PHASE2	COMPLETED	Treatment of Knee Arthrosis With Platelet-derived Growth Factors vs. Hyaluronic Acid.
NCT02967874	PHASE1/PHASE2	COMPLETED	Autologous Adipose-Derived Stromal Vascular Fraction Cells for Osteoarthritis Treatment
NCT03101163	PHASE2	COMPLETED	Efficacy and Safety Study of Intra-Articular Injections of Autologous Peripheral Blood Stem Cells Following Subchondral Drilling Surgery for the Treatment of Articular Cartilage Injury in the Knee
NCT03166865	PHASE1/PHASE2	UNKNOWN	Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis
NCT04198467	PHASE2	COMPLETED	To Evaluate the Optimum Dose of Platelet Rich Plasma in Knee Osteoarthritis and Compare Efficacy With Hyaluronic Acid
NCT04525066	PHASE2	COMPLETED	Phonosurgical Augmentation After Laser Resection of Early Glottic Carcinoma
NCT04766853	PHASE1/PHASE2	COMPLETED	Verification of the Efficacy/safety of the Intratympanic Drug Delivery for Hearing Loss
NCT05027581	PHASE2	COMPLETED	Chondrochymal® for Subjects With Knee Osteoarthritis (Knee OA)
NCT06437054	PHASE1/PHASE2	WITHDRAWN	Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss
NCT06469216	PHASE1/PHASE2	COMPLETED	Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis
NCT07437885	PHASE1/PHASE2	COMPLETED	Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession
NCT02698813	PHASE1	UNKNOWN	Safety Study of Filler Agent Composed of Umbilical Cord Mesenchymal Stem Cells and Hyaluronic Acid
NCT03047096	PHASE1	UNKNOWN	Intra-Articular, Single-shot Injection of Hyaluronic Acid and Corticosteroids in Knee Osteoarthritis
NCT03548662	PHASE1	COMPLETED	The Effect of Platelet Rich Plasma Injection Combined With Exercise Rehabilitation in Patients With Rotator Cuff Tear
NCT04893174	PHASE1	UNKNOWN	Mesenchymal Stem Cells for The Treatment of Knee Osteoarthritis (KOA).
NCT05001243	PHASE1	UNKNOWN	Comparison of a Compound With Pilocarpine and Brimonidine to Improve Near Vision in Healthy Presbyopic Patients
NCT05006911	PHASE1	UNKNOWN	Pilocarpine, Brimonidine, Oxymetazoline (PBO) Compound to Control Presbyopia Symptoms
NCT01464528	EARLY_PHASE1	UNKNOWN	Safety Study of Use of Hyaluronic Acid Gel To Prevent Intrauterine Adhesions In Hysteroscopic Surgery
NCT03800810	EARLY_PHASE1	UNKNOWN	Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord Blood for Osteoarthritis Management

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).