Hypochlorous Acid

Summary

Hypochlorous Acid (CHEMBL1616046) is an approved small-molecule EC 3.1.1.7 (acetylcholinesterase) inhibitor; indicated across 2 conditions.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• Indications: 2 conditions
• Clinical trials: 8
• Chemistry: 52.46 Da · ClHO

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1616046
Name	Hypochlorous Acid
Type	Small molecule
Max phase	4
FDA approved	yes
PubChem CID	24341
ChEBI	CHEBI:24757
Molecular formula	ClHO
Molecular weight	52.46
InChIKey	QWPPOHNGKGFGJK-UHFFFAOYSA-N

SMILES: OCl

IUPAC name: hypochlorous acid

ChEBI definition: A chlorine oxoacid with formula HOCl; a weak, unstable acid, it is the active form of chlorine in water.

Pharmacological roles (ChEBI): EC 3.1.1.7 (acetylcholinesterase) inhibitor, EC 2.5.1.18 (glutathione transferase) inhibitor.

Other ChEBI roles (chemical / environmental): human metabolite.

Also known as: Comfosy, Epicyn hydrogel, Hypochlorous acid, HYPOCHLOROUS ACID

Parent form; salt/anhydrous children: CHEMBL1334078, CHEMBL2251447

Patent coverage: 60,982 distinct patent families (133,392 SureChEMBL compound mentions), from 2 matched compound structure(s). One matched structure accounts for 133,309 (100%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

2 indications (0 at ChEMBL trial phase 4).

The 2 indication records carry no mapped disease name (EFO/MeSH-only); none shown.

Clinical trials

Total trials: 8.

Phase distribution

Phase	Trials
Not specified	4
PHASE4	2
PHASE2	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04018482	PHASE4	COMPLETED	Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study)
NCT05214196	PHASE4	COMPLETED	The Efficacy of Oral Antiseptics Against COVID-19
NCT00692757	PHASE2	UNKNOWN	Wound Antiseptic Study With Hypochlorous Acid & Iodopovidone
NCT03174756	PHASE2	COMPLETED	HYPOCHLOROUS ACID SUBSTANTIVITY AS ANTIPLAQUE AGENT (HOCl-SAP)
NCT07417202	Not specified	RECRUITING	Intraoperative Wound Irrigation for Pilonidal Disease
NCT05175027	Not specified	COMPLETED	Preoperative Antiseptic in Newborn Circumcision Comparison of Povidone Iodine and Hypochlorous Acid Used
NCT06760403	Not specified	COMPLETED	Efficacy of Hypochlorous Acid as a Postoperative Wound Antiseptic
NCT07466992	Not specified	COMPLETED	Comparison of Chlorhexidine and Hypochlorous Acid Mouthwash After Impacted Third Molar Surgery

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).