Isopropyl Alcohol
drugOn this page
Also known as AlcoholisopropylFEMA NO. 2929IsopropanolIsopropyl alcohol component of duraprepIsopropyl alcohol component of soluprepManugelMedi-swabMedi-swab hNSC-135801SteretsSterets hSwim-earZuragardSID17389846SID144204590SID144209673Iso-propanol
Summary
Isopropyl Alcohol (CHEMBL582) is an approved small molecule (ATC D08AX05); indicated across 12 conditions including prostate carcinoma and psoriatic arthritis.
At a glance
- Status: Approved (max clinical phase 4)
- Modality: Small molecule
- ATC class: D08AX05
- Indications: 12 conditions
- Clinical trials: 12
- Chemistry: 60.1 Da · C3H8O
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL582 |
| Name | Isopropyl Alcohol |
| Type | Small molecule |
| Max phase | 4 |
| FDA approved | yes |
| PubChem CID | 3776 |
| ChEBI | CHEBI:17824 |
| ATC | D08AX05 |
| Molecular formula | C3H8O |
| Molecular weight | 60.1 |
| InChIKey | KFZMGEQAYNKOFK-UHFFFAOYSA-N |
SMILES: CC(C)O
IUPAC name: propan-2-ol
ChEBI definition: A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.
Other ChEBI roles (chemical / environmental): protic solvent.
Also known as: Alcohol, isopropyl, FEMA NO. 2929, Isopropanol, Isopropyl alcohol, Isopropyl alcohol component of duraprep, Isopropyl alcohol component of soluprep, Manugel, Medi-swab, Medi-swab h, NSC-135801, Sterets
Patent coverage: 683,207 distinct patent families (1,818,166 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.
Targets
Targets
Broader ChEMBL bioactivity targets: 2 (assay-derived). Sample: Prelamin-A/C, Aldehyde dehydrogenase 1A1.
Bioactivity
ChEMBL activities: 1 potent at pChembl ≥ 5 of 2 total. Top 30 by potency (10 = 0.1 nM, 6 = 1 µM):
| Target | pChembl | Type | Value | Unit | Activity ID |
|---|---|---|---|---|---|
| LMNA | 5.95 | Potency | 1122 | nM | CHEMBL_ACT_3624351 |
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
12 indications (10 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| prostate carcinoma | 4 | MONDO:0005159 | EFO:0001663 |
| psoriatic arthritis | 4 | MONDO:0011849 | EFO:0003778 |
| rheumatoid arthritis | 4 | MONDO:0008383 | EFO:0000685 |
| ankylosing spondylitis | 4 | MONDO:0005306 | EFO:0003898 |
| ulcerative colitis | 4 | MONDO:0005101 | EFO:0000729 |
| anemia | 4 | MONDO:0002280 | EFO:0004272 |
| psoriasis | 4 | MONDO:0005083 | EFO:0000676 |
| burn | 4 | MONDO:0043519 | EFO:0009516 |
| infectious disease | 3 | MONDO:0005550 | EFO:0005741 |
3 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 12.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 4 |
| PHASE2 | 3 |
| PHASE4 | 2 |
| PHASE3 | 2 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05401292 | PHASE4 | RECRUITING | Skin Preparation for Elective Foot and Ankle Surgery |
| NCT06733506 | PHASE4 | COMPLETED | A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs |
| NCT01361997 | PHASE3 | COMPLETED | Isopropyl Alcohol Against Chlorhexidine - Isopropyl Alcohol as Antiseptics to Prevent Hemoculture’s Contamination |
| NCT04218110 | PHASE3 | COMPLETED | Preoperative Skin Preparation Study to Evaluate the Antimicrobial Capabilities of Four Test Substances |
| NCT04181463 | PHASE2 | NOT_YET_RECRUITING | Nasal Inhalation of Isopropyl Alcohol for the Treatment of Nausea in Patients With Cancer |
| NCT06836271 | PHASE2 | NOT_YET_RECRUITING | Cleaning the Biopsy Needle in TRUS Bx |
| NCT01824888 | PHASE2 | COMPLETED | Efficacy of JUC as Hand Rub Evaluated by Using European Standard 1500 |
| NCT02990013 | EARLY_PHASE1 | COMPLETED | AvenovaTM as a Sterile Skin Preparation Agent |
| NCT02015195 | Not specified | COMPLETED | Effective Treatments for Jellyfish Stings |
| NCT02320695 | Not specified | COMPLETED | Trial to Test if Antibiotic Ointments & Cream Will Sting After Application on a Minor Wound After Tape Stripping Injury |
| NCT04307550 | Not specified | COMPLETED | Inhaled Isopropyl Alcohol Versus Placebo to Manage Nausea at Electronic Dance Music Festivals |
| NCT04403191 | Not specified | COMPLETED | Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No CPIC/DPWG dosing guideline or drug-level clinical/variant annotations in PharmGKB for this molecule.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).