Mecrylate
drugOn this page
Also known as Aron alpha aCyanoacrylateMecrilateMecrilatoMethyl cyanoacrylate
Summary
Mecrylate (CHEMBL2106424) is a phase-3 clinical-stage small molecule; indicated across 3 conditions including injury and pilonidal sinus.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Small molecule
- Indications: 3 conditions
- Clinical trials: 30
- Chemistry: 111.1 Da · C5H5NO2
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL2106424 |
| Name | Mecrylate |
| Type | Small molecule |
| Max phase | 3 |
| FDA approved | no |
| PubChem CID | 8711 |
| Molecular formula | C5H5NO2 |
| Molecular weight | 111.1 |
| InChIKey | MWCLLHOVUTZFKS-UHFFFAOYSA-N |
SMILES: COC(=O)C(=C)C#N
IUPAC name: methyl 2-cyanoprop-2-enoate
Also known as: Aron alpha a, Cyanoacrylate, Mecrilate, Mecrilato, Mecrylate, Methyl cyanoacrylate, MECRYLATE
Patent coverage: 3,896 distinct patent families (12,782 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
3 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| injury | 2 | MONDO:0021178 | EFO:0000546 |
| pilonidal sinus | 1 | MONDO:0008249 | HP:0010769 |
1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 30.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 20 |
| PHASE4 | 3 |
| PHASE1 | 3 |
| PHASE2 | 2 |
| PHASE2/PHASE3 | 1 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00735358 | PHASE4 | COMPLETED | Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage |
| NCT00799851 | PHASE4 | COMPLETED | A Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection for Esophageal Varices |
| NCT02504723 | PHASE4 | COMPLETED | Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding |
| NCT04876976 | PHASE2/PHASE3 | COMPLETED | Isoamyl 2-Cyanoacrylate in the Urethro-cutaneous Fistula Repair |
| NCT06106971 | PHASE3 | UNKNOWN | Balloon-occluded Retrograde Transvenous Obliteration for Gastric Variceal Rebleeding |
| NCT00547638 | PHASE2 | COMPLETED | Study to Show Equivalence of DERMABOND PROTAPE to DERMABOND HVD for Wound Closure |
| NCT00659542 | PHASE2 | COMPLETED | Glubran Mesh Fixation in Lichtenstein Hernioplasty |
| NCT01399320 | PHASE1 | COMPLETED | Ghnnam Excision Technique for Pilonidal Sinus |
| NCT02115061 | PHASE1 | UNKNOWN | Gastric Varices Treatment: Coil + Cyanoacrylate Versus Cyanoacrylate |
| NCT06116539 | PHASE1 | UNKNOWN | Use of Cyanoacrylate in Healing and Pain in the Palatal Donor Site of Connective Tissue Grafts |
| NCT06806111 | Not specified | RECRUITING | Wound Healing and Patient-Reported Outcomes After Gingival Graft Harvesting From the Palate |
| NCT07450729 | Not specified | RECRUITING | GLUEPED2024: Study on the Use of Peripheral Venous Catheters in Pediatric Patients With Emergency Room Access. |
| NCT01111474 | Not specified | COMPLETED | Cyanoacrylate and Laser and Dentin Sensitivity |
| NCT01592578 | Not specified | UNKNOWN | The Research of the Evaluation of Clinical Procedures in Gastroesophageal Varices in Patients With Liver Cirrhosis |
| NCT02712242 | Not specified | COMPLETED | PRF for Accelerating Palatal Healing |
| NCT03273010 | Not specified | COMPLETED | The Use of Cyanoacrylate on Palatal Wound |
| NCT03392753 | Not specified | COMPLETED | Mechanochemical Ablation Compared to Cyanoacrylate Adhesive |
| NCT03835559 | Not specified | UNKNOWN | Cyanoacrylate Closure Versus Surgical Stripping for Incompetent Saphenous Veins |
| NCT03895476 | Not specified | COMPLETED | To Measure Pain Perception Following De-Epithelized Free Gingival Graft Harvesting |
| NCT03941938 | Not specified | UNKNOWN | ReAL Trial (Rectal Anastomotic seaL) |
| NCT04011371 | Not specified | COMPLETED | Cyanoacrylate Closure for Treatment of Venous Leg Ulcers |
| NCT04026906 | Not specified | COMPLETED | Skin Glue to Reduce Intravenous Catheter Failure in Children |
| NCT04403503 | Not specified | COMPLETED | The Influence of Tissue Adhesive to Palatal Donor Site Healing. |
| NCT04692805 | Not specified | UNKNOWN | EUS-guided PSE in Combination With EUS-guided Treatment of Varices for Patients With Portal Hypertension |
| NCT04714749 | Not specified | COMPLETED | Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue (ETUVVE) |
| NCT04854902 | Not specified | COMPLETED | Cyanoacrylate Use in Free Gingival Graft |
| NCT05246709 | Not specified | COMPLETED | Impact of Cyanoacrylate Glue on PICC Line Dressing Care |
| NCT05437744 | Not specified | UNKNOWN | Immediately Placed Implant Sealed With Platelets Rich Fibrin Versus Cyanoacrylate Glue |
| NCT06083259 | Not specified | COMPLETED | Cyanoacrylate With or Without Suture? |
| NCT06583226 | Not specified | COMPLETED | The Effect of Two Different Approaches on Palatal Donor Site |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.