Mepivacaine

Summary

Mepivacaine (CHEMBL1087) is an approved small-molecule local anaesthetic (ATC N01BB03); indicated across 4 conditions including osteoarthritis, hip and osteoarthritis, knee.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: N01BB03 (+1 more)
• Indications: 4 conditions
• Clinical trials: 40
• Chemistry: 246.35 Da · C15H22N2O

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1087
Name	Mepivacaine
Type	Small molecule
Max phase	4
FDA approved	yes
PubChem CID	4062
ChEBI	CHEBI:6759
ATC	N01BB03, N01BB53
Molecular formula	C15H22N2O
Molecular weight	246.35
InChIKey	INWLQCZOYSRPNW-UHFFFAOYSA-N

SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C

IUPAC name: N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide

ChEBI definition: A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.

Pharmacological roles (ChEBI): local anaesthetic, drug allergen.

Also known as: APF-135, Carboplyin dental, Dl-mepivacaine, Mepisv, Mepivacaina, Mepivacaine, Tevacaine, mepivacaine, MEPIVACAINE

Parent form; salt/anhydrous children: CHEMBL1200440

Patent coverage: 4,408 distinct patent families (16,273 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

4 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
osteoarthritis, hip	2	MONDO:0006629	EFO:1000786
osteoarthritis, knee	2	MONDO:0005416	EFO:0004616
compartment syndrome	1	MONDO:0004001	MONDO:0004001

1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 40.

Phase distribution

Phase	Trials
PHASE4	16
Not specified	13
PHASE3	5
PHASE1	3
PHASE2/PHASE3	1
PHASE1/PHASE2	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04454203	PHASE4	RECRUITING	Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension
NCT05425979	PHASE4	ENROLLING_BY_INVITATION	Mepivacaine Versus Bupivacaine Onset Time in Ultrasound-guided Ankle Blocks
NCT07239999	PHASE4	NOT_YET_RECRUITING	Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty
NCT01574807	PHASE4	COMPLETED	The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
NCT01981291	PHASE4	COMPLETED	Duration of Sciatic Nerve Block After Injection of Local Anesthetic In or Around the Nerve
NCT02110966	PHASE4	COMPLETED	Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis
NCT02162121	PHASE4	COMPLETED	Stimulating Catheter for Lumbar Plexus Block: Better Postoperative Analgesia?
NCT02384915	PHASE4	COMPLETED	Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy
NCT02980926	PHASE4	COMPLETED	Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty
NCT03390426	PHASE4	COMPLETED	Femoral Peri-arterial Local Anesthetic Injection Decreases Tourniquet Associated Ischemic Hypertension
NCT03948386	PHASE4	COMPLETED	3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
NCT04257682	PHASE4	UNKNOWN	Regional Anesthesia in Total Hip and Knee Arthroplasty
NCT05252117	PHASE4	UNKNOWN	Uterovaginal Plexus Block With Articaine for Intrauterine Device Placement Patients Who Are Indicated for the Use of Copper IUD as a Contraceptive Method Will be Invited to Participate in This Research.
NCT05980546	PHASE4	COMPLETED	Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty
NCT06047366	PHASE4	TERMINATED	Combination of Buffered Anesthetic to Treat Mandibular Molars
NCT06291727	PHASE4	COMPLETED	Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA
NCT05839548	PHASE3	ACTIVE_NOT_RECRUITING	Articaine Efficacy and Safety for 3 Years Old Children
NCT00825786	PHASE3	COMPLETED	Ultrasound Guided Supraclavicular Nerve Block
NCT01522534	PHASE3	TERMINATED	Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Morphine for Traumatic Severe Acute Pain in the Prehospital Setting
NCT02078063	PHASE3	COMPLETED	Analgesia for Insertion of Intrauterine Contraception
NCT03838874	PHASE2/PHASE3	COMPLETED	Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty
NCT05201313	PHASE3	COMPLETED	Efficacy and Safety of the Application of Local Anaesthetic in Spray to Repair of 1st- 2nd Perineal Lacerations
NCT01860417	PHASE1/PHASE2	COMPLETED	Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV)
NCT03365752	PHASE2	TERMINATED	Chloroprocaine Spinal for Outpatient Knee Surgery
NCT01032798	PHASE1	COMPLETED	Local Anesthetics New Formulations: From Development to Clinical Tests
NCT04113954	PHASE1	COMPLETED	Detecting Compartment Syndrome Pain in the Presence of Regional Anesthesia in Healthy Volunteers
NCT06005480	PHASE1	COMPLETED	Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers
NCT01485653	Not specified	COMPLETED	Dosage of Mepivacaine in Ultrasound Axillary Block
NCT01533545	Not specified	TERMINATED	Effect of Epinephrine on Systemic Absorption of Mepivacaine in Uremic Patients
NCT01701102	Not specified	COMPLETED	Study to Find Optimal Dose of Local Spinal Anesthetic (Mepivacaine) Combined With Narcotic (Fentanyl) For Knee Surgery
NCT02406703	Not specified	COMPLETED	The Impact of Chloroprocaine 3% for Ambulatory Foot Surgery on Perioperative Process Costs
NCT02584452	Not specified	COMPLETED	Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction
NCT02726620	Not specified	COMPLETED	Decision Support for Intraoperative Low Blood Pressure
NCT03942991	Not specified	UNKNOWN	Anesthetic Efficacy Of 4% ArtpharmaDent Versus 2% Mepecaine-L in Extraction of Lower First Primary Molars
NCT04822415	Not specified	COMPLETED	Anaesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine With Symptomatic Irreversible Pulpitis
NCT05728151	Not specified	COMPLETED	Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs
NCT05765682	Not specified	COMPLETED	Mepivacaine Vs. Bupivacaine Spinal for TKA
NCT06128590	Not specified	COMPLETED	Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain
NCT06172400	Not specified	UNKNOWN	Wide Awake Open Carpal Tunnel Release With or Without a Tourniquet
NCT06268912	Not specified	COMPLETED	Cryoanalgesia for Irreversible Pulpitis

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No CPIC/DPWG dosing guideline or drug-level clinical/variant annotations in PharmGKB for this molecule.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).