Mesterolone

Summary

Mesterolone (CHEMBL258918) is an approved small molecule (ATC G03BB01).

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: G03BB01
• Chemistry: 304.5 Da · C20H32O2

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL258918
Name	Mesterolone
Type	Small molecule
Max phase	4
FDA approved	no
PubChem CID	15020
ATC	G03BB01
Molecular formula	C20H32O2
Molecular weight	304.5
InChIKey	UXYRZJKIQKRJCF-TZPFWLJSSA-N

SMILES: C[C@H]1CC(=O)C[C@H]2[C@]1([C@H]3CC[C@]4([C@H]([C@@H]3CC2)CC[C@@H]4O)C)C

IUPAC name: (1S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-1,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

Also known as: Androviron, Mesterolona, Mesterolone, NSC-75054, Pro-viron, Proviron, SH 723, SH-723, Testiwop, 1alpha-methyldihydrotestosterone, MESTEROLONE

Patent coverage: 742 distinct patent families (2,485 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

Broader ChEMBL bioactivity targets: 2 (assay-derived). Sample: Androgen receptor, Sex hormone-binding globulin.

Bioactivity

ChEMBL activities: 1 potent at pChembl ≥ 5 of 2 total. Top 30 by potency (10 = 0.1 nM, 6 = 1 µM):

Target	pChembl	Type	Value	Unit	Activity ID
SHBG	9.6	Kd	0.25	nM	CHEMBL_ACT_2155751

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

0 indications (0 at ChEMBL trial phase 4).

Clinical trials

Total trials: 0.

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).