Metformin
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Also known as LA-6023Metformin extended releaseMetforminaMetformineNN-dimethylimidodicarbonimidic diamideSID11112469SID137275802DimethyldiguanideSID144212687SID174006543MeltforminMETFORMIN HYDROCHLORIDE
Summary
Metformin (CHEMBL1431) is an approved small-molecule hypoglycemic agent (ATC A10BA02) targeting SLC47A1 and SLC47A2; indicated across 157 conditions including diabetes mellitus and gestational diabetes; with CIViC clinical evidence for 5 variant-indication associations (e.g. EGFR Mutation in lung adenocarcinoma).
At a glance
- Status: Approved (max clinical phase 4)
- Modality: Small molecule
- ATC class: A10BA02
- Targets: 2 (SLC47A1, SLC47A2)
- Indications: 157 conditions
- Clinical trials: 1,702
- Precision-oncology evidence (CIViC): 5 variant–indication associations
- Chemistry: 129.16 Da · C4H11N5
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL1431 |
| Name | Metformin |
| Type | Small molecule |
| Max phase | 4 |
| FDA approved | yes |
| PubChem CID | 4091 |
| ChEBI | CHEBI:6801 |
| ATC | A10BA02 |
| Molecular formula | C4H11N5 |
| Molecular weight | 129.16 |
| InChIKey | XZWYZXLIPXDOLR-UHFFFAOYSA-N |
SMILES: CN(C)C(=N)N=C(N)N
IUPAC name: 3-(diaminomethylidene)-1,1-dimethylguanidine
ChEBI definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Pharmacological roles (ChEBI): hypoglycemic agent, geroprotector.
Other ChEBI roles (chemical / environmental): xenobiotic, environmental contaminant.
Also known as: LA-6023, Metformin, Metformin extended release, Metformina, Metformine, N, N-dimethylimidodicarbonimidic diamide, metformin, SID11112469, METFORMIN, SID137275802, Dimethyldiguanide
Parent form; salt/anhydrous children: CHEMBL1703, CHEMBL3094198
Patent coverage: 51,839 distinct patent families (167,749 SureChEMBL compound mentions), from 4 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.
Targets
Targets
Primary targets (GtoPdb curated mechanism): the Cancer dependency column is the DepMap CRISPR fitness signal (% of screened cell lines dependent on the target).
| Gene | Target | Action | pAffinity | Cancer dependency | UniProt |
|---|---|---|---|---|---|
| SLC47A1 | Multidrug and toxin extrusion | 0.5% | Q96FL8 | ||
| SLC47A2 | MATE2 | 0.6% | Q86VL8 |
Broader ChEMBL bioactivity targets: 4 (assay-derived). Sample: Prelamin-A/C, Ferritin light chain, Alpha-1A adrenergic receptor, Dipeptidyl peptidase 4.
Bioactivity
ChEMBL activities: 3 potent at pChembl ≥ 5 of 4 total. Top 30 by potency (10 = 0.1 nM, 6 = 1 µM):
| Target | pChembl | Type | Value | Unit | Activity ID |
|---|---|---|---|---|---|
| LMNA | 8.46 | Potency | 3.5 | nM | CHEMBL_ACT_3645602 |
| ADRA1A | 5.25 | AC50 | 5595 | nM | CHEMBL_ACT_25137679 |
| P02791 | 5.1 | Potency | 7943 | nM | CHEMBL_ACT_4461649 |
Target pathways
Aggregated over 2 target gene(s): SLC47A1, SLC47A2.
Top Reactome pathways
4 total, by targets touching each:
| Pathway | Targets | Genes |
|---|---|---|
| Transport of small molecules | 2 | SLC47A1, SLC47A2 |
| R-HSA-425366 | 2 | SLC47A1, SLC47A2 |
| SLC-mediated transmembrane transport | 2 | SLC47A1, SLC47A2 |
| SLC-mediated transport of organic cations | 2 | SLC47A1, SLC47A2 |
Dominant GO biological processes
| GO term | Targets |
|---|---|
| obsolete organic cation transport | 2 |
| transmembrane transport | 2 |
| xenobiotic detoxification by transmembrane export across the plasma membrane | 2 |
| proton transmembrane transport | 2 |
| xenobiotic transmembrane transport | 1 |
| putrescine transport | 1 |
| xenobiotic transport | 1 |
| amino acid import across plasma membrane | 1 |
| L-arginine import across plasma membrane | 1 |
| L-alpha-amino acid transmembrane transport | 1 |
| thiamine transmembrane transport | 1 |
| monoatomic cation transmembrane transport | 1 |
| L-arginine transmembrane transport | 1 |
Indications & clinical
Indications
157 indications (1 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| diabetes mellitus | 4 | MONDO:0005015 | EFO:0000400 |
| gestational diabetes | 3 | MONDO:0005406 | EFO:0004593 |
| metabolic syndrome X | 3 | MONDO:0011565 | EFO:0000195 |
| polycystic ovary syndrome | 3 | MONDO:0008487 | EFO:0000660 |
| obesity disorder | 3 | MONDO:0011122 | EFO:0001073 |
| peripheral arterial disease | 3 | MONDO:0005386 | EFO:0004265 |
| colorectal adenocarcinoma | 3 | MONDO:0005008 | EFO:0000365 |
| metabolic dysfunction-associated steatotic liver disease | 3 | MONDO:0013209 | EFO:0003095 |
| brain neoplasm | 3 | MONDO:0021211 | EFO:0003833 |
| fatty liver disease | 3 | MONDO:0004790 | HP:0001397 |
| infertility disorder | 3 | MONDO:0005047 | EFO:0000545 |
| metabolic disease | 3 | MONDO:0005066 | EFO:0000589 |
| psoriasis | 3 | MONDO:0005083 | EFO:0000676 |
| colorectal neoplasm | 3 | MONDO:0005335 | EFO:0004142 |
| schizoaffective disorder | 3 | MONDO:0005487 | EFO:0005411 |
| prediabetes syndrome | 3 | MONDO:0006920 | EFO:1001121 |
| metabolic dysfunction-associated steatohepatitis | 3 | MONDO:0007027 | EFO:1001249 |
| autosomal dominant polycystic kidney disease | 3 | MONDO:0004691 | EFO:1001496 |
| colorectal carcinoma | 3 | MONDO:0024331 | EFO:1001951 |
| hypertensive disorder | 3 | MONDO:0005044 | EFO:0000537 |
| glucose intolerance | 3 | MONDO:0001076 | EFO:0002546 |
| atherosclerosis | 3 | MONDO:0005311 | EFO:0003914 |
| endometrium neoplasm | 3 | MONDO:0021251 | MONDO:0011962 |
| severe acute respiratory syndrome | 3 | MONDO:0005091 | EFO:0000694 |
| coronary artery disorder | 3 | MONDO:0005010 | EFO:0001645 |
| hidradenitis suppurativa | 3 | MONDO:0006559 | EFO:1000710 |
| intermittent vascular claudication | 3 | MONDO:0005295 | EFO:0003876 |
| acute coronary syndrome | 3 | MONDO:0005542 | EFO:0005672 |
| type 1 diabetes mellitus | 3 | MONDO:0005147 | MONDO:0005147 |
| type 2 diabetes mellitus | 3 | MONDO:0005148 | MONDO:0005148 |
| osteoarthritis | 3 | MONDO:0005178 | MONDO:0005178 |
| migraine disorder | 3 | MONDO:0005277 | MONDO:0005277 |
| Huntington disease | 3 | MONDO:0007739 | MONDO:0007739 |
| muscular dystrophy | 3 | MONDO:0020121 | MONDO:0020121 |
| epilepsy | 3 | MONDO:0005027 | EFO:0000474 |
| ischemia reperfusion injury | 3 | MONDO:0005203 | EFO:0002687 |
| bipolar disorder | 3 | MONDO:0004985 | MONDO:0004985 |
| glaucoma | 3 | MONDO:0005041 | MONDO:0005041 |
| preeclampsia | 3 | MONDO:0005081 | EFO:0000668 |
| brain cancer | 3 | MONDO:0001657 | MONDO:0001657 |
| long COVID-19 | 3 | MONDO:0100233 | MONDO:0100233 |
| B-cell chronic lymphocytic leukemia | 2 | MONDO:0004948 | EFO:0000095 |
| breast carcinoma | 2 | MONDO:0004989 | EFO:0000305 |
| metastatic prostate carcinoma | 2 | MONDO:0004956 | EFO:0000196 |
| neoplasm | 2 | MONDO:0005070 | EFO:0000616 |
| prostate adenocarcinoma | 2 | MONDO:0005082 | EFO:0000673 |
| prostate carcinoma | 2 | MONDO:0005159 | EFO:0001663 |
| non-small cell lung carcinoma | 2 | MONDO:0005233 | EFO:0003060 |
| squamous cell carcinoma | 2 | MONDO:0005096 | EFO:0000707 |
| periodontitis | 2 | MONDO:0005076 | EFO:0000649 |
| adenocarcinoma | 2 | MONDO:0004970 | EFO:0000228 |
| pulmonary arterial hypertension | 2 | MONDO:0015924 | EFO:0001361 |
| metastatic melanoma | 2 | MONDO:0005191 | EFO:0002617 |
| rectal cancer | 2 | MONDO:0006519 | EFO:1000657 |
| head and neck squamous cell carcinoma | 2 | MONDO:0010150 | EFO:0000181 |
| chronic kidney disease | 2 | MONDO:0005300 | EFO:0003884 |
| diffuse large B-cell lymphoma | 2 | MONDO:0018905 | EFO:0000403 |
| atrial fibrillation | 2 | MONDO:0004981 | EFO:0000275 |
| glioblastoma | 2 | MONDO:0018177 | EFO:0000519 |
| hepatocellular carcinoma | 2 | MONDO:0007256 | EFO:0000182 |
| carcinoma | 2 | MONDO:0004993 | EFO:0000313 |
| rheumatoid arthritis | 2 | MONDO:0008383 | EFO:0000685 |
| melanoma | 2 | MONDO:0005105 | EFO:0000756 |
| ovarian carcinoma | 2 | MONDO:0005140 | EFO:0001075 |
| plasma cell myeloma | 2 | MONDO:0009693 | EFO:0001378 |
| cervical adenocarcinoma | 2 | MONDO:0005153 | EFO:0001416 |
| exocrine pancreatic carcinoma | 2 | MONDO:0005192 | EFO:0002618 |
| systolic heart failure | 2 | MONDO:0006993 | EFO:1001207 |
| hepatitis | 2 | MONDO:0002251 | HP:0012115 |
| chronic obstructive pulmonary disease | 2 | MONDO:0005002 | EFO:0000341 |
| lung adenocarcinoma | 2 | MONDO:0005061 | EFO:0000571 |
| small cell lung carcinoma | 2 | MONDO:0008433 | EFO:0000702 |
| esophageal squamous cell carcinoma | 2 | MONDO:0005580 | EFO:0005922 |
| minimally invasive lung adenocarcinoma | 2 | MONDO:0004991 | EFO:0000308 |
| lung large cell carcinoma | 2 | MONDO:0003050 | EFO:0003050 |
| angiosarcoma | 2 | MONDO:0016982 | EFO:0003968 |
| abdominal aortic aneurysm | 2 | MONDO:0005350 | EFO:0004214 |
| triple-negative breast carcinoma | 2 | MONDO:0005494 | EFO:0005537 |
| pancreatic neuroendocrine tumor | 2 | MONDO:0019954 | EFO:1000045 |
| neuroendocrine neoplasm | 2 | MONDO:0019496 | EFO:1001901 |
| blindness (disorder) | 2 | MONDO:0001941 | MONDO:0001941 |
| breast neoplasm | 2 | MONDO:0021100 | MONDO:0007254 |
| lung neoplasm | 2 | MONDO:0021117 | MONDO:0008903 |
| follicular lymphoma | 2 | MONDO:0018906 | MONDO:0018906 |
| oral cavity squamous cell carcinoma | 2 | MONDO:0004958 | EFO:0000199 |
| ulcerative colitis | 2 | MONDO:0005101 | EFO:0000729 |
| peripheral neuropathy | 2 | MONDO:0005244 | EFO:0003100 |
| burn | 2 | MONDO:0043519 | EFO:0009516 |
| intellectual disability | 2 | MONDO:0001071 | HP:0001249 |
| leprosy | 2 | MONDO:0005124 | EFO:0001054 |
| heart failure | 2 | MONDO:0005252 | EFO:0003144 |
| multiple sclerosis | 2 | MONDO:0005301 | MONDO:0005301 |
| fragile X syndrome | 2 | MONDO:0010383 | MONDO:0010383 |
| Bardet-Biedl syndrome | 2 | MONDO:0015229 | MONDO:0015229 |
| frontotemporal dementia | 2 | MONDO:0017276 | MONDO:0017276 |
| sex chromosome disorder of sex development | 2 | MONDO:0017975 | MONDO:0017975 |
| inflammatory bowel disease | 2 | MONDO:0005265 | EFO:0003767 |
| fibromyalgia | 2 | MONDO:0005546 | EFO:0005687 |
| malignant pancreatic neoplasm | 2 | MONDO:0009831 | EFO:1000359 |
| cerebral palsy | 2 | MONDO:0006497 | EFO:1000632 |
| Parkinson disease | 2 | MONDO:0005180 | MONDO:0005180 |
| sarcoidosis | 2 | MONDO:0019338 | MONDO:0019338 |
| endocrine gland neoplasm | 2 | MONDO:0002082 | EFO:0003769 |
| acne | 2 | MONDO:0011438 | EFO:0003894 |
| oral mucosa leukoplakia | 2 | MONDO:0004844 | MONDO:0004844 |
| HIV infectious disease | 1 | MONDO:0005109 | EFO:0000764 |
| acute lymphoblastic leukemia | 1 | MONDO:0004967 | EFO:0000220 |
| neuralgia | 1 | MONDO:0021667 | EFO:0005762 |
| head and neck cancer | 1 | MONDO:0005627 | EFO:0006859 |
| major depressive disorder | 1 | MONDO:0002009 | MONDO:0002009 |
| breast carcinoma in situ | 1 | MONDO:0004658 | MONDO:0004658 |
| diabetes insipidus | 1 | MONDO:0004782 | MONDO:0004782 |
| colonic neoplasm | 1 | MONDO:0005401 | MONDO:0021063 |
| obstructive sleep apnea syndrome | 1 | MONDO:0007147 | EFO:0003918 |
| generalized anxiety disorder | 1 | MONDO:0001942 | EFO:1001892 |
| liver disorder | 1 | MONDO:0005154 | HP:0002910 |
| malaria | 1 | MONDO:0005136 | EFO:0001068 |
| Duchenne muscular dystrophy | 1 | MONDO:0010679 | MONDO:0010679 |
| sickle cell disease | 1 | MONDO:0011382 | MONDO:0011382 |
| tuberculosis | 1 | MONDO:0018076 | MONDO:0018076 |
| Li-Fraumeni syndrome | 1 | MONDO:0018875 | MONDO:0018875 |
| alopecia areata | 1 | MONDO:0005340 | EFO:0004192 |
| focal segmental glomerulosclerosis | 1 | MONDO:0100313 | EFO:0004236 |
| diabetic retinopathy | 0 | MONDO:0005266 | EFO:0003770 |
| Barrett esophagus | 0 | MONDO:0013662 | EFO:0000280 |
| cardiovascular disorder | 0 | MONDO:0004995 | EFO:0000319 |
| primary progressive multiple sclerosis | 0 | MONDO:0000451 | EFO:0008520 |
| secondary progressive multiple sclerosis | 0 | MONDO:0000450 | EFO:0008522 |
29 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 1,702.
Phase distribution
(phase/status distribution below is over 1,600 sampled trials of the 1,702 total).
| Phase | Trials |
|---|---|
| PHASE4 | 378 |
| PHASE3 | 339 |
| PHASE2 | 317 |
| PHASE1 | 276 |
| Not specified | 150 |
| PHASE2/PHASE3 | 52 |
| EARLY_PHASE1 | 49 |
| PHASE1/PHASE2 | 39 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03570632 | PHASE4 | ACTIVE_NOT_RECRUITING | Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus |
| NCT03603912 | PHASE4 | ACTIVE_NOT_RECRUITING | Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) |
| NCT04407650 | PHASE4 | ACTIVE_NOT_RECRUITING | Ursodeoxycholic Acid vs Metformin in Gestational Diabetes Mellitus |
| NCT05120505 | PHASE4 | RECRUITING | Metformin in Children With Fragile X Syndrome |
| NCT05366868 | PHASE4 | ACTIVE_NOT_RECRUITING | Durable Effect of Imeglimin on the Glycemic Control in Patients With Type 2 Diabetes Mellitus |
| NCT05680805 | PHASE4 | ACTIVE_NOT_RECRUITING | Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS |
| NCT05744479 | PHASE4 | RECRUITING | Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability |
| NCT06215976 | PHASE4 | RECRUITING | The Nephroprotective Effect of Metformin With Cisplatin in Bladder Cancer |
| NCT06296836 | PHASE4 | RECRUITING | Effect of Continuing Versus Holding Metformin During Hospitalizations. |
| NCT06439758 | PHASE4 | NOT_YET_RECRUITING | Effects of First-Line Oral Hypoglycemics in Bone Markers of Treatment Naïve Saudi Adults With Type 2 Diabetes |
| NCT06445946 | PHASE4 | RECRUITING | DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes |
| NCT06449235 | PHASE4 | NOT_YET_RECRUITING | Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh |
| NCT06449833 | PHASE4 | RECRUITING | Effect of Henagliflozein on Hepatic Fat Content in Patients With T2DM and NAFLD |
| NCT06638671 | PHASE4 | ACTIVE_NOT_RECRUITING | Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity |
| NCT06682351 | PHASE4 | NOT_YET_RECRUITING | Heterogeneity of Diabetes: Integrated Muli-Omics to Identify Physiologic Subphenotypes and Evaluate Targeted Prevention |
| NCT06707012 | PHASE4 | RECRUITING | Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients |
| NCT06742710 | PHASE4 | RECRUITING | Liraglutide Treatment in Obese Infertile PCOS Women |
| NCT06781775 | PHASE4 | RECRUITING | GDM: Insulin with or Without Metformin? |
| NCT06829238 | PHASE4 | RECRUITING | Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use |
| NCT06846411 | PHASE4 | RECRUITING | The EMPA-FIT Study |
| NCT06851962 | PHASE4 | ACTIVE_NOT_RECRUITING | Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. |
| NCT06856369 | PHASE4 | ACTIVE_NOT_RECRUITING | Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis |
| NCT06862739 | PHASE4 | RECRUITING | Glycemic Control With Triple Pathway Approach Through Empagliflozin, Linagliptin and Metformin Combination |
| NCT06888050 | PHASE4 | RECRUITING | Efficacy and Safety of Henagliflozin Proline and Metformin Hydrochloride Extended-release Tablets (Ⅰ) Versus Metformin Tablets in Patients With New-onset Type 2 Diabetes: a Multicenter, Randomized Controlled Study |
| NCT06937294 | PHASE4 | RECRUITING | Metformin in Post Chronic Pancreatitis Diabetes Mellitus |
| NCT06959784 | PHASE4 | ENROLLING_BY_INVITATION | Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study) |
| NCT06972732 | PHASE4 | RECRUITING | A Phase IV Clinical Trial to Compare the Efficacy and Safety of Metformin+Sodium-Glucose Cotransporter 2 Inhibitor(SGLT2-i)+Thiazolidinedione (TZD) in Patients With Type 2 Diabetes |
| NCT07001878 | PHASE4 | RECRUITING | Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis |
| NCT07019012 | PHASE4 | RECRUITING | Cofrogliptin Once Every 2 Weeks as Add-on Therapy to Metformin and Dapagliflozin Versus Daily Linagliptin in Patients With Type 2 Diabetes. |
| NCT07173712 | PHASE4 | NOT_YET_RECRUITING | Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes |
| NCT07244003 | PHASE4 | RECRUITING | Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control |
| NCT07254572 | PHASE4 | RECRUITING | Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes |
| NCT07272967 | PHASE4 | NOT_YET_RECRUITING | Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury |
| NCT07442006 | PHASE4 | RECRUITING | Glycemic Variability of Combination Therapies in T2DM |
| NCT07452913 | PHASE4 | ENROLLING_BY_INVITATION | Metformin, Empagliflozin With Sitagliptin vs Linagliptin in Type 2 Diabetes |
| NCT07485764 | PHASE4 | NOT_YET_RECRUITING | Metformin Combined With Secukinumab for Moderate-to-Severe Plaque Psoriasis in Overweight or Obese Chinese Patients |
| NCT00108615 | PHASE4 | COMPLETED | Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance |
| NCT00118937 | PHASE4 | COMPLETED | Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet |
| NCT00118950 | PHASE4 | COMPLETED | Effect of Metformin Versus Repaglinide Treatment in Non-Obese Type 2 Diabetic Patients Uncontrolled by Diet |
| NCT00118963 | PHASE4 | COMPLETED | Effect of Repaglinide Versus Metformin Treatment in Non-Obese Patients With Type-2-Diabetes |
Clinical evidence (CIViC)
Variant × indication × effect (5 predictive associations from 5 curated evidence items):
| Variant | Indication | Effect | Therapy | Level | CIViC |
|---|---|---|---|---|---|
| EGFR Mutation | Lung Adenocarcinoma | Sensitivity/Response | EGFR Tyrosine Kinase Inhibitor Therapy + Metformin | CIViC B | EID12074 |
| IGF1R Overexpression | Breast Cancer | Sensitivity/Response | Exemestane + Metformin | CIViC B | EID10138 |
| KRAS Mutation | Colorectal Cancer | Sensitivity/Response | Metformin | CIViC B | EID8301 |
| SDHB Mutation | Hereditary Renal Cell Carcinoma | Sensitivity/Response | Vandetanib + Metformin | CIViC B | EID7959 |
| NRAS Mutation | Cancer | Sensitivity/Response | Metformin + Trametinib | CIViC D | EID1230 |
Pharmacology
Pharmacogenomics
No CPIC/DPWG dosing guideline, but PharmGKB curates 30 clinical and 162 variant annotation(s) for this drug (gene-keyed; see PharmGKB).
Related molecules
Related molecules
Molecules sharing ≥1 of this drug’s curated primary targets, merged from two biobtree sources and ranked by shared-target count, then clinical phase: ChEMBL clinical-stage candidates (development phase ≥2) and PubChem drug-class bioactivity (approved / known drugs acting on the target). Deduplicated by drug name; the drug’s own salt forms are excluded. Note: for a drug with few primary targets a shared-target match can reflect off-target / promiscuous binding rather than the same therapeutic mechanism — the phase ordering surfaces bona-fide therapeutics first.
68 molecules share ≥1 primary target. Top 60 by shared-target count:
| Molecule | Source | Status | Shared targets |
|---|---|---|---|
| BUSPIRONE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| CARVEDILOL | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| CHLORHEXIDINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| CIMETIDINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| DIHYDROERGOTAMINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| DIPYRIDAMOLE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| DISOPYRAMIDE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| DOMPERIDONE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| EPINASTINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| ETHINYL ESTRADIOL | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| FAMOTIDINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| IMATINIB | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| IMIPRAMINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| IRINOTECAN | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| MITOXANTRONE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| ONDANSETRON | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| ORPHENADRINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| PANTOPRAZOLE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| PENTAMIDINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| PRAZOSIN | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| QUINIDINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| RIMANTADINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| RISPERIDONE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| RITONAVIR | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| TOPOTECAN | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| TUBOCURARINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| VECURONIUM BROMIDE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| ZAFIRLUKAST | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1, SLC47A2 |
| BITHIONOL | ChEMBL | Phase 4 (approved) | SLC47A1, SLC47A2 |
| DABIGATRAN | ChEMBL + PubChem | Phase 3 (approved) | SLC47A1, SLC47A2 |
| CAMOSTAT | ChEMBL | Phase 3 | SLC47A1, SLC47A2 |
| GABEXATE | ChEMBL | Phase 3 | SLC47A1, SLC47A2 |
| INDINAVIR | ChEMBL | Phase 3 | SLC47A1, SLC47A2 |
| NIFEKALANT | ChEMBL | Phase 3 | SLC47A1, SLC47A2 |
| Aripiprazole | PubChem | Approved | SLC47A1, SLC47A2 |
| Pimozide | PubChem | Approved | SLC47A1, SLC47A2 |
| AMANTADINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1 |
| CLONIDINE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1 |
| SPIRONOLACTONE | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1 |
| SUMATRIPTAN | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1 |
| TELMISARTAN | ChEMBL + PubChem | Phase 4 (approved) | SLC47A1 |
| ASTEMIZOLE | ChEMBL | Phase 4 (approved) | SLC47A1 |
| GRANISETRON | ChEMBL | Phase 4 (approved) | SLC47A1 |
| LEVOFLOXACIN | ChEMBL | Phase 4 (approved) | SLC47A1 |
| MARAVIROC | ChEMBL | Phase 4 (approved) | SLC47A1 |
| NOSCAPINE | ChEMBL | Phase 4 (approved) | SLC47A1 |
| RANITIDINE | ChEMBL | Phase 4 (approved) | SLC47A1 |
| TACRINE | ChEMBL | Phase 4 (approved) | SLC47A1 |
| CORTISONE | ChEMBL + PubChem | Phase 3 (approved) | SLC47A1 |
| AFIMETORAN | ChEMBL | Phase 2 | SLC47A2 |
| azacitidine | PubChem | Approved | SLC47A1 |
| Cetirizine | PubChem | Approved | SLC47A1 |
| Ciclopirox | PubChem | Approved | SLC47A1 |
| Dexamethasone | PubChem | Approved | SLC47A1 |
| Diclofenac | PubChem | Approved | SLC47A1 |
| Enalapril | PubChem | Approved | SLC47A1 |
| Erythromycin | PubChem | Approved | SLC47A1 |
| Furosemide | PubChem | Approved | SLC47A1 |
| Indomethacin | PubChem | Approved | SLC47A1 |
| Irbesartan | PubChem | Approved | SLC47A1 |
Related Atlas pages
- Genes: SLC47A1, SLC47A2
- Diseases: diabetes mellitus, gestational diabetes, metabolic syndrome X, polycystic ovary syndrome, obesity disorder, peripheral arterial disease, colorectal adenocarcinoma, metabolic dysfunction-associated steatotic liver disease, brain neoplasm, fatty liver disease, infertility disorder, metabolic disease, psoriasis, colorectal neoplasm, schizoaffective disorder, prediabetes syndrome, metabolic dysfunction-associated steatohepatitis, autosomal dominant polycystic kidney disease, colorectal carcinoma, hypertensive disorder, glucose intolerance, atherosclerosis, endometrium neoplasm, severe acute respiratory syndrome, coronary artery disorder, hidradenitis suppurativa, intermittent vascular claudication, acute coronary syndrome, type 1 diabetes mellitus, type 2 diabetes mellitus, osteoarthritis, migraine disorder, Huntington disease, muscular dystrophy, epilepsy, ischemia reperfusion injury, bipolar disorder, glaucoma, preeclampsia, brain cancer, long COVID-19, lung adenocarcinoma, breast carcinoma, hereditary renal cell carcinoma, cancer
- Drugs: Buspirone, Carvedilol, Chlorhexidine, Cimetidine, Dihydroergotamine, Dipyridamole, Disopyramide, Domperidone, Epinastine, Ethinyl Estradiol, Famotidine, Imatinib, Imipramine, Irinotecan, Mitoxantrone, Ondansetron, Orphenadrine, Pantoprazole, Pentamidine, Prazosin, Quinidine, Rimantadine, Risperidone, Ritonavir, Topotecan, Tubocurarine, Vecuronium Bromide, Zafirlukast, Bithionol, Dabigatran, Camostat, Gabexate, Nifekalant, Aripiprazole, Pimozide, Amantadine, Clonidine, Spironolactone, Sumatriptan, Telmisartan, Astemizole, Granisetron, Levofloxacin, Maraviroc, Noscapine, Ranitidine, Tacrine, Cortisone, azacitidine, Cetirizine, Ciclopirox, Dexamethasone, Diclofenac, Enalapril, Erythromycin, Furosemide, Indomethacin, Irbesartan