Milk Thistle
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Also known as 822i9lej7sBlessed milk-thistle wholeBlessed milkthistle wholeCardui mariae fructusCarduus lactifolius wholeCarduus marianusCarduus marianus seedCarduus versicolor wholeFruit of silybum marianumHoly thistle seedLady's thistle seedMariana lactea wholeMariana mariana seedMary's thistle seedMilk thistle fruitMilk thistle seedMilk thistle silymarinMilk thistle wholeShuifeiji
Summary
Milk Thistle (CHEMBL2108623) is a phase-3 clinical-stage unknown; indicated across 9 conditions including obesity disorder and chronic kidney disease.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Unknown
- Indications: 9 conditions
- Clinical trials: 5
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL2108623 |
| Name | Milk Thistle |
| Type | Unknown |
| Max phase | 3 |
Also known as: 822i9lej7s, Blessed milk-thistle whole, Blessed milkthistle whole, Cardui mariae fructus, Carduus lactifolius whole, Carduus marianus, Carduus marianus seed, Carduus versicolor whole, Fruit of silybum marianum, Holy thistle seed, Lady’s thistle seed, Mariana lactea whole
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
9 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| obesity disorder | 3 | MONDO:0011122 | EFO:0001073 |
| chronic kidney disease | 2 | MONDO:0005300 | EFO:0003884 |
| diabetic kidney disease | 2 | MONDO:0005016 | EFO:0000401 |
| pathological gambling | 2 | MONDO:0011662 | EFO:0004699 |
| chronic hepatitis C virus infection | 2 | MONDO:0005354 | EFO:0004220 |
| metabolic dysfunction-associated steatotic liver disease | 2 | MONDO:0013209 | EFO:0003095 |
| trichotillomania | 2 | MONDO:0013189 | MONDO:0013189 |
| HIV infectious disease | 1 | MONDO:0005109 | EFO:0000764 |
| colonic neoplasm | 1 | MONDO:0005401 | MONDO:0021063 |
Clinical trials
Total trials: 5.
Phase distribution
| Phase | Trials |
|---|---|
| PHASE2 | 4 |
| Not specified | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02337634 | PHASE2 | COMPLETED | Milk Thistle in Pathological Gambling |
| NCT02473913 | PHASE2 | COMPLETED | Milk Thistle in Trichotillomania in Children and Adults |
| NCT02775448 | PHASE2 | TERMINATED | Dose-response Study of Carduus Marianus in Centesimal Scale for Dyslipidemia in Climacteric Overweighed or Obese Women. |
| NCT02843451 | PHASE2 | WITHDRAWN | Milk Thistle in Body Dysmorphic Disorder |
| NCT02404701 | Not specified | COMPLETED | Effect of Over-the-counter Dietary Supplements on Kidney Stone Risk |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: obesity disorder