Nitrous Acid

Summary

Nitrous Acid (CHEMBL1161681) is an approved small molecule; indicated across 1 condition including cardiac arrest.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• Indications: 1 condition
• Clinical trials: 39
• Chemistry: 47.014 Da · HNO2

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1161681
Name	Nitrous Acid
Type	Small molecule
Max phase	4
FDA approved	no
PubChem CID	24529
ChEBI	CHEBI:25567
Molecular formula	HNO2
Molecular weight	47.014
InChIKey	IOVCWXUNBOPUCH-UHFFFAOYSA-N

SMILES: N(=O)O

IUPAC name: nitrous acid

Also known as: Nitrous acid, Nitrous acid anion, nitrite, nitrite ion, Nitrite, NITROUS ACID, Sodium Nitrite

Parent form; salt/anhydrous children: CHEMBL93268, CHEMBL3186418

Patent coverage: 138,518 distinct patent families (286,808 SureChEMBL compound mentions), from 3 matched compound structure(s). One matched structure accounts for 286,467 (100%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

Broader ChEMBL bioactivity targets: 3 (assay-derived). Sample: Carbonic anhydrase 2, Carbonic anhydrase 13, Carbonic anhydrase 1.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

1 indication (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
cardiac arrest	1	MONDO:0000745	EFO:0009492

Clinical trials

Total trials: 39.

Phase distribution

Phase	Trials
PHASE2	18
PHASE1	9
Not specified	5
PHASE1/PHASE2	3
PHASE2/PHASE3	2
PHASE4	1
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02463357	PHASE4	COMPLETED	Three New Ideas to Protect Special Forces From the Stress of High Altitude
NCT01388504	PHASE2/PHASE3	COMPLETED	Nitrites in Acute Myocardial Infarction
NCT03331146	PHASE3	WITHDRAWN	Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass
NCT03452917	PHASE2/PHASE3	COMPLETED	Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest
NCT00048477	PHASE2	COMPLETED	Effects of Nitrite on Blood Vessel Dilation in Normal Volunteers
NCT00873015	PHASE2	COMPLETED	Safety and Pharmacokinetic Evaluation of Nitrite for Prevention of Cerebral Vasospasm
NCT00924118	PHASE2	COMPLETED	Sodium Nitrite in Acute Myocardial Infarction
NCT01098409	PHASE2	UNKNOWN	Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery
NCT01401517	PHASE2	COMPLETED	Phase IIa: Safety, PK, & Tolerability of Sodium Nitrite in Patients With Peripheral Arterial Disease-SONIC
NCT01431313	PHASE2	COMPLETED	Inhaled Nitrite in Subjects With Pulmonary Hypertension
NCT01584453	PHASE2	COMPLETED	Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction
NCT01715883	PHASE2	TERMINATED	Sodium Nitrite in Lung Transplant Patients to Minimize the Risk of Pulmonary Graft Dysfunction
NCT01932606	PHASE2	COMPLETED	Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction
NCT02022670	PHASE1/PHASE2	COMPLETED	Sodium Nitrite to Treat Arterial Aging
NCT02176837	PHASE2	TERMINATED	Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage
NCT02412852	PHASE2	COMPLETED	A Phase 2a Study to Assess Safety & Pharmacokinetics of Sustained Release Sodium Nitrite in Patients With Diabetic Pain
NCT02433977	PHASE2	COMPLETED	The Effects of NOx and Conjugated Linoleic Acid on Asthmatics
NCT02694393	PHASE1/PHASE2	TERMINATED	Inhaled Sodium Nitrite as an Antimicrobial for Cystic Fibrosis
NCT02713126	PHASE2	COMPLETED	Inorganic Nitrite to Amplify the Benefits and Tolerability of Exercise Training in Heart Failure With Preserved Ejection Fraction (HFpEF) (INABLE-Training)
NCT02863068	PHASE2	TERMINATED	Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers
NCT02918552	PHASE2	COMPLETED	Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction
NCT03015402	PHASE2	COMPLETED	Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction
NCT04001283	PHASE2	UNKNOWN	Nitrite Effects on Cardiac Muscle in CABG
NCT04354051	PHASE1/PHASE2	COMPLETED	The Nitrite and Coronary Flow Study
NCT04401527	PHASE2	WITHDRAWN	Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite
NCT00095472	PHASE1	COMPLETED	Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease
NCT00102271	PHASE1	COMPLETED	Nitrite Infusion Studies
NCT00103025	PHASE1	COMPLETED	Nitrite Infusion in Healthy Volunteers
NCT00105222	PHASE1	TERMINATED	Effect of Nitrite on Exercise Physiology and Metabolism
NCT01178359	PHASE1	COMPLETED	Pilot Study of Sodium Nitrite in Resuscitated Cardiac Arrest Patients
NCT02527837	PHASE1	UNKNOWN	The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Hypertensive Versus Healthy Subjects
NCT02987088	PHASE1	COMPLETED	Phase 1 Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest
NCT03077763	PHASE1	UNKNOWN	The Haem and Nitrite Study - The Effects of Haemoglobin NO-blockade on Nitrite-induced Forearm Vessel Dilatation
NCT04289558	PHASE1	WITHDRAWN	Nitrite Infusion in Children With Malaria
NCT02022176	Not specified	COMPLETED	Modulation of Metabolic Rate by Inorganic Nitrate
NCT02393742	Not specified	COMPLETED	Nitrite Supplementation for Improving Physiological Function in Older Adults
NCT02888561	Not specified	UNKNOWN	Haemodynamic Effects of Dobutamine and Nitrite in LV Dysfunction
NCT03625596	Not specified	COMPLETED	Nutritional Supplements and Nitric Oxide Bioactivity
NCT04239482	Not specified	TERMINATED	Nutritional Supplementation and Insulin Sensitivity

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).