Piperonyl Butoxide

Summary

Piperonyl Butoxide (CHEMBL1201131) is an approved small-molecule pesticide synergist.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• Chemistry: 338.4 Da · C19H30O5

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1201131
Name	Piperonyl Butoxide
Type	Small molecule
Max phase	4
FDA approved	no
PubChem CID	5794
ChEBI	CHEBI:32687
Molecular formula	C19H30O5
Molecular weight	338.4
InChIKey	FIPWRIJSWJWJAI-UHFFFAOYSA-N

SMILES: CCCCOCCOCCOCC1=CC2=C(C=C1CCC)OCO2

IUPAC name: 5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole

Pharmacological roles (ChEBI): pesticide synergist.

Also known as: NSC-8401, Piperonyl butoxide, Piperonyl butoxide technical, SID17389754, PIPERONYL BUTOXIDE, SID144214047, SID144204585, SID170464741

Patent coverage: 13,982 distinct patent families (36,444 SureChEMBL compound mentions), from 2 matched compound structure(s). One matched structure accounts for 36,361 (100%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

Broader ChEMBL bioactivity targets: 3 (assay-derived). Sample: Thyrotropin receptor, Cytochrome P450 3A4, Aldehyde dehydrogenase 1A1.

Bioactivity

ChEMBL activities: 5 potent at pChembl ≥ 5 of 7 total. Top 100 by potency (10 = 0.1 nM, 6 = 1 µM):

Target	pChembl	Type	Value	Unit	Activity ID
CYP3A4	6.3	Potency	501.2	nM	CHEMBL_ACT_5001792
CYP3A4	6.3	Potency	501.2	nM	CHEMBL_ACT_5066653
CYP3A4	5.52	IC50	3000	nM	CHEMBL_ACT_17706609
CYP3A4	5.52	IC50	3000	nM	CHEMBL_ACT_17707405
ALDH1A1	5	Potency	10000	nM	CHEMBL_ACT_4144268

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

0 indication records carry no mapped disease name (EFO/MeSH-only); none shown.

Clinical trials

Total trials: 0.

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).