Poliglusam
drugOn this page
Also known as ChitosanFEMA NO. 4946
Summary
Poliglusam (CHEMBL2108133) is a phase-3 clinical-stage small molecule; indicated across 7 conditions including breast neoplasm and pulpitis.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Small molecule
- Indications: 7 conditions
- Clinical trials: 36
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL2108133 |
| Name | Poliglusam |
| Type | Small molecule |
| Max phase | 3 |
Also known as: Chitosan, FEMA NO. 4946, Poliglusam, POLIGLUSAM
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
7 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| breast neoplasm | 3 | MONDO:0021100 | MONDO:0007254 |
| pulpitis | 2 | MONDO:0006937 | EFO:1001139 |
| oral candidiasis | 1 | MONDO:0005886 | EFO:0007406 |
| cirrhosis of liver | 0 | MONDO:0005155 | EFO:0001422 |
3 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 36.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 22 |
| PHASE1 | 4 |
| PHASE4 | 3 |
| PHASE3 | 3 |
| PHASE2/PHASE3 | 1 |
| PHASE2 | 1 |
| PHASE1/PHASE2 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06513039 | PHASE4 | RECRUITING | Evaluation of Erythropoietin on Alveolar Ridge Preservation |
| NCT02323451 | PHASE4 | UNKNOWN | Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) |
| NCT05661708 | PHASE4 | COMPLETED | Use of Chitosan Powder in Loop Electrosurgical Excision Procedure |
| NCT02081885 | PHASE3 | COMPLETED | Tricalcium Phosphate and Chitosan as Bone Regenerator Versus Autologous Graft in Surgery for Mandibular Fracture |
| NCT02591017 | PHASE3 | TERMINATED | Comparison of Oral Morphine Versus Nasal Ketamine Spray With Chitosan in Cancer Pain Outpatients |
| NCT02789033 | PHASE3 | COMPLETED | Efficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot Ulcers |
| NCT03719261 | PHASE2/PHASE3 | UNKNOWN | Assessment of Pain and Antibacterial Activity of Chitosan Versus Sodium Hypochlorite as Irrigant in Infected Canal |
| NCT00454831 | PHASE2 | COMPLETED | Efficacy and Safety of HEP-40 Chitosan for Mild to Moderately Elevated Cholesterol |
| NCT03712371 | PHASE1/PHASE2 | TERMINATED | Study of Chitosan for Pharmacologic Manipulation of AGE Levels in Prostate Cancer Patients |
| NCT06782087 | PHASE1 | ENROLLING_BY_INVITATION | A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching Agent |
| NCT06072716 | PHASE1 | COMPLETED | The Anti-fungal Effect of Miconazol Versus Miconazol-Loaded Chitosan Nanoparticles |
| NCT06175676 | PHASE1 | COMPLETED | Safety and Efficacy of Thermosensitive Hydroxybutyl Chitosan and 5-fluorouracil Assisted Endoscopic Dacryocystorhinostomy in the Treatment of Chronic Dacryocystitis |
| NCT06525363 | PHASE1 | COMPLETED | Clinical Assessment of Chitosan Nanoparticles on Periodontal Problems Post Steroidal Inhalation in Asthmatic Patients: Phase I Trial |
| NCT06457360 | EARLY_PHASE1 | COMPLETED | Comparison of Chitosan, Ankaferd and Tranexamic Acid in Dental Extraction in Liver Pre-Transplant Children |
| NCT06491992 | Not specified | RECRUITING | Chitosan Phonophresis on Cervical IN Smartphone Addicted Users |
| NCT06714695 | Not specified | RECRUITING | A Crossover Clinical Study to Evaluate the Effect of Chitosan Mouthwash on Recurrence of Black Stains in Pediatric Patients |
| NCT06755528 | Not specified | NOT_YET_RECRUITING | Effect of Shockwaves on Fallopian Tubes Adhesion |
| NCT06777303 | Not specified | ACTIVE_NOT_RECRUITING | Efficacy of Nano-Curcumin and Nano-Hyaluronic Acid as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis |
| NCT06823310 | Not specified | ACTIVE_NOT_RECRUITING | Antibiofilm Activity of Chitosan Nanoparticles Incorporated Into Clear Aligners |
| NCT07269093 | Not specified | RECRUITING | Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil |
| NCT07323433 | Not specified | RECRUITING | Efficacy of a Chitosan Dressing in Pulpotomy of Immature Permanent Teeth |
| NCT07482553 | Not specified | NOT_YET_RECRUITING | Antibiofilm Activity of Chitosan Nanoparticles Against Uropathogenic Escherichia Coli |
| NCT07544004 | Not specified | ENROLLING_BY_INVITATION | Chitosan Phonophoresis With Recurrent Hamstring Strain in Athletes |
| NCT01770470 | Not specified | COMPLETED | Chitosan Chewing Gum Study in Dialysis Patients |
| NCT03421717 | Not specified | COMPLETED | The Effect of Peri-implant Surgery and Chair-side Supportive Post Surgical Peri-implant Therapy |
| NCT03724266 | Not specified | UNKNOWN | Effect of Using Nanochitosan Versus Calcium Hydroxide as Disinfectant on Pain and Apical Bone Healing |
| NCT03907111 | Not specified | COMPLETED | Compare the Hemostatic Effectiveness of Chitosan Gauze With Traditional Gauze on Open Wound on 10 Participants. |
| NCT04551365 | Not specified | COMPLETED | MicroFIBERgut: Effects of Lifestyle Changes and Chitosan on Gut Microbiota and Weight Management |
| NCT04783233 | Not specified | WITHDRAWN | Chitogel CSK-4 Gel as Packing in Tympanoplasty Surgery |
| NCT04884919 | Not specified | UNKNOWN | Develop the First Aid Medical Supplies for Hemostasis and Bacteriostasis With Clinical Trial |
| NCT05212311 | Not specified | COMPLETED | Effect of Chitosan Phonophoresis On Cubital Tunnel Syndrome |
| NCT06127069 | Not specified | COMPLETED | Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device |
| NCT06506526 | Not specified | COMPLETED | Evaluation of Chitosan as Irrigating Solution for Pulpectomy in Non-Vital Primary Teeth |
| NCT06758440 | Not specified | COMPLETED | Effectiveness of Hydroxyapatite Reinforced Chitosan Hydrogel in Modulation of Osseointegration |
| NCT07072546 | Not specified | COMPLETED | Chitosan and i-PRF in Palatal Wound Healing |
| NCT07472465 | Not specified | COMPLETED | Comparing Chitosan Sponge With Hydrocolloid as Dressing for Split-thickness Skin Graft Donor Site Wounds |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: breast neoplasm