POLYETHYLENE GLYCOL 4000

Summary

Polyethylene Glycol 4000 (CHEMBL2108780) is a phase-3 clinical-stage small molecule; indicated across 3 conditions including constipation disorder and diabetes mellitus.

At a glance

• Status: Max clinical phase 3 (not approved)
• Modality: Small molecule
• Indications: 3 conditions
• Clinical trials: 7

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL2108780
Name	POLYETHYLENE GLYCOL 4000
Type	Small molecule
Max phase	3

Also known as: Carbowax 4000, Dulcobalance, Forlax, Idrolax, Lipoxol 4000 med, Macrogol 4000, Peg 4000, Peg-85, Peg-90, Pluracare e 4000, Polyethylene glycol 4000, Polyglykol 4000

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

3 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
constipation disorder	3	MONDO:0002203	HP:0002019
diabetes mellitus	3	MONDO:0005015	EFO:0000400
dry eye syndrome	3	MONDO:0006733	EFO:1000906

Clinical trials

Total trials: 7.

Phase distribution

Phase	Trials
PHASE4	5
PHASE3	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00603681	PHASE4	COMPLETED	Comparison of PEG Solutions With and Without Electrolytes in the Treatment of Constipation
NCT01875744	PHASE4	COMPLETED	Polyethylene Glycol for Childhood Constipation
NCT02073552	PHASE4	COMPLETED	Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid.
NCT02751411	PHASE4	COMPLETED	Effectiveness & Safety of Promelaxin® Microenemas Against Macrogol 4000 P.O. in Chronic Constipation in Children 6-48 Months
NCT03742232	PHASE4	COMPLETED	Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen.
NCT01330381	PHASE3	COMPLETED	Prucalopride in Pediatric Subjects With Functional Constipation
NCT03639142	PHASE3	UNKNOWN	Dried Plums (Prunes) vs. Polyethylene Glycol 4000 for Treatment of Functional Constipation in Children

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).