Povidone-Iodine
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Also known as BetadineBetadine vc kitBetaseptCodellaE-z prepE-z prep 220E-z scrub 201E-z scrub 241NSC-26245Povidone iodinePvp-iodinePOVIDONE_IODEE
Summary
Povidone-Iodine (CHEMBL1201724) is an approved unknown (ATC D09AA09); indicated across 20 conditions including eye infectious disorder and burn.
At a glance
- Status: Approved (max clinical phase 4)
- Modality: Unknown
- ATC class: D09AA09 (+5 more)
- Indications: 20 conditions
- Clinical trials: 118
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL1201724 |
| Name | Povidone-Iodine |
| Type | Unknown |
| Max phase | 4 |
| ATC | D09AA09, G01AX11, D08AG02, R02AA15, S01AX18, D11AC06 |
Also known as: Betadine, Betadine vc kit, Betasept, Codella, E-z prep, E-z prep 220, E-z scrub 201, E-z scrub 241, NSC-26245, Povidone iodine, Povidone-iodine, Pvp-iodine
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
20 indications (4 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| eye infectious disorder | 4 | MONDO:0043885 | EFO:1001888 |
| burn | 4 | MONDO:0043519 | EFO:0009516 |
| pneumonia | 3 | MONDO:0005249 | EFO:0003106 |
| dental caries | 3 | MONDO:0005276 | EFO:0003819 |
| injury | 3 | MONDO:0021178 | EFO:0000546 |
| viral conjunctivitis | 3 | MONDO:0043541 | EFO:0008571 |
| severe acute respiratory syndrome | 3 | MONDO:0005091 | MONDO:0100096 |
| retinal disorder | 3 | MONDO:0005283 | EFO:0003839 |
| acne | 2 | MONDO:0011438 | EFO:0003894 |
| stomatitis | 2 | MONDO:0004842 | EFO:1001904 |
| Acanthamoeba keratitis | 2 | MONDO:0005629 | EFO:0007126 |
| appendicitis | 2 | MONDO:0005649 | EFO:0007149 |
| empyema | 2 | MONDO:0005242 | EFO:0003097 |
| bacterial infectious disease | 1 | MONDO:0005113 | EFO:0000771 |
| osteoarthritis | 1 | MONDO:0005178 | MONDO:0005178 |
| thymoma | 1 | MONDO:0006456 | EFO:1000581 |
| otomycosis | 1 | MONDO:0000262 | MONDO:0000262 |
| sinusitis | 0 | MONDO:0005961 | EFO:0007486 |
2 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 118.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 52 |
| PHASE4 | 24 |
| PHASE3 | 17 |
| PHASE2 | 12 |
| EARLY_PHASE1 | 5 |
| PHASE1 | 4 |
| PHASE2/PHASE3 | 2 |
| PHASE1/PHASE2 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04210505 | PHASE4 | ACTIVE_NOT_RECRUITING | Nasal Decolonization of Dialysis Patients Noses |
| NCT05763602 | PHASE4 | ACTIVE_NOT_RECRUITING | PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study) |
| NCT06282510 | PHASE4 | RECRUITING | Nasal Antisepsis for C. Auris Prevention |
| NCT07044726 | PHASE4 | RECRUITING | Betadine vs Sterile Water for Periurethral Preparation |
| NCT01175044 | PHASE4 | COMPLETED | Dilute Betadine Lavage in the Prevention of Postoperative Infection |
| NCT01739920 | PHASE4 | COMPLETED | Comparative Efficacy of Different Regimens of PVPI 5% Eye Drops Instillation in Reducing Conjunctival Bacterial Flora |
| NCT02032394 | PHASE4 | UNKNOWN | Effect of Chlorhexidine on Bacteriuria |
| NCT02116608 | PHASE4 | COMPLETED | Treatment of Tracheostomy Granulomas |
| NCT02245334 | PHASE4 | UNKNOWN | A Prospective Trial of Povidone-iodine Suppository Before Transrectal Ultrasound Guided Prostate Biopsy |
| NCT02479347 | PHASE4 | COMPLETED | Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine |
| NCT02527512 | PHASE4 | COMPLETED | Bacterial Contamination: Iodine vs Saline Irrigation in Pediatric Spine Surgery |
| NCT02975921 | PHASE4 | WITHDRAWN | Betadine Pleurodesis Via Tunneled Pleural Catheters |
| NCT03305159 | PHASE4 | COMPLETED | Tolerance of Chlorhexidine Gluconate Vaginal Cleansing Solution |
| NCT03447639 | PHASE4 | TERMINATED | Betadine Bladder Irrigations vs. Standard of Care Prior to Indwelling Catheter Removal |
| NCT04018482 | PHASE4 | COMPLETED | Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study) |
| NCT04146116 | PHASE4 | COMPLETED | Nasal Decolonization for Orthopedic Trauma Patients |
| NCT04745663 | PHASE4 | TERMINATED | Optimizing Preoperative Disinfection of Eyes |
| NCT04941131 | PHASE4 | COMPLETED | The Role of Chlorhexidine in Minimizing the Viral Load Among COVID-19 Patients |
| NCT04981860 | PHASE4 | SUSPENDED | Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine |
| NCT05276687 | PHASE4 | UNKNOWN | Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection |
| NCT05529173 | PHASE4 | COMPLETED | Povidone-Iodine for Nasal Decolonization |
| NCT05745467 | PHASE4 | WITHDRAWN | Povidone Iodine Nasal Application to Prevent Intraoperative Spread of SARS-CoV-2 |
| NCT05919888 | PHASE4 | COMPLETED | SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty |
| NCT05946005 | PHASE4 | COMPLETED | Lidocaine, Povidone Iodine, and Honey Application on Second-degree Perineal Tear Healing |
| NCT05989386 | PHASE2/PHASE3 | RECRUITING | Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies |
| NCT06126614 | PHASE3 | RECRUITING | Infection Prophylaxis in Total Joint Replacement |
| NCT06302335 | PHASE3 | RECRUITING | Povidone-iodine vs Saline Solution in Colorectal Surgeries and Its Effects on the Surgical Site Infection |
| NCT06363877 | PHASE3 | RECRUITING | Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections |
| NCT07383402 | PHASE3 | NOT_YET_RECRUITING | Intra-Sinus Povidone-Iodine and Budesonide After Endoscopic Sinus Surgery for Chronic Rhinosinusitis |
| NCT00231153 | PHASE3 | COMPLETED | Study of Omiganan 1% Gel in Preventing Catheter Infections/Colonization in Patients With Central Venous Catheters |
| NCT00290290 | PHASE3 | COMPLETED | Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections |
| NCT00500669 | PHASE3 | TERMINATED | A Randomised Study to Assess Betadine in the Groin Wound of Patients Undergoing Primary Varicose Vein Surgery |
| NCT00516399 | PHASE3 | TERMINATED | A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine |
| NCT00528008 | PHASE3 | TERMINATED | A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections |
| NCT00692484 | PHASE3 | COMPLETED | Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics |
| NCT00950027 | PHASE3 | TERMINATED | Study of Povidone Iodine to Reduce Pulmonary Infection in Head Trauma and Cerebral Hemorrhage in Intensive Care Unit |
| NCT01495117 | PHASE3 | COMPLETED | Study of Chlorhexidine Gluconate as a Preoperative Antisepsis |
| NCT01700803 | PHASE3 | COMPLETED | Povidone Iodine and Cesarean Section Wound Infections |
| NCT02713074 | PHASE3 | COMPLETED | Povidone-iodine Versus Saline in Vaginal Cleansing Before Office Hysteroscopy |
| NCT02915289 | PHASE3 | COMPLETED | Chlorhexidine Gluconate vs Povidone-Iodine Vaginal Cleansing Solution Prior to Cesarean Delivery |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).