Pyrithione

Summary

Pyrithione (CHEMBL1356238) is an approved small molecule.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• Chemistry: 127.17 Da · C5H5NOS

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1356238
Name	Pyrithione
Type	Small molecule
Max phase	4
FDA approved	yes
PubChem CID	1570
ChEBI	CHEBI:36584
Molecular formula	C5H5NOS
Molecular weight	127.17
InChIKey	YBBJKCMMCRQZMA-UHFFFAOYSA-N

SMILES: C1=CC(=S)N(C=C1)O

IUPAC name: 1-hydroxypyridine-2-thione

Also known as: SID57260394, Pyrithione, PYRITHIONE, PYRITHIONE ZINC, US11491146, Compound 2b

Parent form; salt/anhydrous children: CHEMBL1200471, CHEMBL2364542, CHEMBL5275549

Patent coverage: 6,039 distinct patent families (15,582 SureChEMBL compound mentions), from 2 matched compound structure(s). One matched structure accounts for 15,512 (100%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

Broader ChEMBL bioactivity targets: 10 (assay-derived). Sample: Ras-related protein Rab-9A, FAD-linked sulfhydryl oxidase ALR, Beta-lactamase, Protein-lysine 6-oxidase, Stromelysin-1, Lysyl oxidase homolog 2, Heat shock protein HSP 90-alpha, Lysyl oxidase homolog 3, Lysyl oxidase homolog 4, Replicase polyprotein 1ab.

Bioactivity

ChEMBL activities: 5 potent at pChembl ≥ 5 of 11 total. Top 30 by potency (10 = 0.1 nM, 6 = 1 µM):

Target	pChembl	Type	Value	Unit	Activity ID
P0DTD1	7.3	IC50	50	nM	CHEMBL_ACT_19964221
GFER	6.37	AC50	432	nM	CHEMBL_ACT_5502700
HSP90AA1	6	AC50	1008	nM	CHEMBL_ACT_7457451
P00811	5.3	Potency	5012	nM	CHEMBL_ACT_4662169
RAB9A	5.2	Potency	6310	nM	CHEMBL_ACT_3850876

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

0 indications (0 at ChEMBL trial phase 4).

Clinical trials

Total trials: 0.

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).