Remimazolam
drug drugOn this page
Also known as Cns 7056CNS-7056ONO-2745REMIMAZOLAM (BENZENESULFONATE)
Summary
Remimazolam (CHEMBL4297526) is an approved small molecule (ATC N05CD14); indicated across 6 conditions including atrial fibrillation and parkinson disease.
At a glance
- Status: Approved (max clinical phase 4)
- Modality: Small molecule
- ATC class: N05CD14
- Indications: 6 conditions
- Clinical trials: 140
- Chemistry: 439.3 Da · C21H19BrN4O2
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL4297526 |
| Name | Remimazolam |
| Type | Small molecule |
| Max phase | 4 |
| FDA approved | yes |
| PubChem CID | 9867812 |
| ATC | N05CD14 |
| Molecular formula | C21H19BrN4O2 |
| Molecular weight | 439.3 |
| InChIKey | CYHWMBVXXDIZNZ-KRWDZBQOSA-N |
SMILES: CC1=CN=C2N1C3=C(C=C(C=C3)Br)C(=N[C@H]2CCC(=O)OC)C4=CC=CC=N4
IUPAC name: methyl 3-[(4S)-8-bromo-1-methyl-6-pyridin-2-yl-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate
Also known as: Cns 7056, CNS 7056, CNS-7056, ONO-2745, Remimazolam, REMIMAZOLAM, REMIMAZOLAM (BENZENESULFONATE), Remimazolam (benzenesulfonate)
Parent form; salt/anhydrous children: CHEMBL4297324, CHEMBL4594301
Patent coverage: 106 distinct patent families (273 SureChEMBL compound mentions), from 3 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
4 diseases in clinical trials (phase 1–3, investigational — not approved indications). Highest ChEMBL trial phase per disease; a non-cancer approved use is occasionally logged at phase 3 here.
| Disease (in trials) | Phase | MONDO | EFO |
|---|---|---|---|
| atrial fibrillation | 3 | MONDO:0004981 | EFO:0000275 |
| Parkinson disease | 2 | MONDO:0005180 | MONDO:0005180 |
| drug dependence | 1 | MONDO:0005303 | EFO:0003890 |
| liver disorder | 1 | MONDO:0005154 | EFO:0001421 |
2 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 140.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 65 |
| PHASE4 | 45 |
| PHASE3 | 13 |
| PHASE1 | 7 |
| PHASE2 | 5 |
| EARLY_PHASE1 | 3 |
| PHASE2/PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04532606 | PHASE4 | RECRUITING | Impact of Remimazolam on Prognosis After Bladder Cancer Surgery |
| NCT05728775 | PHASE4 | RECRUITING | REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry |
| NCT05980117 | PHASE4 | RECRUITING | Remimazolam for Cataract Surgery |
| NCT06333145 | PHASE4 | RECRUITING | ED90 of Remimazolam Anesthesia Induction in Drug-induced Sleep Endoscopy in Adults |
| NCT06507202 | PHASE4 | RECRUITING | Comparison of Remimazolam and Propofol for Recovery of Ambulatory Upper Airway Surgery |
| NCT06614036 | PHASE4 | RECRUITING | Remimazolam Versus Midazolam for Sedation During Upper GI Endoscopy: a Randomized Controlled Trial |
| NCT06777758 | PHASE4 | RECRUITING | Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments |
| NCT06784479 | PHASE4 | ACTIVE_NOT_RECRUITING | Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy |
| NCT06816173 | PHASE4 | NOT_YET_RECRUITING | Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression |
| NCT06998732 | PHASE4 | NOT_YET_RECRUITING | BCD to Measure the ED95 of Remimazolam-Assisted Sedation in Arteriovenous Fistula Creation Surgery |
| NCT07046364 | PHASE4 | RECRUITING | Remimazolam and Emergence Delirium in Pediatrics |
| NCT07094945 | PHASE4 | NOT_YET_RECRUITING | The Effect of Remimazolam on Postoperative Sleep Quality |
| NCT07118579 | PHASE4 | RECRUITING | Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy |
| NCT07265128 | PHASE4 | NOT_YET_RECRUITING | Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery |
| NCT07362173 | PHASE4 | ACTIVE_NOT_RECRUITING | Actualities in Procedural Sedation: Remimazolam |
| NCT07611344 | PHASE4 | RECRUITING | The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time |
| NCT04602845 | PHASE4 | COMPLETED | Remimazolam Tosilate Sedation and Midazolam Sedation in Dental Patients |
| NCT04621305 | PHASE4 | UNKNOWN | Remimazolam Reduces Emergence Delirium in Preschool Children Undergoing Laparoscopic Surgery by Sevoflurane Anesthesia |
| NCT04720963 | PHASE4 | COMPLETED | Intranasal Remimazolam for Premedication in Pediatric Patient |
| NCT04815265 | PHASE4 | UNKNOWN | Remimazolam for Sedation in ICU Patients Undergoing Mechanical Ventilation |
| NCT04861337 | PHASE4 | COMPLETED | Remimazolam and Postoperative Nausea and Vomiting in High-risk Patients |
| NCT04919174 | PHASE4 | UNKNOWN | A Randomized Single-blind Clinical Trial of the Efficacy and Safety of Remimazolam in Painless Bronchoscopy |
| NCT04969068 | PHASE4 | UNKNOWN | The Median Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg |
| NCT05340335 | PHASE4 | COMPLETED | ED90 of Remimazolam Loading Dose for Sedation in Patients Under Monitored Anesthetic Care |
| NCT05379777 | PHASE4 | COMPLETED | Effective Dose of Remimazolam for Sedation in Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia |
| NCT05406102 | PHASE4 | UNKNOWN | Remimazolam Improves the Safety in Elderly Patients Undergoing Gastrointestinal Endoscopy |
| NCT05412914 | PHASE4 | UNKNOWN | Remimazolam and Propofol on the Left Ventricular Strain During Anesthesia Induction for Non-cardiac Surgery |
| NCT05429086 | PHASE4 | UNKNOWN | Explore the Advantages of Remimazolam Used on Gastroscopy |
| NCT05436522 | PHASE4 | COMPLETED | REmimazolam vs PrOpofol on Intraoperative hypotenSion in Major Noncardiac surgEry |
| NCT05447507 | PHASE4 | COMPLETED | Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation |
| NCT05468671 | PHASE4 | COMPLETED | Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy |
| NCT05468996 | PHASE4 | COMPLETED | Median Effective Dose of Remimazolam for Sedation in Elderly Patients |
| NCT05480787 | PHASE4 | UNKNOWN | Pharmacokinetic Study of Continuous Infusion of Remazolam in Mechanically Ventilated Patients in ICU |
| NCT05644483 | PHASE4 | COMPLETED | Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position |
| NCT05651399 | PHASE4 | COMPLETED | Comparison in Frequency of Hypotension Between Remimazolam and Propofol in Hip Surgery |
| NCT05688345 | PHASE4 | COMPLETED | Comparison of Recovery Profiles Among Propofol, Remimazolam, and Dexmedetomidine After Intraoperative Sedation |
| NCT05760534 | PHASE4 | COMPLETED | Ideal Dosage for Sedation of Obese Patients Undergoing Knee or Hip Arthroplasty Under Spinal Anesthesia |
| NCT06095570 | PHASE4 | UNKNOWN | The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal Intubation |
| NCT06214117 | PHASE4 | UNKNOWN | Comparison of Emergence Delirium: Remimazolam vs Sevoflurane Anesthesia |
| NCT06513923 | PHASE4 | COMPLETED | Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia |
| NCT06565715 | PHASE4 | COMPLETED | Effect of Remazolam on Hemodynamics During Hepatectomy |
| NCT06664138 | PHASE4 | COMPLETED | Comparison of Remimazolam and Etomidate As Induction Agents for Electroconvulsive Treatment |
| NCT06690424 | PHASE4 | COMPLETED | Clinical Studies of the Efficacy and Safety of Remimazolam for Anesthesia Induction and Maintenance in Elderly Patients |
| NCT06793358 | PHASE4 | WITHDRAWN | Use of Remimazolam and Fentanyl for Procedural Sedation in Patients Undergoing Dental Extraction |
| NCT07076628 | PHASE4 | COMPLETED | Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care |
| NCT04851717 | PHASE2/PHASE3 | ACTIVE_NOT_RECRUITING | Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures |
| NCT07269808 | PHASE3 | ACTIVE_NOT_RECRUITING | Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration |
| NCT07596589 | PHASE3 | RECRUITING | Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU |
| NCT02290873 | PHASE3 | COMPLETED | A Phase III Study of the Efficacy and Safety of Remimazolam Compared to Placebo and Midazolam in Colonoscopy Patients |
| NCT02296892 | PHASE3 | COMPLETED | A Phase III Study of Remimazolam in Patients Undergoing Bronchoscopy |
| NCT02523859 | PHASE3 | TERMINATED | Study of the Efficacy and Safety of Remimazolam in General Anesthesia in Adults Undergoing Cardiac Surgery |
| NCT02532647 | PHASE3 | COMPLETED | Safety and Efficacy of Remimazolam in ASA III and IV Patients Undergoing Colonoscopy |
| NCT03661489 | PHASE3 | COMPLETED | Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery |
| NCT03669484 | PHASE3 | COMPLETED | Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia |
| NCT05220462 | PHASE3 | UNKNOWN | Remimazolam vs Midazolam Cognitive and Motor Recovery After Intravenous Conscious Sedation for Dental Extractions. |
| NCT05836545 | PHASE3 | COMPLETED | Remimazolam Versus Midaszolam for Sedation in Diagnostic Upper Gastrointestinal Endoscopy |
| NCT06013345 | PHASE3 | COMPLETED | COnventional Vs. Optimised PERiprocedural Analgosedation Vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA) |
| NCT06714669 | PHASE3 | COMPLETED | Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy |
| NCT07303985 | PHASE3 | COMPLETED | The Effects of Remimazolam on Cerebral Blood Flow Following General Anesthesia Induction |
| NCT06231563 | PHASE2 | RECRUITING | Ketamine for Veterans With Parkinson’s Disease |
| NCT07086911 | PHASE1/PHASE2 | NOT_YET_RECRUITING | The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy |
| NCT00869440 | PHASE2 | COMPLETED | Dose-Finding Safety Study Evaluating Remimazolam (CNS 7056) in Patients Undergoing Diagnostic Upper GI Endoscopy |
| NCT01937767 | PHASE2 | COMPLETED | Remimazolam Phase II Cardiac Anesthesia Study |
| NCT04611425 | PHASE2 | COMPLETED | REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study |
| NCT05635955 | PHASE2 | COMPLETED | Remimazolam Versus Propofol for Painless Abortion |
| NCT01790607 | PHASE1 | COMPLETED | An Open-label, Single-dose, Intravenous Administration Study of ONO-2745/CNS 7056 in Subjects With Chronic Hepatic Impairment |
| NCT03329014 | PHASE1 | COMPLETED | A Trial of Intranasal Remimazolam Pharmacokinetics, Pharmacodynamics, Safety and Bioavailability |
| NCT04110535 | PHASE1 | COMPLETED | Abuse Potential of Intravenous Remimazolam Compared to Midazolam and Placebo in Recreational CNS Depressant Users |
| NCT04113343 | PHASE1 | COMPLETED | Oral Remimazolam With and Without Alcohol in Healthy Female Subjects |
| NCT04113564 | PHASE1 | COMPLETED | Absolute Oral Bioavailability of Remimazolam |
| NCT04670471 | PHASE1 | COMPLETED | Assessment of the Pharmacodynamic and Pharmacokinetic Interaction of Remimazolam and Remifentanil |
| NCT06129188 | PHASE1 | COMPLETED | Comparison of Procedural Sedation in TEE |
| NCT06756178 | EARLY_PHASE1 | NOT_YET_RECRUITING | Effect of Remimazolam Versus Dexmedetomidine on the Incidence of Delirium After Elective Cardiac Surgery with Cardiopulmonary Bypass: a Prospective Randomized Controlled Trial |
| NCT07012902 | EARLY_PHASE1 | NOT_YET_RECRUITING | Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia |
| NCT07290205 | EARLY_PHASE1 | RECRUITING | Remimazolam NeuroImaging |
| NCT05160987 | Not specified | RECRUITING | Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam |
| NCT05514405 | Not specified | RECRUITING | Effect of Remimazolam and Propofol on Postoperative Delirium |
| NCT05891145 | Not specified | RECRUITING | Remimazolam for Postoperative Atrial Fibrillation |
| NCT06108830 | Not specified | RECRUITING | Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients |
| NCT06115031 | Not specified | RECRUITING | Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients |
| NCT06138340 | Not specified | RECRUITING | The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma |
| NCT06187896 | Not specified | RECRUITING | The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients |
| NCT06258356 | Not specified | NOT_YET_RECRUITING | Remimazolam in High Risk ERCP Patients |
| NCT06432894 | Not specified | RECRUITING | Performance Evaluation of ANI in Patients Under General Anesthesia With Remimazolam |
| NCT06496165 | Not specified | NOT_YET_RECRUITING | Remimazolam Besylate and Propofol Sedation on Hemodynamic for Coronary Artery Bypass Graft Patients |
| NCT06531915 | Not specified | NOT_YET_RECRUITING | Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy |
| NCT06700681 | Not specified | ENROLLING_BY_INVITATION | RCT Comparing Remimazolam With Propofol Under EEG DSA Guidance During Cardiac Electrophysiology Studies and Ablation |
| NCT06716840 | Not specified | RECRUITING | Remimazolam Besylate in Sedation of Postcardioperative Patients |
| NCT06775366 | Not specified | NOT_YET_RECRUITING | The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function |
| NCT06990763 | Not specified | NOT_YET_RECRUITING | Network Pharmacology Was Applied to Explore the Mechanism of Remimazolam Applied in General Anesthesia for Gynecological Surgeries |
| NCT07050212 | Not specified | RECRUITING | Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation |
| NCT07251101 | Not specified | NOT_YET_RECRUITING | Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery |
| NCT07351474 | Not specified | NOT_YET_RECRUITING | Remimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrectomy |
| NCT07459322 | Not specified | NOT_YET_RECRUITING | The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy |
| NCT04950621 | Not specified | COMPLETED | Remimazolam and Endovascular Procedures of Cerebrovascular Diseases |
| NCT04983966 | Not specified | COMPLETED | Comparison of Postoperative QoR-15 Scores Between Desflurane and Remimazolam in Lumbar Fusion Surgery |
| NCT04994704 | Not specified | COMPLETED | Comparison of Postoperative QoR-15 Scores Between Propofol and Remimazolam |
| NCT05025410 | Not specified | COMPLETED | Remimazolam and Remifentanil Without Neuromuscular Blocking Agent |
| NCT05053763 | Not specified | UNKNOWN | The 90% Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg |
| NCT05164146 | Not specified | COMPLETED | The Comparison of Hypotension Incidence Between Remimazolam and Propofol in Hypertensive Patients Undergoing Neurosurgery |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No CPIC/DPWG dosing guideline, but PharmGKB curates 0 clinical and 8 variant annotation(s) for this drug (gene-keyed; see PharmGKB).
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- In clinical trials for: atrial fibrillation, Parkinson disease