Senna
drugOn this page
Also known as Afrikanskaya senna leafAfrikanskaya senna wholeAlexandria sennaAlexandrian senna leafAlexandrian senna wholeB2056Bhuikhakhasa leafBhuikhakhasa wholeBombay senna leafBombay senna wholeCalifigCasse leafCasse wholeCassia acutifolia leafCassia acutifolia wholeCassia alexandrina leafCassia angustifolia leafCassia angustifolia vahlCassia lanceolata leafCassia senna l.
Summary
Senna (CHEMBL2108558) is a phase-3 clinical-stage unknown (ATC A06AB06); indicated across 3 conditions including constipation disorder and gastroparesis.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Unknown
- ATC class: A06AB06 (+1 more)
- Indications: 3 conditions
- Clinical trials: 20
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL2108558 |
| Name | Senna |
| Type | Unknown |
| Max phase | 3 |
| ATC | A06AB06, A06AB56 |
Also known as: Afrikanskaya senna leaf, Afrikanskaya senna whole, Alexandria senna, Alexandrian senna leaf, Alexandrian senna whole, B2056, Bhuikhakhasa leaf, Bhuikhakhasa whole, Bombay senna leaf, Bombay senna whole, Califig, Casse leaf
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
3 indications (2 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| constipation disorder | 4 | MONDO:0002203 | HP:0002019 |
| gastroparesis | 2 | MONDO:0006769 | EFO:1000948 |
1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 20.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 8 |
| PHASE4 | 4 |
| PHASE3 | 4 |
| PHASE2 | 2 |
| PHASE2/PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06825260 | PHASE4 | RECRUITING | PEG3350 vs Senna After Urogyn Surgery |
| NCT01140295 | PHASE4 | TERMINATED | Bowel Preparation for Colonoscopy in Children |
| NCT01773096 | PHASE4 | COMPLETED | Methylnaltrexone Use for Opioid-induced Postoperative Constipation |
| NCT02665624 | PHASE4 | COMPLETED | Adding Stewed Apricot Juice to Senna Improves the Right-Side and Overall Colon Cleansing Quality for Colonoscopy Preparation |
| NCT00275184 | PHASE3 | UNKNOWN | Bowel Preparation and Prokinetics in Capsule Endoscopy |
| NCT00571896 | PHASE2/PHASE3 | COMPLETED | The Use of SennaS for Prevention of Post-operative Constipation After Urogynecologic Surgery |
| NCT00931853 | PHASE3 | COMPLETED | Efficacy and Tolerability of Cassia Fistula Plus Senna Alexandrina Miller (Sugar Free) in the Chronic Functional Constipation (CFC). |
| NCT00990951 | PHASE3 | SUSPENDED | Study of Efficacy of Association of Senna Alexandrina Mill and Associations on Functional Intestinal Constipation |
| NCT00994851 | PHASE3 | COMPLETED | Evaluation of Cassia Fistula + Senna Alexandrina Miller in the Chronic Functional Constipation Treatment. |
| NCT01695850 | PHASE2 | COMPLETED | A Double-blinded,Double-dummy Clinical Trial of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation |
| NCT03342157 | PHASE2 | TERMINATED | Docusate/Senna for the Treatment of Diabetic Gastroparesis |
| NCT07604025 | EARLY_PHASE1 | NOT_YET_RECRUITING | Senna vs. Polyethylene Glycol 3350 for the Treatment of Retentive Encopresis in Children: a Randomized, Double-blinded, Study |
| NCT00662363 | Not specified | COMPLETED | Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation |
| NCT02008864 | Not specified | COMPLETED | Evaluating the Effect of Senna in Uremic Pruritus |
| NCT02239510 | Not specified | TERMINATED | Efficacy of Linaclotide to Senna for CIC |
| NCT02383758 | Not specified | COMPLETED | An Interdisciplinary Approach to the Treatment of Encopresis in Children With Autism Spectrum Disorders |
| NCT02481219 | Not specified | COMPLETED | Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure |
| NCT03501498 | Not specified | COMPLETED | Gut Transit Effect on Enterohepatic Circulation |
| NCT03593252 | Not specified | UNKNOWN | Bowel Preparation in Elective Pediatric Colorectal Surgery |
| NCT04930237 | Not specified | WITHDRAWN | RELISTOR’s Effects on Opioid-Induced Constipation |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: constipation disorder