Sevoflurane

Summary

Sevoflurane (CHEMBL1200694) is an approved small-molecule inhalation anaesthetic (ATC N01AB08); indicated across 36 conditions including severe acute respiratory syndrome and brain aneurysm.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: N01AB08
• Indications: 36 conditions
• Clinical trials: 475
• Chemistry: 200.05 Da · C4H3F7O

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1200694
Name	Sevoflurane
Type	Small molecule
Max phase	4
FDA approved	yes
PubChem CID	5206
ChEBI	CHEBI:9130
ATC	N01AB08
Molecular formula	C4H3F7O
Molecular weight	200.05
InChIKey	DFEYYRMXOJXZRJ-UHFFFAOYSA-N

SMILES: C(OC(C(F)(F)F)C(F)(F)F)F

IUPAC name: 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane

ChEBI definition: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Pharmacological roles (ChEBI): inhalation anaesthetic, platelet aggregation inhibitor, central nervous system depressant.

Also known as: MR-6S4, MR6S4, MR_6S4, NSC-760367, Sevocalm, Sevoflo, Sevoflurane, Sevoflurano, Sevohale (previously known as sevocalm), Sevorane, Sojourn, Ultane

Parent form; salt/anhydrous children: CHEMBL5394621

Patent coverage: 3,433 distinct patent families (9,963 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

36 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
severe acute respiratory syndrome	3	MONDO:0005091	EFO:0000694
brain aneurysm	3	MONDO:0005291	EFO:0003870
acute respiratory distress syndrome	3	MONDO:0006502	EFO:1000637
coronary artery disorder	3	MONDO:0005010	EFO:0001645
ischemia reperfusion injury	3	MONDO:0005203	EFO:0002687
respiratory failure	3	MONDO:0021113	EFO:0009686
neoplasm	3	MONDO:0005070	MONDO:0004992
cerebral arterial disease	3	MONDO:0006693	EFO:1000859
obesity disorder	2	MONDO:0011122	EFO:0001073
acute kidney injury	2	MONDO:0002492	HP:0001919
morbid obesity	2	MONDO:0005139	EFO:0001074
congenital heart disease	2	MONDO:0005453	EFO:0005207
subarachnoid hemorrhage	2	MONDO:0005099	EFO:0000713
opiate dependence	2	MONDO:0005530	EFO:0005611
delirium	2	MONDO:0045057	EFO:0009267
kidney failure	2	MONDO:0001106	EFO:1002048
toxic shock syndrome	2	MONDO:0001881	EFO:0006834
breast neoplasm	2	MONDO:0021100	MONDO:0007254
lung neoplasm	2	MONDO:0021117	MONDO:0021117
alcohol-related disorders	2	MONDO:0021698	MONDO:0021698
brain injury	2	MONDO:0043510	MONDO:0043510
acute myocardial infarction	2	MONDO:0004781	EFO:0008583
drug dependence	2	MONDO:0005303	EFO:0003890
colon adenocarcinoma	2	MONDO:0002271	EFO:1001949
tonsillitis	2	MONDO:0001039	MONDO:0001039
heart disorder	1	MONDO:0005267	EFO:0003777
chronic kidney disease	1	MONDO:0005300	EFO:0003884
colorectal neoplasm	1	MONDO:0005335	MONDO:0005575

8 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 475.

Phase distribution

Phase	Trials
Not specified	249
PHASE4	143
PHASE3	34
PHASE2	21
PHASE1	10
PHASE1/PHASE2	7
EARLY_PHASE1	6
PHASE2/PHASE3	5

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04475705	PHASE4	RECRUITING	Propofol vs Sevo for Paediatric Tumor Surgery
NCT05303805	PHASE4	RECRUITING	Topical Sevoflurane for Treatment of Chronic Leg Ulcers
NCT05331911	PHASE4	RECRUITING	Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Excision of Primary Liver Tumors
NCT05606692	PHASE4	RECRUITING	Influences of Propofol and Sevoflurane Anesthesia in Ovarian Cancer (Anesthetics)
NCT05663242	PHASE4	RECRUITING	The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action
NCT05926336	PHASE4	RECRUITING	The Effects of Using Different Anesthetics on the Prognosis of Primary Tumors and Its Mechanism of Action
NCT05990790	PHASE4	RECRUITING	The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
NCT06024733	PHASE4	ACTIVE_NOT_RECRUITING	Intravenous Anesthesia by Targeted Controlled Infusion Versus Inhalational Anesthesia on the Surgical Stress Response
NCT06036095	PHASE4	RECRUITING	Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study
NCT06773351	PHASE4	NOT_YET_RECRUITING	A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane
NCT06779890	PHASE4	RECRUITING	Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome
NCT00244283	PHASE4	UNKNOWN	A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery
NCT00244517	PHASE4	TERMINATED	DIAFAX I+II-Effects of Inhalative Anesthetics on Left Ventricular Diastolic Function
NCT00477737	PHASE4	COMPLETED	Early Cardioprotective Effect of Sevoflurane
NCT00526695	PHASE4	UNKNOWN	Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
NCT00534586	PHASE4	COMPLETED	Anesthetics and Auditory, Visceral, and Heat Evoked Potentials
NCT00538421	PHASE4	COMPLETED	Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery
NCT00569816	PHASE4	COMPLETED	Continuous Versus Repetitive Sevoflurane Administration for Preconditioning
NCT00575354	PHASE4	COMPLETED	Comparison of Sevoflurane and Isoflurane Anesthesia for Benign Breast Tumor Excision
NCT00665418	PHASE4	TERMINATED	Sevoflurane and Laryngeal Reflex Responses in Pediatric Patients
NCT00706277	PHASE4	COMPLETED	Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function
NCT00793663	PHASE4	COMPLETED	Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia
NCT00821262	PHASE4	COMPLETED	Sevoflurane in Cardiac Surgery
NCT00922844	PHASE4	TERMINATED	The Effect of Sevoflurane Versus Isoflurane on Vasopressor Need
NCT01048658	PHASE4	COMPLETED	Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures
NCT01084200	PHASE4	COMPLETED	Comparison of Sevoflurane, Propofol, and Sevoflurane Plus Propofol for Maintenance of Anaesthesia
NCT01096212	PHASE4	COMPLETED	Efficacy and Safety of Sevofran in Patients Scheduled for Elective Surgery Under General Anesthesia
NCT01096797	PHASE4	COMPLETED	Correlation Between Pain and Emergence Delirium After Adenotonsillectomy in Preschool Children
NCT01184638	PHASE4	UNKNOWN	Long-term Outcome of General Anesthesia on Dysgnosia
NCT01189721	PHASE4	UNKNOWN	Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery
NCT01199237	PHASE4	COMPLETED	Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
NCT01310582	PHASE4	COMPLETED	Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females
NCT01437462	PHASE4	COMPLETED	Sevoflurane, Propofol, Postoperative Pain
NCT01486953	PHASE4	UNKNOWN	Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum
NCT01548859	PHASE4	UNKNOWN	Comparison of the Effects of Sevoflurane and Midazolam Used for the Maintenance of Anaesthesia on the Levels of Postoperative Cardiac Troponin I in Pediatric Cardiac Surgery
NCT01557920	PHASE4	COMPLETED	The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
NCT01601795	PHASE4	COMPLETED	Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit)
NCT01662622	PHASE4	COMPLETED	Minimal Alveolar Concentration of Sevoflurane Inducing Isoelectric Electroencephalogram
NCT01705743	PHASE4	COMPLETED	Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEG
NCT01715584	PHASE4	UNKNOWN	Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

PharmGKB dosing guidelines (1) — CPIC / DPWG genotype-guided dosing for this drug (drug × pharmacogene):

Guideline	Source	Gene(s)	Dosing	Recommendation
Annotation of CPIC Guideline for desflurane, enflurane, halothane, iso	CPIC	CACNA1S;RYR1		yes

PharmGKB also curates 60 clinical and 49 variant annotation(s) for this drug (gene-keyed; see PharmGKB).

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).