Silver Diammine Fluoride
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Also known as Diammine silver fluorideSilver diamine fluoride
Summary
Silver Diammine Fluoride (CHEMBL4297206) is a phase-3 clinical-stage small molecule; indicated across 2 conditions including dental caries and gingivitis.
At a glance
- Status: Max clinical phase 3 (not approved)
- Modality: Small molecule
- Indications: 2 conditions
- Clinical trials: 64
- Chemistry: 160.928 Da · AgFH6N2
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL4297206 |
| Name | Silver Diammine Fluoride |
| Type | Small molecule |
| Max phase | 3 |
| FDA approved | no |
| PubChem CID | 161820 |
| ChEBI | CHEBI:32129 |
| Molecular formula | AgFH6N2 |
| Molecular weight | 160.928 |
| InChIKey | FJKGRAZQBBWYLG-UHFFFAOYSA-M |
SMILES: N.N.[F-].[Ag+]
IUPAC name: silver;azane;fluoride
Also known as: Diammine silver fluoride, Silver diamine fluoride, Silver diammine fluoride, SILVER DIAMMINE FLUORIDE
Patent coverage: 160 distinct patent families (403 SureChEMBL compound mentions), from 2 matched compound structure(s). One matched structure accounts for 332 (82%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
2 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| dental caries | 3 | MONDO:0005276 | EFO:0003819 |
| gingivitis | 2 | MONDO:0002508 | MONDO:0002508 |
Clinical trials
Total trials: 64.
Phase distribution
| Phase | Trials |
|---|---|
| Not specified | 33 |
| PHASE4 | 9 |
| PHASE3 | 7 |
| PHASE2/PHASE3 | 5 |
| PHASE1 | 4 |
| PHASE2 | 3 |
| EARLY_PHASE1 | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06699199 | PHASE4 | RECRUITING | Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient |
| NCT07194629 | PHASE4 | NOT_YET_RECRUITING | Pilot and Feasibility Study of Impact of SDF 38% Application on Oral Health of Elderly With Autonomy Loss |
| NCT03554980 | PHASE4 | UNKNOWN | Application of SDF Verses NaF Varnish in Treatment of Carious Primary Teeth |
| NCT03557996 | PHASE4 | UNKNOWN | Discoloration of Carious Primary Teeth After Application of Silver Diamine Fluoride Versus Sodium Fluoride Varnish |
| NCT03563534 | PHASE4 | UNKNOWN | Treatment of Primary Molars With Deep Caries Using Silver Diamine Fluoride |
| NCT03568474 | PHASE4 | UNKNOWN | Silver Diamine Fluoride After Minimal Caries Removal Technique in Asymptomatic Young Permanent Teeth With Deep Caries |
| NCT03881020 | PHASE4 | COMPLETED | Comparison of Silver Modified and Conventional Atraumatic Restorative Treatment Modalities |
| NCT04196829 | PHASE4 | UNKNOWN | Staining Potential and Caries Arresting Effect of Silver Diamine Fluoride⁄Potassium Iodide and Silver Diamine Fluoride |
| NCT04777968 | PHASE4 | COMPLETED | Evaluation Of Fluoride Uptake By Dentine Following Silver Diamine Fluoride Under Resin Modified Glass Ionomer Restoration In Carious Primary Molars |
| NCT07265830 | PHASE3 | NOT_YET_RECRUITING | Building Adaptive School-based Interventions for Caries |
| NCT02360124 | PHASE2/PHASE3 | COMPLETED | Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults |
| NCT02601833 | PHASE3 | COMPLETED | Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques |
| NCT02742142 | PHASE2/PHASE3 | COMPLETED | Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas |
| NCT03649659 | PHASE3 | TERMINATED | Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Cavitated Caries Lesions |
| NCT04213573 | PHASE2/PHASE3 | SUSPENDED | Efficacy of Silver Diamine Fluoride and Its Parental Perception |
| NCT04236830 | PHASE2/PHASE3 | COMPLETED | Silver Diamine Fluoride/ Potassium Iodide in Indirect Pulp Capping of Young Permanent Molars |
| NCT04794426 | PHASE3 | UNKNOWN | Post-operative Pain and Child Behavior of Hall Technique Versus SDF in the Management of Carious Primary Molars: RCT |
| NCT04889196 | PHASE3 | UNKNOWN | The Efficiency and Gingival Health Status of Hall Versus SDF Techniques in the Management of Carious Primary Molars |
| NCT05084001 | PHASE2/PHASE3 | UNKNOWN | Silver Diamine Fluoride in Preventing Occlusal Caries in Primary Teeth |
| NCT05221749 | PHASE3 | TERMINATED | The Antibacterial Effect of Nanosilver Fluoride on Primary Teeth |
| NCT05791669 | PHASE3 | COMPLETED | Arrest of Interproximal Caries Lesion With 38% Silver Diamine Fluoride Solution |
| NCT03855527 | PHASE2 | COMPLETED | Effectiveness of Silver Diamine Fluoride as Cavity Disinfectant After Atraumatic Restorative Treatment in Primary Teeth |
| NCT04075474 | PHASE2 | UNKNOWN | Preventing Early Childhood Caries With Silver Diamine Fluoride |
| NCT04186663 | PHASE2 | COMPLETED | Pharmacokinetics of Advantage Arrest in Children |
| NCT05941429 | PHASE1 | ACTIVE_NOT_RECRUITING | Comparison of Cariostatic Effect of Nano-Silver Fluoride Versus Silver Diamine Fluoride |
| NCT01664871 | PHASE1 | COMPLETED | Pharmacokinetics of Diammine Silver Fluoride |
| NCT04561934 | PHASE1 | UNKNOWN | Clinical and Radiographic Evaluation of Deep Occlusal Carious Molars Treated With Partial Caries Removal With and Without Using Silver Diamine Fluoride (SDF) Prior to Resin Composite Restoration. |
| NCT06316323 | PHASE1 | COMPLETED | The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish |
| NCT03089567 | EARLY_PHASE1 | WITHDRAWN | Comparison of the Salivary Levels of Streptococcus Mutans in Pediatric Patients With Early Childhood Caries After the Application of Silver Diamine Fluoride or 5% Sodium Fluoride Varnish |
| NCT04255251 | EARLY_PHASE1 | UNKNOWN | Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults |
| NCT05403125 | EARLY_PHASE1 | COMPLETED | SDF Application in Oral Cancer Patients to Prevent Dental Caries |
| NCT06786975 | Not specified | NOT_YET_RECRUITING | Effectiveness and Acceptability of SDF Compared to ART for the Management of Early Childhood Caries |
| NCT07181967 | Not specified | RECRUITING | SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children |
| NCT07382245 | Not specified | NOT_YET_RECRUITING | Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children |
| NCT07431463 | Not specified | ACTIVE_NOT_RECRUITING | Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary Teeth: A Randomized Clinical Trial |
| NCT01063530 | Not specified | UNKNOWN | Effects of DIammine SIlver Fluoride on Tooth Sensitivity |
| NCT01860391 | Not specified | COMPLETED | Silver and Fluoride Salivary Levels After the Application of Silver Fluoride |
| NCT02591147 | Not specified | COMPLETED | Silver Diamine Fluoride Pilot Study (SDF) |
| NCT02771704 | Not specified | COMPLETED | Diamine Silver Fluoride and Potassium Iodide |
| NCT02789202 | Not specified | UNKNOWN | Diammine Silver Fluoride in Arresting Enamel Caries Lesions on Babies’ Occlusal Surfaces |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No PharmGKB pharmacogenomic data curated for this drug.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: dental caries