Silver

Summary

Silver (CHEMBL1230866) is an approved small molecule (ATC D08AL30) targeting AQP1; indicated across 7 conditions including tooth disorder and dental caries.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• ATC class: D08AL30
• Targets: 1 (AQP1)
• Indications: 7 conditions
• Clinical trials: 30
• Chemistry: 107.868 Da · Ag+

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1230866
Name	Silver
Type	Small molecule
Max phase	3
FDA approved	yes
PubChem CID	104755
ChEBI	CHEBI:49468
ATC	D08AL30
Molecular formula	Ag+
Molecular weight	107.868
InChIKey	FOIXSVOLVBLSDH-UHFFFAOYSA-N

SMILES: [Ag+]

IUPAC name: silver(1+)

Also known as: Argentum metallicum, Ci 77820, Colloidal silver, E-174, E174, INS NO.174, INS-174, Nanosilver, Silver, Silver (e 174), Silver colloidal, Silver nanoparticles

Patent coverage: 3,032 distinct patent families (4,329 SureChEMBL compound mentions), from 1 matched compound structure(s). Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.

Targets

Targets

Primary targets (GtoPdb curated mechanism): the Cancer dependency column is the DepMap CRISPR fitness signal (% of screened cell lines dependent on the target).

Gene	Target	Action	pAffinity	Cancer dependency	UniProt
AQP1	AQP1			0.2%	P29972

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

Aggregated over 1 target gene(s): AQP1.

Top Reactome pathways

8 total, by targets touching each:

Pathway	Targets	Genes
Erythrocytes take up carbon dioxide and release oxygen	1	AQP1
Erythrocytes take up oxygen and release carbon dioxide	1	AQP1
O2/CO2 exchange in erythrocytes	1	AQP1
Transport of small molecules	1	AQP1
Vasopressin regulates renal water homeostasis via Aquaporins	1	AQP1
Passive transport by Aquaporins	1	AQP1
Aquaporin-mediated transport	1	AQP1
Developmental Lineage of Pancreatic Ductal Cells	1	AQP1

Dominant GO biological processes

GO term	Targets
renal water homeostasis	1
glomerular filtration	1
renal water transport	1
potassium ion transport	1
water transport	1
cell volume homeostasis	1
hyperosmotic response	1
intracellular water homeostasis	1
fibroblast migration	1
positive regulation of fibroblast migration	1
carbon dioxide transport	1
glycerol transmembrane transport	1
sensory perception of pain	1
cellular homeostasis	1
lateral ventricle development	1

Indications & clinical

Indications

7 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
tooth disorder	3	MONDO:0006999	EFO:1001216
dental caries	3	MONDO:0005276	EFO:0003819
burn	2	MONDO:0043519	EFO:0009516
sinusitis	1	MONDO:0005961	EFO:0007486
hip fracture	0	MONDO:0005327	EFO:0003964

2 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 30.

Phase distribution

Phase	Trials
Not specified	20
PHASE1	4
PHASE4	3
PHASE3	1
PHASE2/PHASE3	1
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01084577	PHASE4	COMPLETED	AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers
NCT02108535	PHASE4	COMPLETED	Comparative Analysis of Cost-effectiveness of Silver Dressing in Burns
NCT03667937	PHASE4	UNKNOWN	Effectiveness of a Hydrophobic Dressing for Microorganisms’ Colonization and Infection Control of Vascular Ulcers
NCT02400957	PHASE3	UNKNOWN	Addition of Silver Nanoparticles to a Orthodontic Primer in Preventing Enamel Demineralization Adjacent Brackets
NCT06348849	PHASE2/PHASE3	COMPLETED	The Desensitising Effect of Nanosilver Fluoride in Molar-Incisor Hypomineralisation
NCT02403479	PHASE1/PHASE2	COMPLETED	The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis
NCT01337830	PHASE1	COMPLETED	Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers
NCT01950546	PHASE1	COMPLETED	Nanosilver Fluoride to Prevent Dental Biofilms Growth
NCT02584153	PHASE1	WITHDRAWN	A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery
NCT03752424	PHASE1	UNKNOWN	Topical Silver Nanoparticles for Microbial Activity
NCT02652169	Not specified	RECRUITING	PRF With Topical Antibiotics or Antiseptics in Chronical Wounds Version 1.4
NCT07008040	Not specified	ENROLLING_BY_INVITATION	Assessing the Effect of the Silver Dressing on Surgical Site Infections in Adult Patients Post Cardiac Surgery: a Single Center Randomized Control Trial
NCT07366645	Not specified	NOT_YET_RECRUITING	Clinical and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride, With or Without Application of LED, in Arresting Incipient Permament Molar Caries
NCT07521267	Not specified	RECRUITING	Nano Coated Orthodontic Miniscrews for en Mass Retraction of the Upper Arch
NCT00593684	Not specified	COMPLETED	The Safety Evaluation of Silver Alginate (Algidex™) Dressing in Very Low Birth Weight (VLBW) Infants
NCT00964093	Not specified	COMPLETED	The Effectiveness of Silver Alginate (Algidex) Patch in the Prevention of Central Line Infections in Very Low Birth Weight Infants
NCT01446107	Not specified	COMPLETED	Effectiveness of Fissure Sealant and Topical Fluoride Application in Preventing Dental Caries
NCT02761525	Not specified	COMPLETED	Topical Application of Silver Nanoparticles and Oral Pathogens in Ill Patients
NCT04144673	Not specified	COMPLETED	A Study Investigating the Safety and Efficacy of Bio-Active Silver Hydrosol™ in Providing Immune Support
NCT04431440	Not specified	COMPLETED	Silver Nanoparticles in Multidrug Resistant Bacteria
NCT04431804	Not specified	COMPLETED	THYME AND CARVACROLL Nanoparticle Effect on Fungi
NCT04608578	Not specified	COMPLETED	Evaluation of a Serious Game Aimed at Improving Mental Health in Youth.
NCT04775238	Not specified	UNKNOWN	Effect of Metallic Nanoparticles on Nosocomial Bacteria
NCT04927806	Not specified	COMPLETED	The Effectiveness of Antimicrobial Breathing System on the Presence of Multidrug-resistant Organisms
NCT04930458	Not specified	UNKNOWN	Remineralization of Dentine Caries Using Two Remineralizing Agents Which Are Nanosilver Fluoride and Casein phosphopeptides_amorphous Calcium Phosphate
NCT04978025	Not specified	UNKNOWN	Colloidal Silver, Treatment of COVID-19
NCT05009576	Not specified	COMPLETED	Comparative Study Using Negative Pressure Dressing With & Without Silver Alginate to Promote Healing in Chronic Wounds.
NCT05148910	Not specified	UNKNOWN	Breast Cancer and Intrauterine Contraception
NCT05255913	Not specified	COMPLETED	Effectiveness of Nano-silver Fluoride and Silver Diamine Fluoride for Arresting Early Childhood Caries
NCT05898724	Not specified	COMPLETED	Assessment of the Rate of Oseointegration Surrounding Nano-coated Orthodontic Titanium Miniscrew

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).