Simethicone

Summary

Simethicone (CHEMBL4297192) is an approved unknown; indicated across 6 conditions including infertility disorder and diarrheal disease.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Unknown
• Indications: 6 conditions
• Clinical trials: 33

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL4297192
Name	Simethicone
Type	Unknown
Max phase	4

Also known as: ANTIFOAM A, ANTIFOAM AF, Simethicone, SIMETHICONE

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

6 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
infertility disorder	3	MONDO:0005047	EFO:0000545
diarrheal disease	3	MONDO:0001673	HP:0002014
dyspepsia	3	MONDO:0002268	EFO:0008533
colorectal neoplasm	3	MONDO:0005335	MONDO:0005575
otitis media	2	MONDO:0005441	EFO:0004992

1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 33.

Phase distribution

Phase	Trials
PHASE4	12
Not specified	8
PHASE3	4
PHASE2	4
PHASE1	3
PHASE2/PHASE3	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06812832	PHASE4	RECRUITING	Simethicone as Part of ERAS in Bariatric Surgery Patients
NCT00615303	PHASE4	COMPLETED	The Effectiveness of Simethicone In Improving Visibility During Colonoscopy
NCT01653171	PHASE4	COMPLETED	Premedication With Simethicone or Simethicone Plus N-acetylcysteine in Improving Visibility During Upper Endoscopy
NCT01711437	PHASE4	UNKNOWN	Different Bowel Preparations for Colonoscopy In Children
NCT02161367	PHASE4	COMPLETED	Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery
NCT02217982	PHASE4	TERMINATED	Pilot Study to Assess Dimethyl Fumarate Related GI Symptom Mitigation
NCT02357303	PHASE4	COMPLETED	Simethicone and N-acetylcysteine in Upper Endoscopy - Prospective Double-blinded Randomized Controlled Trial
NCT02708238	PHASE4	COMPLETED	Efficacy of Matricariae Chamomilla L., Melissa Officinalis L. and Tyndallized Lactobacillus Acidophilus (H122) for Infantile Colics
NCT03119168	PHASE4	COMPLETED	Effect of Simethicone on Screening Colonoscopy
NCT04145856	PHASE4	COMPLETED	Combination of Alverine-simeticone and i3.1 Probiotic in IBS-D and IBS-M in Mexico
NCT04709770	PHASE4	UNKNOWN	Low-volume vs High-volume Polyethylene Glycol Based Bowel Preparation for Colonoscopy in People Receiving Hemodialysis
NCT05570669	PHASE4	COMPLETED	Evaluation of Two Different Regimens of Colon Preparations for Advanced Cleaning.
NCT02555228	PHASE2/PHASE3	COMPLETED	Small Volume Simethicone Before Gastroscopy: Any Benefit?
NCT03009604	PHASE3	UNKNOWN	Does Simethicone Improve Operative Field in Gynecological Operations
NCT03410524	PHASE3	COMPLETED	Evaluation of Oral Simethicone With Low Volume Polyethylene Glycol Bowel Preparation During Colonoscopy
NCT03429621	PHASE3	COMPLETED	Effect of Simethicone on Reducing Bowel Interference During Tubal Resection
NCT04802785	PHASE2/PHASE3	UNKNOWN	The Impact of Air Travel on Passenger Cognitive Functions
NCT05175131	PHASE3	COMPLETED	Efficacy and Safety of Mebeverine + Simethicone in Patients With Functional Bowel Disorders
NCT01312038	PHASE2	COMPLETED	Effect of Simethicone on Eustachian Tube Dysfunction
NCT02846155	PHASE2	UNKNOWN	Gastric Preparation of Magnetic-controlled Capsule Endoscopy
NCT03467334	PHASE2	COMPLETED	Infant Colic Treatment With Probiotics
NCT04487834	PHASE2	COMPLETED	Effects of Vivatlac Baby on Crying Behavior of Colicky Babies
NCT01269671	PHASE1	WITHDRAWN	Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain
NCT04186936	PHASE1	COMPLETED	A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy Volunteers
NCT05109390	PHASE1	COMPLETED	A Study of the Drug Interactions Between Danicopan and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adults
NCT01209806	Not specified	COMPLETED	The Effects of Moviprep With Simethicone on Colonic Bubbles
NCT01790139	Not specified	COMPLETED	Oral Iohexol for Fecal/Fluid Tagging for CT Colonography: A Study to Improve Image Quality by Preventing Colonic Bubbles
NCT02523911	Not specified	WITHDRAWN	Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening
NCT02540239	Not specified	COMPLETED	Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy
NCT03166605	Not specified	UNKNOWN	Ingestion of Simethicone After Capsule Ingestion and Its Impact on Quality of Video Capsule Endoscopy- a Pilot Study
NCT03816774	Not specified	COMPLETED	Effect of Adding Simethicone to Split-dose Polyethylene Glycol for Bowel Preparation in a Screening Colonoscopy Setting
NCT04666324	Not specified	UNKNOWN	Effects of Multilac Baby on Fecal Calprotectin Levels of Colicky Babies
NCT05951712	Not specified	COMPLETED	Pre-medication With N-acetylcysteine and Simethicone to Improve Mucosal Visibility During Gastroduodenoscopy

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).