Sodium Chloride
drugOn this page
Also known as 0.9% nacl0.9% saline0.9% saline solutionAqsia (balanced salt soln)AskinaAskina jetB1655Balanced saltBroncho salineBss (balanced salt soln)FlowfusorFreseniusHypromellose in ringers solnIocare (balanced salt soln)IrriclensIsot salineIsotonic salineIsotonic saline solutionIsotonic sodium chloride solutionLabmist
Summary
Sodium Chloride (CHEMBL1200574) is an approved small-molecule emetic (ATC A12CA01); indicated across 448 conditions including diabetes mellitus and congestive heart failure.
At a glance
- Status: Approved (max clinical phase 4)
- Modality: Small molecule
- ATC class: A12CA01 (+3 more)
- Indications: 448 conditions
- Clinical trials: 4,274
- Chemistry: 58.44 Da · ClNa
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL1200574 |
| Name | Sodium Chloride |
| Type | Small molecule |
| Max phase | 4 |
| FDA approved | yes |
| PubChem CID | 5234 |
| ChEBI | CHEBI:26710 |
| ATC | A12CA01, S01XA03, B05CB01, B05XA03 |
| Molecular formula | ClNa |
| Molecular weight | 58.44 |
| InChIKey | FAPWRFPIFSIZLT-UHFFFAOYSA-M |
SMILES: [Na+].[Cl-]
IUPAC name: sodium chloride
ChEBI definition: An inorganic chloride salt having sodium(1+) as the counterion.
Pharmacological roles (ChEBI): emetic, flame retardant.
Other ChEBI roles (chemical / environmental): NMR chemical shift reference compound.
Also known as: 0.9% nacl, 0.9% saline, 0.9% saline solution, Aqsia (balanced salt soln), Askina, Askina jet, B1655, Balanced salt, Broncho saline, Bss (balanced salt soln), Flowfusor, Fresenius
Parent form; salt/anhydrous children: CHEMBL2103896
Patent coverage: 684,508 distinct patent families (1,652,521 SureChEMBL compound mentions), from 2 matched compound structure(s). One matched structure accounts for 1,652,176 (100%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.
Targets
Targets
No target linkage available.
Bioactivity
No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).
Target pathways
No target-pathway data for this drug (no mapped target genes).
Indications & clinical
Indications
448 indications (11 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| diabetes mellitus | 4 | MONDO:0005015 | EFO:0000400 |
| congestive heart failure | 4 | MONDO:0005009 | EFO:0000373 |
| heart failure | 4 | MONDO:0005252 | EFO:0003144 |
| common cold | 4 | MONDO:0005709 | EFO:0007214 |
| eye disorder | 4 | MONDO:0005328 | EFO:0003966 |
| corneal edema | 4 | MONDO:0006712 | EFO:1000879 |
| pneumococcal infection | 3 | MONDO:0005114 | EFO:0000772 |
| injury | 3 | MONDO:0021178 | EFO:0000546 |
| obesity disorder | 3 | MONDO:0011122 | EFO:0001073 |
| kidney disorder | 3 | MONDO:0005240 | EFO:0003086 |
| acute kidney injury | 3 | MONDO:0002492 | HP:0001919 |
| myocardial infarction | 3 | MONDO:0005068 | EFO:0000612 |
| hypotensive disorder | 3 | MONDO:0005468 | EFO:0005251 |
| bronchiolitis | 3 | MONDO:0002465 | HP:0011950 |
| neoplasm | 3 | MONDO:0005070 | EFO:0000616 |
| bronchiectasis | 3 | MONDO:0004822 | HP:0002110 |
| parathyroid gland disorder | 3 | MONDO:0001223 | EFO:0005754 |
| preeclampsia | 3 | MONDO:0005081 | EFO:0000668 |
| non-small cell lung carcinoma | 3 | MONDO:0005233 | EFO:0003060 |
| acute lung injury | 3 | MONDO:0015796 | EFO:0004610 |
| myasthenia gravis | 3 | MONDO:0009688 | EFO:0004991 |
| graft versus host disease | 3 | MONDO:0013730 | EFO:0004599 |
| uterine corpus leiomyoma | 3 | MONDO:0007886 | EFO:0000731 |
| hepatocellular carcinoma | 3 | MONDO:0007256 | EFO:0000182 |
| chronic obstructive pulmonary disease | 3 | MONDO:0005002 | EFO:0000341 |
| cutaneous melanoma | 3 | MONDO:0005012 | EFO:0000389 |
| infertility disorder | 3 | MONDO:0005047 | EFO:0000545 |
| Sjogren syndrome | 3 | MONDO:0010030 | EFO:0000699 |
| stroke disorder | 3 | MONDO:0005098 | EFO:0000712 |
| malaria | 3 | MONDO:0005136 | EFO:0001068 |
| morbid obesity | 3 | MONDO:0005139 | EFO:0001074 |
| cirrhosis of liver | 3 | MONDO:0005155 | EFO:0001422 |
| heart disorder | 3 | MONDO:0005267 | EFO:0003777 |
| relapsing-remitting multiple sclerosis | 3 | MONDO:0005314 | EFO:0003929 |
| bone fracture | 3 | MONDO:0005315 | EFO:0003931 |
| anemia | 3 | MONDO:0002280 | EFO:0004272 |
| scoliosis | 3 | MONDO:0005392 | EFO:0004273 |
| allergic rhinitis | 3 | MONDO:0011786 | EFO:0005854 |
| Japanese encephalitis | 3 | MONDO:0019209 | EFO:0007332 |
| otitis media with effusion | 3 | MONDO:0005892 | EFO:0007415 |
| placenta accreta | 3 | MONDO:0005916 | EFO:0007440 |
| postpoliomyelitis syndrome | 3 | MONDO:0017416 | EFO:0007454 |
| sinusitis | 3 | MONDO:0005961 | EFO:0007486 |
| dry eye syndrome | 3 | MONDO:0006733 | EFO:1000906 |
| frozen shoulder | 3 | MONDO:0006763 | EFO:1000941 |
| obstructive jaundice | 3 | MONDO:0006874 | EFO:1001068 |
| acute cholecystitis | 3 | MONDO:0043994 | EFO:1001289 |
| disease of the tendon | 3 | MONDO:0100010 | EFO:1001434 |
| epicondylitis | 3 | MONDO:0001875 | EFO:1001896 |
| plantar fasciitis | 3 | MONDO:0004833 | EFO:1001909 |
| cleft palate | 3 | MONDO:0016064 | HP:0000175 |
| constipation disorder | 3 | MONDO:0002203 | HP:0002019 |
| atrial fibrillation | 3 | MONDO:0004981 | EFO:0000275 |
| Crohn disease | 3 | MONDO:0005011 | EFO:0000384 |
| severe acute respiratory syndrome | 3 | MONDO:0005091 | EFO:0000694 |
| melanoma | 3 | MONDO:0005105 | EFO:0000756 |
| bacterial infectious disease | 3 | MONDO:0005113 | EFO:0000771 |
| coronary artery disorder | 3 | MONDO:0005010 | EFO:0001645 |
| abscess | 3 | MONDO:0005227 | EFO:0003030 |
| pneumonia | 3 | MONDO:0005249 | EFO:0003106 |
| lung disorder | 3 | MONDO:0005275 | EFO:0003818 |
| male infertility | 3 | MONDO:0005372 | EFO:0004248 |
| osteoarthritis, knee | 3 | MONDO:0005416 | EFO:0004616 |
| angioedema | 3 | MONDO:0010481 | EFO:0005532 |
| fibromyalgia | 3 | MONDO:0005546 | EFO:0005687 |
| severe cutaneous adverse reaction | 3 | MONDO:0005594 | EFO:0006346 |
| toxic shock syndrome | 3 | MONDO:0001881 | EFO:0006834 |
| polymyalgia rheumatica | 3 | MONDO:0019735 | EFO:0008518 |
| rhinitis | 3 | MONDO:0003014 | EFO:0008521 |
| delirium | 3 | MONDO:0045057 | EFO:0009267 |
| cardiac arrest | 3 | MONDO:0000745 | EFO:0009492 |
| corneal neovascularization | 3 | MONDO:0006713 | EFO:1000880 |
| autosomal dominant polycystic kidney disease | 3 | MONDO:0004691 | EFO:1001496 |
| kidney failure | 3 | MONDO:0001106 | EFO:1002048 |
| influenza | 3 | MONDO:0005812 | EFO:0007328 |
| viral pneumonia | 3 | MONDO:0006012 | EFO:0007541 |
| osteoarthritis, hip | 3 | MONDO:0006629 | EFO:1000786 |
| periarthritis | 3 | MONDO:0006898 | EFO:1001097 |
| Raynaud disease | 3 | MONDO:0008364 | EFO:1001145 |
| scleroderma | 3 | MONDO:0019340 | EFO:1001993 |
| iron deficiency anemia | 3 | MONDO:0001356 | HP:0001891 |
| arthropathy | 3 | MONDO:0006816 | HP:0003040 |
| intervertebral disk degenerative disorder | 3 | MONDO:0011385 | HP:0008419 |
| major depressive disorder | 3 | MONDO:0002009 | MONDO:0002009 |
| breast neoplasm | 3 | MONDO:0021100 | MONDO:0007254 |
| ovarian cancer | 3 | MONDO:0008170 | MONDO:0008170 |
| brain injury | 3 | MONDO:0043510 | MONDO:0043510 |
| leiomyoma | 3 | MONDO:0001572 | MONDO:0001572 |
| depressive disorder | 3 | MONDO:0002050 | MONDO:0002050 |
| bursitis | 3 | MONDO:0002471 | MONDO:0002471 |
| Lyme disease | 3 | MONDO:0019632 | EFO:0008510 |
| acute myocardial infarction | 3 | MONDO:0004781 | EFO:0008583 |
| bone cancer | 3 | MONDO:0002129 | EFO:1000350 |
| myocarditis | 3 | MONDO:0004496 | EFO:0009609 |
| allergic contact dermatitis | 3 | MONDO:0006525 | EFO:1000668 |
| diabetic ketoacidosis | 3 | MONDO:0012819 | EFO:1000897 |
| respiratory syncytial virus infectious disease | 3 | MONDO:0001577 | EFO:1001413 |
| alopecia | 3 | MONDO:0004907 | MONDO:0004907 |
| amyotrophic lateral sclerosis | 3 | MONDO:0004976 | MONDO:0004976 |
| type 1 diabetes mellitus | 3 | MONDO:0005147 | MONDO:0005147 |
| type 2 diabetes mellitus | 3 | MONDO:0005148 | MONDO:0005148 |
| osteoarthritis | 3 | MONDO:0005178 | MONDO:0005178 |
| alcohol abuse | 3 | MONDO:0002046 | MONDO:0007079 |
| cystic fibrosis | 3 | MONDO:0009061 | MONDO:0009061 |
| sickle cell disease | 3 | MONDO:0011382 | MONDO:0011382 |
| ovarian hyperstimulation syndrome | 3 | MONDO:0011972 | MONDO:0011972 |
| bronchopulmonary dysplasia | 3 | MONDO:0019091 | MONDO:0019091 |
| hereditary hemorrhagic telangiectasia | 3 | MONDO:0019180 | MONDO:0019180 |
| hereditary angioedema | 3 | MONDO:0019623 | MONDO:0019623 |
| respiratory system disorder | 3 | MONDO:0005087 | EFO:0000684 |
| small cell lung carcinoma | 3 | MONDO:0008433 | EFO:0000702 |
| desmoid tumor | 3 | MONDO:0007608 | EFO:0009907 |
| ileus | 3 | MONDO:0004567 | MONDO:0004567 |
| breast carcinoma | 3 | MONDO:0004989 | EFO:0000305 |
| epilepsy | 3 | MONDO:0005027 | EFO:0000474 |
| urinary tract infection | 3 | MONDO:0100338 | EFO:0003103 |
| gout | 3 | MONDO:0005393 | EFO:0004274 |
| hemangioma | 3 | MONDO:0006500 | EFO:1000635 |
| acute pancreatitis | 3 | MONDO:0006515 | EFO:1000652 |
| overactive bladder | 3 | MONDO:0006624 | EFO:1000781 |
| perinatal asphyxia | 3 | MONDO:0006663 | EFO:1000824 |
| retinopathy of prematurity | 3 | MONDO:0006952 | EFO:1001158 |
| trigeminal neuralgia | 3 | MONDO:0008599 | EFO:1001219 |
| pulmonary aspergilloma | 3 | MONDO:0000266 | EFO:1001834 |
| mastoiditis | 3 | MONDO:0000748 | HP:0000265 |
| pharyngitis | 3 | MONDO:0002258 | MONDO:0002258 |
| intestinal obstruction | 3 | MONDO:0004565 | MONDO:0004565 |
| migraine disorder | 3 | MONDO:0005277 | MONDO:0005277 |
| brain ischemia | 3 | MONDO:0005299 | MONDO:0005299 |
| nasopharyngeal carcinoma | 3 | MONDO:0015459 | MONDO:0015459 |
| encephalitis | 3 | MONDO:0019956 | MONDO:0019956 |
| cocaine dependence | 2 | MONDO:0005186 | EFO:0002610 |
| brain neoplasm | 2 | MONDO:0021211 | EFO:0003833 |
| HIV infectious disease | 2 | MONDO:0005109 | EFO:0000764 |
| dilated cardiomyopathy | 2 | MONDO:0005021 | EFO:0000407 |
| interstitial lung disease | 2 | MONDO:0015925 | EFO:0004244 |
| acute respiratory distress syndrome | 2 | MONDO:0006502 | EFO:1000637 |
| acute myeloid leukemia | 2 | MONDO:0018874 | EFO:0000222 |
| restless legs syndrome | 2 | MONDO:0005391 | EFO:0004270 |
| cardiovascular disorder | 2 | MONDO:0004995 | EFO:0000319 |
| glioblastoma | 2 | MONDO:0018177 | EFO:0000519 |
| ischemic disease | 2 | MONDO:0005053 | EFO:0000556 |
| polyp | 2 | MONDO:0005079 | EFO:0000662 |
| psoriasis | 2 | MONDO:0005083 | EFO:0000676 |
| rheumatoid arthritis | 2 | MONDO:0008383 | EFO:0000685 |
| subarachnoid hemorrhage | 2 | MONDO:0005099 | EFO:0000713 |
| systemic sclerosis | 2 | MONDO:0005100 | EFO:0000717 |
| ulcerative colitis | 2 | MONDO:0005101 | EFO:0000729 |
| aortic aneurysm | 2 | MONDO:0005160 | EFO:0001666 |
| ischemia reperfusion injury | 2 | MONDO:0005203 | EFO:0002687 |
| autism spectrum disorder | 2 | MONDO:0005258 | EFO:0003756 |
| bacterial vaginosis | 2 | MONDO:0005316 | EFO:0003932 |
| hip fracture | 2 | MONDO:0005327 | EFO:0003964 |
| hypospadias | 2 | MONDO:0005345 | EFO:0004209 |
| Dengue hemorrhagic fever | 2 | MONDO:0005358 | EFO:0004227 |
| palmar fibromatosis | 2 | MONDO:0006345 | EFO:0004229 |
| erectile dysfunction | 2 | MONDO:0005362 | EFO:0004234 |
| obsessive-compulsive disorder | 2 | MONDO:0008114 | EFO:0004242 |
| thoracic aortic aneurysm | 2 | MONDO:0005396 | EFO:0004282 |
| colonic neoplasm | 2 | MONDO:0005401 | EFO:0004288 |
| intracerebral hemorrhage | 2 | MONDO:0013792 | EFO:0005669 |
| neuralgia | 2 | MONDO:0021667 | EFO:0005762 |
| head and neck cancer | 2 | MONDO:0005627 | EFO:0006859 |
| atopic conjunctivitis | 2 | MONDO:0005642 | EFO:0007141 |
| appendicitis | 2 | MONDO:0005649 | EFO:0007149 |
| Ebola hemorrhagic fever | 2 | MONDO:0005737 | EFO:0007243 |
| genital herpes | 2 | MONDO:0005770 | EFO:0007282 |
| hidradenitis suppurativa | 2 | MONDO:0006559 | EFO:1000710 |
| pulmonary edema | 2 | MONDO:0006932 | EFO:1001134 |
| acromegaly | 2 | MONDO:0019933 | EFO:1001485 |
| stomatitis | 2 | MONDO:0004842 | EFO:1001904 |
| Tako-tsubo cardiomyopathy | 2 | MONDO:0019018 | EFO:1002000 |
| hypoglycemia | 2 | MONDO:0004946 | HP:0001943 |
| varicose disease | 2 | MONDO:0008638 | HP:0002619 |
| sciatica | 2 | MONDO:0024333 | HP:0011868 |
| benign prostatic hyperplasia | 2 | MONDO:0010811 | EFO:0000284 |
| age-related macular degeneration | 2 | MONDO:0005150 | EFO:0001365 |
| hepatitis C virus infection | 2 | MONDO:0005231 | EFO:0003047 |
| chronic kidney disease | 2 | MONDO:0005300 | EFO:0003884 |
| acne | 2 | MONDO:0011438 | EFO:0003894 |
| carpal tunnel syndrome | 2 | MONDO:0007275 | EFO:0004143 |
| open-angle glaucoma | 2 | MONDO:0005338 | EFO:0004190 |
| eosinophilic esophagitis | 2 | MONDO:0005361 | EFO:0004232 |
| anxiety | 2 | MONDO:0011918 | EFO:0005230 |
| shigellosis | 2 | MONDO:0019345 | EFO:0005585 |
| neonatal abstinence syndrome | 2 | MONDO:0005566 | EFO:0005799 |
| secondary progressive multiple sclerosis | 2 | MONDO:0000450 | EFO:0008522 |
| urothelial carcinoma | 2 | MONDO:0040679 | EFO:0008528 |
| status asthmaticus | 2 | MONDO:0004766 | EFO:0008590 |
| Clostridium infectious disease | 2 | MONDO:0024388 | EFO:0009130 |
| blood coagulation disease | 2 | MONDO:0001531 | EFO:0009314 |
| burn | 2 | MONDO:0043519 | EFO:0009516 |
| headache disorder | 2 | MONDO:0021146 | EFO:0009550 |
| macular degeneration | 2 | MONDO:0003004 | EFO:0009606 |
| rectal cancer | 2 | MONDO:0006519 | EFO:1000657 |
| rosacea | 2 | MONDO:0006604 | EFO:1000760 |
| neovascular glaucoma | 2 | MONDO:0019783 | EFO:1001060 |
| pulpitis | 2 | MONDO:0006937 | EFO:1001139 |
| multiple organ dysfunction syndrome | 2 | MONDO:0043726 | EFO:1001373 |
| myopia | 2 | MONDO:0001384 | HP:0000545 |
| dementia | 2 | MONDO:0001627 | HP:0000726 |
| myelodysplastic syndrome | 2 | MONDO:0018881 | EFO:0000198 |
| viral infectious disease | 2 | MONDO:0005108 | EFO:0000763 |
| acute liver failure | 2 | MONDO:0019542 | HP:0006554 |
| urethral stricture | 2 | MONDO:0002127 | HP:0012227 |
| West Nile fever | 2 | MONDO:0002282 | MONDO:0002282 |
| periodontal disorder | 2 | MONDO:0002635 | MONDO:0002635 |
| lung neoplasm | 2 | MONDO:0021117 | MONDO:0008903 |
| meningitis | 2 | MONDO:0021108 | MONDO:0021108 |
| chronic hepatitis B virus infection | 2 | MONDO:0005366 | EFO:0004239 |
| hypotrichosis | 2 | MONDO:0003037 | MONDO:0003037 |
| adult acute respiratory distress syndrome | 2 | MONDO:0100130 | MONDO:0100130 |
| post-traumatic stress disorder | 2 | MONDO:0005146 | EFO:0001358 |
| compartment syndrome | 2 | MONDO:0004001 | MONDO:0004001 |
| pulmonary hypertension | 2 | MONDO:0005149 | MONDO:0005149 |
| periodontitis | 2 | MONDO:0005076 | EFO:0000649 |
| sunburn | 2 | MONDO:0005326 | EFO:0003958 |
| spinal cord injury | 2 | MONDO:0043797 | EFO:1001919 |
| ventricular septal defect | 2 | MONDO:0002070 | MONDO:0002070 |
| Alzheimer disease | 2 | MONDO:0004975 | MONDO:0004975 |
| asthma | 2 | MONDO:0004979 | MONDO:0004979 |
| cataract | 2 | MONDO:0005129 | MONDO:0005129 |
| Parkinson disease | 2 | MONDO:0005180 | MONDO:0005180 |
| allergic disease | 2 | MONDO:0005271 | MONDO:0005271 |
| multiple sclerosis | 2 | MONDO:0005301 | MONDO:0005301 |
| erythromelalgia | 2 | MONDO:0016028 | MONDO:0007571 |
| Prader-Willi syndrome | 2 | MONDO:0008300 | MONDO:0008300 |
| primary ciliary dyskinesia | 2 | MONDO:0016575 | MONDO:0016575 |
| frontotemporal dementia | 2 | MONDO:0017276 | MONDO:0017276 |
| tuberculosis | 2 | MONDO:0018076 | MONDO:0018076 |
| familial Mediterranean fever | 2 | MONDO:0018088 | MONDO:0018088 |
| lymphedema | 2 | MONDO:0019297 | MONDO:0019297 |
| hepatitis B virus infection | 2 | MONDO:0005344 | EFO:0004197 |
| swine influenza | 2 | MONDO:0005460 | EFO:0005226 |
| interstitial cystitis | 2 | MONDO:0018301 | EFO:0008507 |
| diabetic neuropathy | 2 | MONDO:0006626 | EFO:1000783 |
| temporal arteritis | 2 | MONDO:0008538 | EFO:1001209 |
| myocardial ischemia | 2 | MONDO:0024644 | EFO:1001375 |
| bipolar disorder | 2 | MONDO:0004985 | MONDO:0004985 |
| glaucoma | 2 | MONDO:0005041 | MONDO:0005041 |
| chronic pancreatitis | 2 | MONDO:0005003 | EFO:0000342 |
| ductal breast carcinoma in situ | 2 | MONDO:0005023 | EFO:0000432 |
| pulmonary emphysema | 2 | MONDO:0004849 | EFO:0000464 |
| lymphoma | 2 | MONDO:0005062 | EFO:0000574 |
| mesothelioma | 2 | MONDO:0005065 | EFO:0000588 |
| spondyloarthropathy | 2 | MONDO:0005095 | EFO:0000706 |
| pulmonary arterial hypertension | 2 | MONDO:0015924 | EFO:0001361 |
| liver disorder | 2 | MONDO:0005154 | EFO:0001421 |
| peripartum cardiomyopathy | 2 | MONDO:0018920 | EFO:0002628 |
| empyema | 2 | MONDO:0005242 | EFO:0003097 |
| peripheral neuropathy | 2 | MONDO:0005244 | EFO:0003100 |
| meningococcal infection | 2 | MONDO:0005373 | EFO:0004249 |
| nephrotic syndrome | 2 | MONDO:0005377 | EFO:0004255 |
| sclerosing cholangitis | 2 | MONDO:0018646 | EFO:0004268 |
| brain infarction | 2 | MONDO:0005394 | EFO:0004277 |
| temporomandibular joint disorder | 2 | MONDO:0005473 | EFO:0005279 |
| acute coronary syndrome | 2 | MONDO:0005542 | EFO:0005672 |
| lupus nephritis | 2 | MONDO:0005556 | EFO:0005761 |
| hepatitis E virus infection | 2 | MONDO:0005788 | EFO:0007303 |
| Plasmodium falciparum malaria | 2 | MONDO:0005920 | EFO:0007444 |
| ST-elevation myocardial infarction | 2 | MONDO:0041656 | EFO:0008585 |
| spondylosis, cervical | 2 | MONDO:0008481 | EFO:0009610 |
| premature ejaculation | 2 | MONDO:0001780 | EFO:0803321 |
| cerebral palsy | 2 | MONDO:0006497 | EFO:1000632 |
| newborn respiratory distress syndrome | 2 | MONDO:0700081 | EFO:1000644 |
| adiposis dolorosa | 2 | MONDO:0007070 | EFO:1000667 |
| burning mouth syndrome | 2 | MONDO:0006687 | EFO:1000850 |
| multiple system atrophy | 2 | MONDO:0007803 | EFO:1001050 |
| shoulder impingement syndrome | 2 | MONDO:0006968 | EFO:1001178 |
| rotator cuff syndrome | 2 | MONDO:0007028 | EFO:1001250 |
| complex regional pain syndrome | 2 | MONDO:0019369 | EFO:1001998 |
| cholecystitis | 2 | MONDO:0002155 | HP:0001082 |
| renal artery obstruction | 2 | MONDO:0006945 | HP:0001920 |
| tonsillitis | 2 | MONDO:0001039 | HP:0011110 |
| cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 | 2 | MONDO:0000914 | MONDO:0000914 |
| gingivitis | 2 | MONDO:0002508 | MONDO:0002508 |
| radiculopathy | 2 | MONDO:0002959 | MONDO:0002959 |
| anorexia nervosa | 2 | MONDO:0005351 | MONDO:0005351 |
| craniosynostosis | 2 | MONDO:0015469 | MONDO:0015469 |
| autoimmune disorder of the nervous system | 2 | MONDO:0002977 | MONDO:0020640 |
| long COVID-19 | 2 | MONDO:0100233 | MONDO:0100233 |
| herpes zoster | 1 | MONDO:0005609 | EFO:0006510 |
| skin disorder | 1 | MONDO:0005093 | EFO:0000701 |
| AIDS | 1 | MONDO:0012268 | EFO:0000765 |
| dental caries | 1 | MONDO:0005276 | EFO:0003819 |
| drug dependence | 1 | MONDO:0005303 | EFO:0003890 |
| dengue disease | 1 | MONDO:0005502 | EFO:0005547 |
| prediabetes syndrome | 1 | MONDO:0006920 | EFO:1001121 |
| aorta coarctation | 1 | MONDO:0007345 | EFO:1001267 |
| streptococcal pneumonia | 1 | MONDO:0005972 | EFO:1001474 |
| streptococcal infection | 1 | MONDO:0021680 | EFO:1001476 |
| Hodgkins lymphoma | 1 | MONDO:0004952 | EFO:0000183 |
| hypertensive disorder | 1 | MONDO:0005044 | EFO:0000537 |
| Down syndrome | 1 | MONDO:0008608 | EFO:0001064 |
| nutritional disorder | 1 | MONDO:0005137 | EFO:0001069 |
| Pseudomonas infection | 1 | MONDO:0005141 | EFO:0001076 |
| nicotine dependence | 1 | MONDO:0008575 | EFO:0003768 |
| intermittent vascular claudication | 1 | MONDO:0005295 | EFO:0003876 |
| ventricular tachycardia | 1 | MONDO:0005477 | EFO:0005306 |
| diphtheria | 1 | MONDO:0005504 | EFO:0005549 |
| neuroma | 1 | MONDO:0002173 | EFO:0009619 |
| respiratory failure | 1 | MONDO:0021113 | EFO:0009686 |
| acute kidney tubular necrosis | 1 | MONDO:0006637 | EFO:1000794 |
| mycosis fungoides | 1 | MONDO:0009691 | EFO:1001051 |
| gastroenteritis | 1 | MONDO:0002269 | EFO:1001463 |
| heavy metal poisoning | 1 | MONDO:0023305 | EFO:1001518 |
| patent ductus arteriosus | 1 | MONDO:0011827 | HP:0001643 |
| hypogonadism | 1 | MONDO:0002146 | MONDO:0002146 |
| papilloma | 1 | MONDO:0002363 | MONDO:0002363 |
| substance-related disorder | 1 | MONDO:0002494 | MONDO:0002491 |
| Zika virus infectious disease | 1 | MONDO:0018661 | MONDO:0018661 |
| persistent fetal circulation syndrome | 1 | MONDO:0022430 | EFO:1001103 |
| Salmonella gastroenteritis | 1 | MONDO:0005950 | EFO:0007475 |
| common wart | 1 | MONDO:0001209 | EFO:0009662 |
| essential hypertension | 1 | MONDO:0001134 | MONDO:0001134 |
| mucopolysaccharidosis type 6 | 1 | MONDO:0009661 | MONDO:0009661 |
| mucopolysaccharidosis type 2 | 1 | MONDO:0010674 | MONDO:0010674 |
| Duchenne muscular dystrophy | 1 | MONDO:0010679 | MONDO:0010679 |
| carcinoma | 1 | MONDO:0004993 | EFO:0000313 |
| primary cutaneous T-cell non-Hodgkin lymphoma | 1 | MONDO:0000607 | EFO:0002913 |
| spinal cord neoplasm | 1 | MONDO:0021234 | EFO:0003828 |
| methamphetamine dependence | 1 | MONDO:0005419 | EFO:0004701 |
| psychotic disorder | 1 | MONDO:0005485 | EFO:0005407 |
| schizoaffective disorder | 1 | MONDO:0005487 | EFO:0005411 |
| non-Hodgkin lymphoma | 1 | MONDO:0018908 | EFO:0005952 |
| thoracic outlet syndrome | 1 | MONDO:0005979 | EFO:0007507 |
| scurvy | 1 | MONDO:0009412 | EFO:1000822 |
| primary ovarian failure | 1 | MONDO:0005387 | HP:0008209 |
| achondroplasia | 1 | MONDO:0007037 | MONDO:0007037 |
| epidermolysis bullosa dystrophica | 1 | MONDO:0006543 | MONDO:0009179 |
| meningioma | 1 | MONDO:0016642 | MONDO:0016642 |
| perceptual disorders | 1 | MONDO:0024417 | MONDO:0024417 |
| peripheral arterial disease | 0 | MONDO:0005386 | EFO:0004265 |
| opiate dependence | 0 | MONDO:0005530 | EFO:0005611 |
| brain edema | 0 | MONDO:0006684 | EFO:1000845 |
| exocrine pancreatic carcinoma | 0 | MONDO:0005192 | EFO:0002618 |
| social phobia | 0 | MONDO:0001247 | EFO:1001917 |
| hyperinsulinism | 0 | MONDO:0002177 | HP:0000842 |
| atopic eczema | 0 | MONDO:0004980 | EFO:0000274 |
| nephrolithiasis | 0 | MONDO:0008171 | EFO:0004253 |
| keratitis | 0 | MONDO:0003085 | EFO:0009449 |
| tooth disorder | 0 | MONDO:0006999 | EFO:1001216 |
| pain agnosia | 0 | MONDO:0000675 | EFO:1001484 |
| rectal prolapse | 0 | MONDO:0004754 | HP:0002035 |
104 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 4,274.
Phase distribution
(phase/status distribution below is over 1,600 sampled trials of the 4,274 total).
| Phase | Trials |
|---|---|
| PHASE4 | 975 |
| PHASE3 | 467 |
| PHASE2/PHASE3 | 158 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02216838 | PHASE4 | ACTIVE_NOT_RECRUITING | Treatment of Facial Flushing With Botulinum Toxin A Injections |
| NCT03024879 | PHASE4 | ENROLLING_BY_INVITATION | The Effect of Motilin on the Frequency and Amount of Food Intake |
| NCT03063892 | PHASE4 | RECRUITING | Effect of Tranexamic Acid (TXA) on Reduction of Postoperative Blood Transfusion |
| NCT03168958 | PHASE4 | RECRUITING | Methadone and Quality of Postoperative Recovery |
| NCT03652753 | PHASE4 | RECRUITING | Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC) |
| NCT03968822 | PHASE4 | ACTIVE_NOT_RECRUITING | Intralipid® 20% for Reversal of Local Anesthetics |
| NCT04180397 | PHASE4 | RECRUITING | Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit. |
| NCT04182997 | PHASE4 | RECRUITING | Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy |
| NCT04220671 | PHASE4 | ENROLLING_BY_INVITATION | Measles Vaccination at Health System Contacts |
| NCT04303325 | PHASE4 | RECRUITING | Effect of Esketamine on Postoperative Depression、Gut Microbiota、Bispectral Index Data of Depression Patients Undergoing Breast Cancer Operation (ESPOD-BI) |
| NCT04454203 | PHASE4 | RECRUITING | Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension |
| NCT04913649 | PHASE4 | RECRUITING | Intravenous Iron to Treat Postoperative Anemia in Older Cardiac Surgery Patients |
| NCT04916197 | PHASE4 | RECRUITING | Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET) |
| NCT04921943 | PHASE4 | RECRUITING | Hypertonic Saline for MAC |
| NCT04938765 | PHASE4 | RECRUITING | Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring |
| NCT04991493 | PHASE4 | RECRUITING | Effect of Tramadol on Postoperative Sore Throat After General Anesthesia |
| NCT05029726 | PHASE4 | RECRUITING | Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery |
| NCT05031026 | PHASE4 | ACTIVE_NOT_RECRUITING | Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation |
| NCT05112081 | PHASE4 | NOT_YET_RECRUITING | Evaluation of Botox Treatment on Chronical Scrotal Pain |
| NCT05157126 | PHASE4 | RECRUITING | Gentamicin Open Tibia Study |
| NCT05267886 | PHASE4 | RECRUITING | CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock |
| NCT05292001 | PHASE4 | RECRUITING | Single-dose Intravenous Iron Therapy for Anemia After Orthopaedic Trauma |
| NCT05391971 | PHASE4 | ACTIVE_NOT_RECRUITING | Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder |
| NCT05440240 | PHASE4 | RECRUITING | Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren’s Contracture |
| NCT05564130 | PHASE4 | ACTIVE_NOT_RECRUITING | Bicarbonate for In-Hospital Cardiac Arrest |
| NCT05603468 | PHASE4 | ACTIVE_NOT_RECRUITING | Effect of PRP vs Corticosteroid in Rotator Cuff Tendinopathy Subtypes in Arthroscopic Repair |
| NCT05675527 | PHASE4 | RECRUITING | PRP for Glenohumeral Osteoarthritis |
| NCT05898087 | PHASE4 | RECRUITING | Subpectoral Bupivacaine for Pain Management in Adolescent Reduction Mammaplasty |
| NCT05927233 | PHASE4 | RECRUITING | Effect of Methylprednisolone on Systemic Inflammatory Response During Pediatric Congenital Open-Heart Surgery |
| NCT05950646 | PHASE4 | RECRUITING | Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality |
| NCT05955326 | PHASE4 | RECRUITING | Study to Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke |
| NCT05979493 | PHASE4 | RECRUITING | QL Block in Laparoscopic Myomectomy |
| NCT05996133 | PHASE4 | RECRUITING | Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery |
| NCT06054750 | PHASE4 | NOT_YET_RECRUITING | Testing Regional anesthesia Techniques For Up And Early Discharge Following Knee arthroplasty - a Feasibility Study |
| NCT06067893 | PHASE4 | ENROLLING_BY_INVITATION | Low Dose Dexmedetomidine as a Postoperative Pain Adjunct |
| NCT06143306 | PHASE4 | RECRUITING | Addition of a Pectoserratus Block to Interscalene Block in Patients Undergoing Total Shoulder Replacement |
| NCT06260878 | PHASE4 | RECRUITING | Short-term Intravenous Fluids for Prevention of Post-ERCP Pancreatitis |
| NCT06271707 | PHASE4 | RECRUITING | Stellate Ganglion Block |
| NCT06284473 | PHASE4 | RECRUITING | Ketamine as a Supplement to Local Anesthesia for Minor Procedures |
| NCT06291363 | PHASE4 | RECRUITING | Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception. |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No CPIC/DPWG dosing guideline or drug-level clinical/variant annotations in PharmGKB for this molecule.
Related molecules
Related molecules
No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).
Related Atlas pages
- Diseases: diabetes mellitus, congestive heart failure, heart failure, common cold, eye disorder, corneal edema, pneumococcal infection, injury, obesity disorder, kidney disorder, acute kidney injury, myocardial infarction, hypotensive disorder, bronchiolitis, neoplasm, bronchiectasis, parathyroid gland disorder, preeclampsia, non-small cell lung carcinoma, acute lung injury, myasthenia gravis, graft versus host disease, uterine corpus leiomyoma, hepatocellular carcinoma, chronic obstructive pulmonary disease, cutaneous melanoma, infertility disorder, Sjogren syndrome, stroke disorder, malaria, morbid obesity, cirrhosis of liver, heart disorder, relapsing-remitting multiple sclerosis, bone fracture, anemia, scoliosis, allergic rhinitis, Japanese encephalitis, otitis media with effusion, placenta accreta, postpoliomyelitis syndrome, sinusitis, dry eye syndrome, frozen shoulder, obstructive jaundice, acute cholecystitis, disease of the tendon, epicondylitis, plantar fasciitis, cleft palate, constipation disorder, atrial fibrillation, Crohn disease, severe acute respiratory syndrome, melanoma, bacterial infectious disease, coronary artery disorder, abscess, pneumonia, lung disorder, male infertility, osteoarthritis, knee, angioedema, fibromyalgia, severe cutaneous adverse reaction, toxic shock syndrome, polymyalgia rheumatica, rhinitis, delirium, cardiac arrest, corneal neovascularization, autosomal dominant polycystic kidney disease, kidney failure, influenza, viral pneumonia, osteoarthritis, hip, Raynaud disease, scleroderma, iron deficiency anemia, arthropathy, intervertebral disk degenerative disorder, major depressive disorder, breast neoplasm, ovarian cancer, brain injury, leiomyoma, depressive disorder, bursitis, Lyme disease, acute myocardial infarction, bone cancer, myocarditis, allergic contact dermatitis, diabetic ketoacidosis, respiratory syncytial virus infectious disease, alopecia, amyotrophic lateral sclerosis, type 1 diabetes mellitus, type 2 diabetes mellitus, osteoarthritis, alcohol abuse, cystic fibrosis, sickle cell disease, ovarian hyperstimulation syndrome, bronchopulmonary dysplasia, hereditary hemorrhagic telangiectasia, hereditary angioedema, respiratory system disorder, small cell lung carcinoma, desmoid tumor, ileus, breast carcinoma, epilepsy, urinary tract infection, gout, hemangioma, acute pancreatitis, overactive bladder, perinatal asphyxia, retinopathy of prematurity, trigeminal neuralgia, pulmonary aspergilloma, mastoiditis, pharyngitis, intestinal obstruction, migraine disorder, brain ischemia, nasopharyngeal carcinoma, encephalitis