Stannous Fluoride

Summary

Stannous Fluoride (CHEMBL1909079) is a phase-3 clinical-stage small molecule (ATC A01AA04); indicated across 4 conditions including gingivitis and dental caries.

At a glance

• Status: Max clinical phase 3 (not approved)
• Modality: Small molecule
• ATC class: A01AA04
• Indications: 4 conditions
• Clinical trials: 25

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL1909079
Name	Stannous Fluoride
Type	Small molecule
Max phase	3
ATC	A01AA04

Also known as: Omnigel, Stannous fluoride, Tin fluoride (snf2), Stannous Fluoride, STANNOUS FLUORIDE

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

4 indications (3 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
gingivitis	4	MONDO:0002508	MONDO:0002508
dental caries	4	MONDO:0005276	EFO:0003819
tooth disorder	3	MONDO:0006999	EFO:1001216

1 further indication record had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 25.

Phase distribution

Phase	Trials
Not specified	13
PHASE3	8
PHASE4	3
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01317446	PHASE4	COMPLETED	Effect of Mouthrinsing on Inflammation of the Gums.
NCT02731833	PHASE4	COMPLETED	Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity
NCT02923895	PHASE4	COMPLETED	To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH)
NCT07215767	PHASE3	RECRUITING	Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice
NCT00762177	PHASE3	COMPLETED	Investigate Oral Bacteria in Adult Population
NCT01592851	PHASE3	COMPLETED	Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity
NCT01592864	PHASE3	COMPLETED	The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity
NCT01827670	PHASE3	COMPLETED	Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity
NCT02832375	PHASE3	COMPLETED	Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity
NCT03072719	PHASE3	COMPLETED	The Efficacy of a Dentifrice in Providing Relief From Immediate and Short Term Relief From Dentinal Hypersensitivity
NCT04123665	PHASE3	COMPLETED	A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride
NCT03943095	PHASE2	COMPLETED	Study to Characterize the Efficacy of a Dual Active Dentifrice for the Relief of Dentin Hypersensitivity
NCT02750943	Not specified	COMPLETED	Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease
NCT02752958	Not specified	COMPLETED	Impact of Long Term Management of Dentine Hypersensitivity (DH) With a Daily Use Anti-sensitivity Toothpaste on the Quality of Life Related to Oral Health
NCT02768194	Not specified	COMPLETED	Dentine Tubule Occlusion Assessment in a Modified in Situ Model
NCT02841839	Not specified	COMPLETED	A Study to Evaluate Sampling Methods for Subgingival Plaque
NCT02861664	Not specified	COMPLETED	Assessment of the Efficacy of an Experimental Occlusion Technology Dentifrice in Dentinal Hypersensitivity
NCT02924350	Not specified	COMPLETED	The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH)
NCT02937636	Not specified	COMPLETED	To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population
NCT03160703	Not specified	COMPLETED	Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices
NCT03296657	Not specified	COMPLETED	Analysis of Stannous Fluoride in GCF and Subgingival Plaque
NCT05326373	Not specified	COMPLETED	Stannous Fluoride and Gingivitis
NCT05483062	Not specified	COMPLETED	Effectiveness of Toothpaste Containing the Active Ingredient of Galla Chinensis Extract on Treating Dentin Hypersensitivity
NCT06045026	Not specified	COMPLETED	A Real-World Evidence Study Evaluating Oral Health Related Quality Of Life With Use Of A Stannous Fluoride Anti-Sensitivity Toothpaste For Dentin Hypersensitivity Management
NCT06197555	Not specified	COMPLETED	Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).