Talc Anhydrous

Summary

Talc Anhydrous (CHEMBL3990276) is an approved small molecule.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Small molecule
• Clinical trials: 10
• Chemistry: 361.25 Da · Mg3O11Si4

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL3990276
Name	Talc Anhydrous
Type	Small molecule
Max phase	4
FDA approved	no
PubChem CID	44134961
Molecular formula	Mg3O11Si4
Molecular weight	361.25
InChIKey	XBPUDTAATCFDRE-UHFFFAOYSA-N

SMILES: O=[Mg].O=[Mg].O=[Mg].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O

IUPAC name: tetrakis(dioxosilane);oxomagnesium

Also known as: TALC, Talc

Parent form; salt/anhydrous children: CHEMBL3989756

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

0 indications (0 at ChEMBL trial phase 4).

Clinical trials

Total trials: 10.

Phase distribution

Phase	Trials
PHASE3	5
Not specified	2
PHASE4	1
PHASE2	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04792970	PHASE4	TERMINATED	Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion
NCT00002622	PHASE3	COMPLETED	Talc in Treating Patients With Malignant Pleural Effusion
NCT00002872	PHASE3	COMPLETED	Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions
NCT00042770	PHASE3	COMPLETED	Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer
NCT00821860	PHASE3	COMPLETED	Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma
NCT02674243	PHASE3	COMPLETED	Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion
NCT00530452	PHASE2	UNKNOWN	Phase II Study of CG100649 for Primary Osteoarthritis in Male Subjects
NCT02825095	EARLY_PHASE1	UNKNOWN	Management of Malignant Pleural Effusion - Indwelling Pleural Catheter or Talc Pleurodesis
NCT02045121	Not specified	UNKNOWN	Multicentre Study Comparing Indwelling Pleural Catheter With Talc Pleurodesis for Malignant Pleural Effusion Management
NCT03973957	Not specified	UNKNOWN	Talc Outpatient Pleurodesis With Indwelling Catheter

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).