Tenecteplase

Summary

Tenecteplase (CHEMBL2108791) is an approved enzyme (ATC B01AD11); indicated across 15 conditions including myocardial infarction and thrombotic disease.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Enzyme
• ATC class: B01AD11
• Indications: 15 conditions
• Clinical trials: 93

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL2108791
Name	Tenecteplase
Type	Enzyme
Max phase	4
ATC	B01AD11

Also known as: Metalyse, Rhtnk-tpa, Tenecteplasa, Tenecteplase, TNK-TPA, TENECTEPLASE

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

15 indications (4 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
myocardial infarction	4	MONDO:0005068	EFO:0000612
thrombotic disease	4	MONDO:0000831	HP:0004419
acute myocardial infarction	4	MONDO:0004781	EFO:0008583
stroke disorder	3	MONDO:0005098	EFO:0000712
pulmonary embolism	3	MONDO:0005279	EFO:0003827
ST-elevation myocardial infarction	3	MONDO:0041656	EFO:0008585
retinal artery occlusion	3	MONDO:0006948	EFO:1001154
nervous system disorder	2	MONDO:0005071	EFO:0000618
cerebral infarction	2	MONDO:0002679	MONDO:0002679
brain ischemia	2	MONDO:0005299	MONDO:0005299
acute respiratory distress syndrome	1	MONDO:0006502	EFO:1000637

4 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 93.

Phase distribution

Phase	Trials
PHASE3	46
PHASE2	18
Not specified	12
PHASE4	9
PHASE2/PHASE3	7
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06010628	PHASE4	RECRUITING	Tenecteplase for Acute Ischemic Stroke Within 4.5 to 6 Hours of Onset (EXIT-BT2)
NCT06498323	PHASE4	RECRUITING	Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT
NCT06769256	PHASE4	RECRUITING	Intracoronary rhTNK-tPA Versus Tirofiban in Patients With STEMI and High Thrombus Burden
NCT07203625	PHASE4	RECRUITING	Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours
NCT00168792	PHASE4	TERMINATED	A Trial Evaluating the Efficacy and Safety of Tenecteplase Together With Unfractionated Heparin Prior to Early Percutaneous Coronary Intervention (PCI) as Compared to Standard Primary PCI in Patients With Acute Myocardial Infarction (ASSENT 4 PCI)
NCT02777580	PHASE4	COMPLETED	STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction
NCT02835534	PHASE4	COMPLETED	The Efficacy and Safety of rhTNK-tPA in Comparison With Alteplase(Rt-PA) as Fibrinolytic Therapy of Acute STEMI
NCT04752631	PHASE4	COMPLETED	MRI-guided thrOmbolysis for Stroke bEyond Time Window by TNK
NCT05752916	PHASE4	COMPLETED	Intravenous Thrombolysis With rhTNK-tPA for Acute Non-large Vessel Occlusion in Extended Time Window
NCT03998319	PHASE3	RECRUITING	A Study of Low-dose Intracoronary Thrombolytic Therapy in STEMI (Heart Attack) Patients.
NCT05105633	PHASE2/PHASE3	RECRUITING	Extending the Time Window for Tenecteplase by Recanalization of Basilar Artery Occlusion in Posterior Circulation Stroke
NCT05199194	PHASE3	RECRUITING	Randomization to Endovascular Treatment Alone or Preceded by Systemic Thrombolysis With Tenecteplase in Ischemic Stroke
NCT05199662	PHASE3	RECRUITING	Randomization to Extend Stroke Intravenous ThromboLysis In Evolving Non-Large Vessel Occlusion With TNK (RESILIENT
NCT06320431	PHASE3	RECRUITING	ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
NCT06352632	PHASE3	RECRUITING	ACT-GLOBAL Adaptive Platform Trial for Stroke
NCT06414499	PHASE3	RECRUITING	Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅳ
NCT06658197	PHASE3	RECRUITING	Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke
NCT06949228	PHASE2/PHASE3	RECRUITING	Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial
NCT06954155	PHASE3	RECRUITING	Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-BEYOND
NCT06987305	PHASE3	RECRUITING	Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window
NCT07047014	PHASE3	RECRUITING	Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Tenecteplase in Medium Vessel Occlusion (MeVO) for Acute Ischemic Stroke
NCT07201688	PHASE3	RECRUITING	Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window.
NCT07357987	PHASE3	RECRUITING	Intra-arterial Tenecteplase for Acute Medium Vessel Occlusion Stroke
NCT07361302	PHASE3	RECRUITING	A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well
NCT07471282	PHASE3	NOT_YET_RECRUITING	Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Thrombectomy
NCT07476898	PHASE3	NOT_YET_RECRUITING	Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window
NCT07540416	PHASE3	NOT_YET_RECRUITING	Tenecteplase for Late-Window Stroke Guided by DWI-FLAIR Mismatch
NCT00121446	PHASE2/PHASE3	COMPLETED	Which Therapy for Acute Heart Attacks? (The WEST Study)
NCT00148460	PHASE3	COMPLETED	Trial to Compare the Efficacy and Safety of a Single Bolus of TNK-tPA (Tenecteplase, Metalyse®) With Accelerated Infusion of Rt-PA (Alteplase, Actilyse®) in Asian Patients With Acute Myocardial Infarction
NCT00157261	PHASE3	TERMINATED	Thrombolysis Using Tenecteplase (Metalyse®) in Cardiac Arrest - The TROICA Trial
NCT00395876	PHASE3	COMPLETED	A Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters
NCT00396032	PHASE3	COMPLETED	A Study of Tenecteplase for Restoration of Function in Dysfunctional Hemodialysis Catheters
NCT00396253	PHASE3	COMPLETED	A Study of Tenecteplase for Restoration of Function in Dysfunctional Hemodialysis (HD) Catheters
NCT00396318	PHASE3	COMPLETED	A Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters
NCT00623623	PHASE3	COMPLETED	STREAM-Strategic Reperfusion (With Tenecteplase and Antithrombotic Treatment) Early After Myocardial Infarction
NCT00680628	PHASE3	TERMINATED	Clot Dissolving Treatment for Blood Clots in the Lungs
NCT01949948	PHASE3	COMPLETED	Study of Tenecteplase Versus Alteplase for Thrombolysis (Clot Dissolving) in Acute Ischemic Stroke
NCT02180204	PHASE2/PHASE3	WITHDRAWN	Tenecteplase Versus Alteplase in Ischemic Stroke Management (TALISMAN)
NCT02182011	PHASE3	COMPLETED	A Study to Investigate the Procoagulant Effect of Tenecteplase (TNK-tPA), Alteplase (Rt-PA) and Streptokinase (SK) Administered to Patients With Acute Myocardial Infarction (AMI)
NCT02301910	PHASE3	COMPLETED	Single Bolus Recombinant Nonimmunogenic Staphylokinase Versus Single Bolus Tenecteplase (Metalyse) in STEMI

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).