Verapamil
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Also known as CP-165331D-365IproveratrilNSC-272306NAVerapamil slow releaseVerapamiloVerapramilSID50104517SID90340771SID104171262SID26751825SID50104518SID50104519SID50104520Verapamil (racemic)SID124881789SID124881790SID124881792SID174316170
Summary
Verapamil (CHEMBL6966) is an approved small molecule (ATC C08DA01) targeting SLC29A4, CYP3A4, and TPCN1; indicated across 17 conditions including cardiovascular disorder and atrial fibrillation.
At a glance
- Status: Approved (max clinical phase 4)
- Modality: Small molecule
- ATC class: C08DA01 (+1 more)
- Targets: 13 (SLC29A4, CYP3A4, TPCN1…)
- Indications: 17 conditions
- Clinical trials: 85
- Chemistry: 454.6 Da · C27H38N2O4
Identifiers
Drug identity and classification
| Field | Value |
|---|---|
| ChEMBL ID | CHEMBL6966 |
| Name | Verapamil |
| Type | Small molecule |
| Max phase | 4 |
| FDA approved | yes |
| PubChem CID | 2520 |
| ChEBI | CHEBI:77733 |
| ATC | C08DA01, C08DA51 |
| Molecular formula | C27H38N2O4 |
| Molecular weight | 454.6 |
| InChIKey | SGTNSNPWRIOYBX-UHFFFAOYSA-N |
SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
IUPAC name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
ChEBI definition: A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Also known as: CP-165331, D-365, Iproveratril, NSC-272306NA, Verapamil, Verapamil slow release, Verapamilo, verapamil, Verapramil, SID50104517, SID90340771, SID104171262
Parent form; salt/anhydrous children: CHEMBL1280, CHEMBL483787, CHEMBL1707604
Patent coverage: 20,741 distinct patent families (75,097 SureChEMBL compound mentions), from 3 matched compound structure(s). One matched structure accounts for 74,881 (100%) of the total. Mentions count patents naming the compound (not distinct inventions), so promiscuous / reference molecules inflate the mention figure — families are the dedup metric.
Targets
Targets
Primary targets (GtoPdb curated mechanism): the Cancer dependency column is the DepMap CRISPR fitness signal (% of screened cell lines dependent on the target).
| Gene | Target | Action | pAffinity | Cancer dependency | UniProt |
|---|---|---|---|---|---|
| SLC29A4 | Plasma membrane monoamine transporter | Inhibition | 4.73 | 0.7% | Q7RTT9 |
| CYP3A4 | CYP3A4 | Inhibition | 6.22 | 0% | P08684 |
| TPCN1 | TPC1 | Inhibition | 4.64 | 0% | Q9ULQ1 |
| TPCN2 | TPC2 | Inhibition | 5 | 0.4% | Q8NHX9 |
| KCNJ6 | Kir3.2 | Antagonist | 3.9 | 0.1% | P48051 |
| CACNA1S | Cav1.1 | Antagonist | 5 | 0.2% | Q13698 |
| CACNA1C | Cav1.2 | Antagonist | 6.5 | 0.1% | Q13936 |
| CACNA1D | Cav1.3 | Antagonist | 3.7 | 0.3% | Q01668 |
| CACNA1F | Cav1.4 | 0% | O60840 | ||
| KCNA7 | Kv1.7 | 4.8 | 0.5% | Q96RP8 | |
| KCNA10 | Kv1.8 | 4.3 | 15.2% | Q16322 | |
| KCNC2 | Kv3.2 | 4.9 | 0.6% | Q96PR1 | |
| NALCN | NALCN | 3.4 | 0% | Q8IZF0 |
Broader ChEMBL bioactivity targets: 52 (assay-derived). Sample: Solute carrier organic anion transporter family member 1B1, Chloroquine resistance transporter, 5-hydroxytryptamine receptor 2B, Alpha-2A adrenergic receptor, Alpha-2C adrenergic receptor, Voltage-dependent L-type calcium channel subunit alpha-1C, Histamine H2 receptor, Sodium channel protein type 5 subunit alpha, D(1A) dopamine receptor, Thromboxane A2 receptor.
Bioactivity
ChEMBL activities: 204 potent at pChembl ≥ 5 of 265 total. Top 30 by potency (10 = 0.1 nM, 6 = 1 µM):
| Target | pChembl | Type | Value | Unit | Activity ID |
|---|---|---|---|---|---|
| P16257 | 9.6 | IC50 | 0.25 | nM | CHEMBL_ACT_25872932 |
| P16257 | 8.85 | IC50 | 1.4 | nM | CHEMBL_ACT_431963 |
| P22002 | 8.85 | Ki | 1.4 | nM | CHEMBL_ACT_520262 |
| ABCB1 | 8.53 | IC50 | 2.97 | nM | CHEMBL_ACT_23197995 |
| P22002 | 8.43 | IC50 | 3.7 | nM | CHEMBL_ACT_431962 |
| P22002 | 8.43 | IC50 | 3.7 | nM | CHEMBL_ACT_520261 |
| ABCB1 | 8.41 | IC50 | 3.87 | nM | CHEMBL_ACT_22973720 |
| ABCB1 | 8.34 | IC50 | 4.59 | nM | CHEMBL_ACT_23197991 |
| ABCB1 | 8.31 | IC50 | 4.9 | nM | CHEMBL_ACT_18937252 |
| ABCB1 | 8.28 | IC50 | 5.29 | nM | CHEMBL_ACT_23198011 |
| ABCB1 | 8.17 | IC50 | 6.7 | nM | CHEMBL_ACT_22973666 |
| ABCB1 | 8.15 | IC50 | 7.05 | nM | CHEMBL_ACT_22441303 |
| ABCB1 | 8.07 | IC50 | 8.6 | nM | CHEMBL_ACT_22973675 |
| ABCB1 | 8.07 | IC50 | 8.51 | nM | CHEMBL_ACT_23198003 |
| ABCB1 | 8.05 | IC50 | 8.9 | nM | CHEMBL_ACT_22973729 |
| KCNH2 | 8 | IC50 | 10 | nM | CHEMBL_ACT_13828642 |
| ABCB1 | 7.99 | IC50 | 10.17 | nM | CHEMBL_ACT_23198007 |
| CYP3A4 | 7.96 | IC50 | 11 | nM | CHEMBL_ACT_24516611 |
| ABCB1 | 7.78 | IC50 | 16.49 | nM | CHEMBL_ACT_23197999 |
| ABCB1 | 7.73 | IC50 | 18.43 | nM | CHEMBL_ACT_19081861 |
| ABCB1 | 7.64 | IC50 | 23.08 | nM | CHEMBL_ACT_23197987 |
| ABCB1 | 7.55 | IC50 | 28.16 | nM | CHEMBL_ACT_18935030 |
| ABCB1 | 7.54 | IC50 | 29 | nM | CHEMBL_ACT_15111042 |
| ABCB1 | 7.46 | IC50 | 35.02 | nM | CHEMBL_ACT_19081858 |
| ABCB1 | 7.43 | IC50 | 36.77 | nM | CHEMBL_ACT_23197983 |
| ABCB1 | 7.42 | IC50 | 38 | nM | CHEMBL_ACT_15613081 |
| ABCB1 | 7.42 | IC50 | 38 | nM | CHEMBL_ACT_24365280 |
| P22002 | 7.41 | IC50 | 39 | nM | CHEMBL_ACT_431964 |
| HTR2B | 7.3 | AC50 | 50.2 | nM | CHEMBL_ACT_25164247 |
| Q02485 | 7.24 | Ki | 58 | nM | CHEMBL_ACT_699401 |
Target pathways
Aggregated over 13 target gene(s): SLC29A4, CYP3A4, TPCN1, TPCN2, KCNJ6, CACNA1S, CACNA1C, CACNA1D, CACNA1F, KCNA7, KCNA10, KCNC2, NALCN.
Top Reactome pathways
42 total, by targets touching each:
| Pathway | Targets | Genes |
|---|---|---|
| Neuronal System | 4 | KCNA10, KCNA7, KCNC2, KCNJ6 |
| Potassium Channels | 4 | KCNA10, KCNA7, KCNC2, KCNJ6 |
| Developmental Biology | 3 | CACNA1C, CACNA1D, CACNA1S |
| Voltage gated Potassium channels | 3 | KCNA10, KCNA7, KCNC2 |
| Metabolism | 3 | CACNA1C, CACNA1D, KCNC2 |
| Integration of energy metabolism | 3 | CACNA1C, CACNA1D, KCNC2 |
| Stimuli-sensing channels | 3 | NALCN, TPCN1, TPCN2 |
| NCAM signaling for neurite out-growth | 3 | CACNA1C, CACNA1D, CACNA1S |
| NCAM1 interactions | 3 | CACNA1C, CACNA1D, CACNA1S |
| Regulation of insulin secretion | 3 | CACNA1C, CACNA1D, KCNC2 |
| Axon guidance | 3 | CACNA1C, CACNA1D, CACNA1S |
| Nervous system development | 3 | CACNA1C, CACNA1D, CACNA1S |
| Transport of small molecules | 2 | NALCN, SLC29A4 |
| Adrenaline,noradrenaline inhibits insulin secretion | 2 | CACNA1C, CACNA1D |
| Neurotransmitter receptors and postsynaptic signal transmission | 1 | KCNJ6 |
| Transmission across Chemical Synapses | 1 | KCNJ6 |
| Activation of G protein gated Potassium channels | 1 | KCNJ6 |
| G protein gated Potassium channels | 1 | KCNJ6 |
| Inwardly rectifying K+ channels | 1 | KCNJ6 |
| Phase I - Functionalization of compounds | 1 | CYP3A4 |
| Xenobiotics | 1 | CYP3A4 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 1 | KCNC2 |
| Muscle contraction | 1 | CACNA1C |
| Transport of vitamins, nucleosides, and related molecules | 1 | SLC29A4 |
| SLC-mediated transmembrane transport | 1 | SLC29A4 |
| Aflatoxin activation and detoxification | 1 | CYP3A4 |
| Cardiac conduction | 1 | CACNA1C |
| Phase 0 - rapid depolarisation | 1 | CACNA1C |
| Phase 2 - plateau phase | 1 | CACNA1C |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | 1 | SLC29A4 |
Dominant GO biological processes
| GO term | Targets |
|---|---|
| monoatomic ion transmembrane transport | 11 |
| monoatomic ion transport | 11 |
| transmembrane transport | 10 |
| calcium ion transmembrane transport | 7 |
| calcium ion transport | 6 |
| potassium ion transport | 4 |
| calcium ion import across plasma membrane | 4 |
| potassium ion transmembrane transport | 4 |
| sodium ion transmembrane transport | 3 |
| muscle contraction | 3 |
| action potential | 3 |
| protein homooligomerization | 3 |
| monoatomic cation transmembrane transport | 2 |
| endocytosis involved in viral entry into host cell | 2 |
| calcium-mediated signaling | 2 |
Indications & clinical
Indications
17 indications (1 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).
| Indication | Trial phase | MONDO | EFO |
|---|---|---|---|
| cardiovascular disorder | 4 | MONDO:0004995 | EFO:0000319 |
| atrial fibrillation | 3 | MONDO:0004981 | EFO:0000275 |
| heart failure | 3 | MONDO:0005252 | EFO:0003144 |
| type 1 diabetes mellitus | 3 | MONDO:0005147 | MONDO:0005147 |
| bipolar disorder | 3 | MONDO:0004985 | MONDO:0004985 |
| severe acute respiratory syndrome | 2 | MONDO:0005091 | MONDO:0100096 |
| osteoarthritis, knee | 1 | MONDO:0005416 | EFO:0004616 |
| Hodgkins lymphoma | 1 | MONDO:0004952 | EFO:0000183 |
| Crohn disease | 1 | MONDO:0005011 | EFO:0000384 |
| drug dependence | 1 | MONDO:0005303 | EFO:0003890 |
| respiratory syncytial virus infectious disease | 1 | MONDO:0001577 | EFO:1001413 |
| type 2 diabetes mellitus | 1 | MONDO:0005148 | MONDO:0005148 |
5 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.
Clinical trials
Total trials: 85.
Phase distribution
| Phase | Trials |
|---|---|
| PHASE1 | 32 |
| PHASE4 | 19 |
| Not specified | 14 |
| PHASE3 | 5 |
| PHASE2 | 5 |
| EARLY_PHASE1 | 4 |
| PHASE2/PHASE3 | 3 |
| PHASE1/PHASE2 | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04406259 | PHASE4 | ACTIVE_NOT_RECRUITING | Atrioventricular Block and Cluster Headache (SEVA) |
| NCT05569382 | PHASE4 | RECRUITING | Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy |
| NCT06799169 | PHASE4 | ACTIVE_NOT_RECRUITING | Management of Acute Tinnitus With Migraine Medications |
| NCT06897969 | PHASE4 | NOT_YET_RECRUITING | Comparison of Intralesional Triamcinolone Versus Verapamil for Keloid Treatment |
| NCT00234858 | PHASE4 | COMPLETED | Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR) |
| NCT00234871 | PHASE4 | COMPLETED | Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM) |
| NCT00235001 | PHASE4 | COMPLETED | Russian Study of the Efficacy and Safety of Tarka in Patients With Hypertension |
| NCT00235014 | PHASE4 | COMPLETED | A Study for Prevention of Kidney Disease in Diabetic Patients (BENEDICT) |
| NCT00348530 | PHASE4 | UNKNOWN | Carvedilol Versus Verapamil in Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy |
| NCT00374465 | PHASE4 | UNKNOWN | Therapy With Verapamil or Carvedilol in Chronic Heart Failure |
| NCT00712894 | PHASE4 | COMPLETED | Effects of Different Vasodilators on Coronary No-reflow During primAry percuTaneous Coronary intErvention in Patients With Acute Myocardial Infarction |
| NCT01295047 | PHASE4 | COMPLETED | Comparison of Medical Therapies in Marfan Syndrome. |
| NCT01655303 | PHASE4 | COMPLETED | Rate Control in Atrial Fibrillation |
| NCT01655316 | PHASE4 | COMPLETED | Oral Verapamil in Acute Paroxysmal Supra Ventricular Tachycardia(PSVT) Recurrence Control |
| NCT01720056 | PHASE4 | TERMINATED | Verapamil vs Steroid to Prevent Keloid Recurrence |
| NCT01996436 | PHASE4 | TERMINATED | The Intra-arterial Vasospasm Trial |
| NCT02454491 | PHASE4 | COMPLETED | Verapamil vs Heparin in Transradial Procedures |
| NCT04404439 | PHASE4 | COMPLETED | Treatment of Tinnitus With Migraine Medications |
| NCT06447688 | PHASE4 | COMPLETED | The Role of Verapamil in Radial Artery Spasm |
| NCT06717685 | PHASE3 | RECRUITING | Efficacy of Adenosine as Compared to Verapamil in Paroxysmal Supraventricular Tachycardia (pSVT) Patients |
| NCT00000556 | PHASE3 | COMPLETED | Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) |
| NCT00313157 | PHASE3 | COMPLETED | RATe Control in Atrial Fibrillation |
| NCT00518947 | PHASE3 | COMPLETED | Pharmacotherapy of Treatment-Resistant Mania |
| NCT00679653 | PHASE3 | COMPLETED | Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives |
| NCT00804895 | PHASE2/PHASE3 | COMPLETED | Cluster Headache Cortivazol Injection (CHCI) |
| NCT02772354 | PHASE2/PHASE3 | UNKNOWN | Radiofrequency Ablation of Symptomatic Frequent Ventricular Premature Complexes in Pediatric Population |
| NCT04351763 | PHASE2/PHASE3 | COMPLETED | Amiodarone or Verapamil in COVID-19 Hospitalized Patients With Symptoms |
| NCT03347786 | PHASE1/PHASE2 | RECRUITING | Verapamil for Neuroprotection in Stroke |
| NCT00706810 | PHASE2 | COMPLETED | Combination of Hydroxyurea and Verapamil for Refractory Meningiomas |
| NCT01471704 | PHASE1/PHASE2 | COMPLETED | Study Investigating the Pharmacokinetic Interaction Between INX-08189 and Verapamil HCL ER in Healthy Volunteers |
| NCT01607073 | PHASE2 | COMPLETED | Verapamil as Therapy for Children and Young Adults With Dravet Syndrome |
| NCT01645709 | PHASE1/PHASE2 | TERMINATED | Safety, Tolerability, and Efficacy of IA Verapamil in the Treatment of Joint Pain in Subjects With Osteoarthritis of the Knee |
| NCT02372253 | PHASE2 | COMPLETED | Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes |
| NCT03449251 | PHASE2 | UNKNOWN | A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin |
| NCT05593757 | PHASE2 | UNKNOWN | Quinidine Versus Verapamil in Short-coupled Idiopathic Ventricular Fibrillation |
| NCT00593463 | PHASE1 | COMPLETED | Drug Discrimination in Methadone-Maintained Humans Study 1 |
| NCT00647673 | PHASE1 | COMPLETED | Fasting Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg |
| NCT00648050 | PHASE1 | COMPLETED | Fasting Study of Verapamil HCl Extended-Release Capsules 300 mg to Verelan® PM Extended-Release Capsules 300 mg |
| NCT00648401 | PHASE1 | COMPLETED | Food Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg |
| NCT00649805 | PHASE1 | COMPLETED | Fasting Applesauce Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg |
Clinical evidence (CIViC)
No CIViC predictive evidence (expected for non-precision-medicine drugs).
Pharmacology
Pharmacogenomics
No CPIC/DPWG dosing guideline, but PharmGKB curates 13 clinical and 38 variant annotation(s) for this drug (gene-keyed; see PharmGKB).
Related molecules
Related molecules
Molecules sharing ≥1 of this drug’s curated primary targets, merged from two biobtree sources and ranked by shared-target count, then clinical phase: ChEMBL clinical-stage candidates (development phase ≥2) and PubChem drug-class bioactivity (approved / known drugs acting on the target). Deduplicated by drug name; the drug’s own salt forms are excluded. Note: for a drug with few primary targets a shared-target match can reflect off-target / promiscuous binding rather than the same therapeutic mechanism — the phase ordering surfaces bona-fide therapeutics first.
656 molecules share ≥1 primary target. Top 60 by shared-target count:
| Molecule | Source | Status | Shared targets |
|---|---|---|---|
| Quinidine | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4, KCNA7, SLC29A4 |
| AMIODARONE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4, KCNA7 |
| AMITRIPTYLINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| CHLORPROMAZINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| CLOZAPINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| DILTIAZEM | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| DONEPEZIL | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| DROPERIDOL | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| DULOXETINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| FLECAINIDE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, KCNA7 |
| HALOPERIDOL | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| MITOXANTRONE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| NIFEDIPINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| NILOTINIB | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| NIMODIPINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| PAROXETINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| PIMOZIDE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| SAQUINAVIR | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| THIORIDAZINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| ASTEMIZOLE | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| BEPRIDIL | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| CISAPRIDE | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| DASATINIB | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| HALOFANTRINE | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| MIBEFRADIL | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| TERFENADINE | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| CILOSTAZOL | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| DIAZEPAM | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| DOFETILIDE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| IBUTILIDE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| IMIPRAMINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| LAMIVUDINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| LORATADINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| MELATONIN | ChEMBL + PubChem | Phase 4 (approved) | CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| METHADONE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| MEXILETINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| Nisoldipine | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| PENTOBARBITAL | ChEMBL + PubChem | Phase 4 (approved) | CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| PHENYTOIN | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| RIBAVIRIN | ChEMBL + PubChem | Phase 4 (approved) | CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| RIMEGEPANT | ChEMBL + PubChem | Phase 4 (approved) | CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| RISPERIDONE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| SOLIFENACIN | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| SUNITINIB | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| VORICONAZOLE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1D, CACNA1F, CACNA1S, CYP3A4 |
| SERTINDOLE | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| SPARFLOXACIN | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| TACRINE | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| TERODILINE | ChEMBL | Phase 4 (approved) | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| AJMALINE | ChEMBL | Phase 3 | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| NITRENDIPINE | ChEMBL | Phase 3 | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| CIFENLINE | ChEMBL | Phase 2 | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| GALLOPAMIL | ChEMBL | Phase 2 | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| Belzutifan | PubChem | Approved | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| Moxifloxacin | PubChem | Approved | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| Paliperidone | PubChem | Approved | CACNA1C, CACNA1D, CACNA1F, CACNA1S |
| AMLODIPINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CYP3A4 |
| Fluoxetine | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CYP3A4, SLC29A4 |
| ISRADIPINE | ChEMBL + PubChem | Phase 4 (approved) | CACNA1C, CACNA1D, CYP3A4 |
| Ceftriaxone | PubChem | Approved | CACNA1D, CACNA1F, CACNA1S |
Related Atlas pages
- Genes: SLC29A4, CYP3A4, TPCN1, TPCN2, KCNJ6, CACNA1S, CACNA1C, CACNA1D, CACNA1F, KCNA7, KCNA10, KCNC2, NALCN
- Diseases: cardiovascular disorder, atrial fibrillation, heart failure, type 1 diabetes mellitus, bipolar disorder
- Drugs: Quinidine, Amiodarone, Amitriptyline, Chlorpromazine, Clozapine, Diltiazem, Donepezil, Droperidol, Duloxetine, Flecainide, Haloperidol, Mitoxantrone, Nifedipine, Nilotinib, Nimodipine, Paroxetine, Pimozide, Saquinavir, Thioridazine, Astemizole, Bepridil, Cisapride, Dasatinib, Halofantrine, Mibefradil, Terfenadine, Cilostazol, Diazepam, Dofetilide, Ibutilide, Imipramine, Lamivudine, Loratadine, Melatonin, Methadone, Mexiletine, Nisoldipine, Pentobarbital, Phenytoin, Ribavirin, Rimegepant, Risperidone, Solifenacin, Sunitinib, Voriconazole, Sertindole, Sparfloxacin, Tacrine, Terodiline, Ajmaline, Nitrendipine, Belzutifan, Moxifloxacin, Paliperidone, Amlodipine, Fluoxetine, Isradipine, Ceftriaxone